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Trabecular bone texture detected by plain radiography is associated with MRI-defined osteophytes in finger joints of women without radiographic osteoarthritis

Wolski, M. ; Podsiadlo, P. ; Stachowiak, G. W. ; Englund, M. LU orcid and Haugen, I. K. (2018) In Osteoarthritis and Cartilage 26(7). p.924-928
Abstract

Objective: To examine associations between trabecular bone (TB) texture and magnetic resonance imaging (MRI)-defined osteophytes in finger joints without radiographic osteoarthritis (OA) using an augmented variance orientation transform (AVOT) method. Design: In a cross-sectional study, associations of the TB texture and osteophytes were examined in 21 women with mean (standard deviation) age of 69.9 (5.3) from the Oslo Hand OA cohort. The AVOT was applied to distal and proximal TB regions selected on hand radiographs of the subjects. The regions were adjacent to 57 finger joints (24 distal and 33 proximal interphalangeal) without radiographic OA (Kellgren–Lawrence [KL] grade 0), without MRI-defined joint space narrowing (JSN), bone... (More)

Objective: To examine associations between trabecular bone (TB) texture and magnetic resonance imaging (MRI)-defined osteophytes in finger joints without radiographic osteoarthritis (OA) using an augmented variance orientation transform (AVOT) method. Design: In a cross-sectional study, associations of the TB texture and osteophytes were examined in 21 women with mean (standard deviation) age of 69.9 (5.3) from the Oslo Hand OA cohort. The AVOT was applied to distal and proximal TB regions selected on hand radiographs of the subjects. The regions were adjacent to 57 finger joints (24 distal and 33 proximal interphalangeal) without radiographic OA (Kellgren–Lawrence [KL] grade 0), without MRI-defined joint space narrowing (JSN), bone marrow lesions (BMLs), attrition, erosion, cysts, sclerosis, malalignment (all MRI grades 0) and without or only with mild synovitis (MRI grade 0 or 1). Bone texture parameters were calculated: mean fractal dimension (FDMEAN), FDs in the horizontal (FDH) and vertical (FDV) directions, and along the roughest part (FDSta). Associations between the parameters categorized into groups using tertiles and osteophytes were evaluated using logistic regression adjusted for age. Results: Lower FDSta and FDV in the distal TB regions were associated with increased odds of MRI-defined osteophytes (P < 0.037 for linear trend). No statistically significant associations were found for the proximal regions. Conclusions: Lower mean roughness and lower roughness in vertical and roughest directions of the proximal TB texture are associated with MRI-defined osteophytes in finger joints without radiographic OA. These findings suggest that TB texture may be a useful marker for detecting early hand OA.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Fractals, Hand radiographs, MRI, Trabecular bone
in
Osteoarthritis and Cartilage
volume
26
issue
7
pages
924 - 928
publisher
Elsevier
external identifiers
  • scopus:85046849334
  • pmid:29684481
ISSN
1063-4584
DOI
10.1016/j.joca.2018.04.007
language
English
LU publication?
yes
id
2398ee27-0998-41c0-8b91-35a8c78d2071
date added to LUP
2018-05-25 14:30:00
date last changed
2021-09-22 03:37:59
@article{2398ee27-0998-41c0-8b91-35a8c78d2071,
  abstract     = {<p>Objective: To examine associations between trabecular bone (TB) texture and magnetic resonance imaging (MRI)-defined osteophytes in finger joints without radiographic osteoarthritis (OA) using an augmented variance orientation transform (AVOT) method. Design: In a cross-sectional study, associations of the TB texture and osteophytes were examined in 21 women with mean (standard deviation) age of 69.9 (5.3) from the Oslo Hand OA cohort. The AVOT was applied to distal and proximal TB regions selected on hand radiographs of the subjects. The regions were adjacent to 57 finger joints (24 distal and 33 proximal interphalangeal) without radiographic OA (Kellgren–Lawrence [KL] grade 0), without MRI-defined joint space narrowing (JSN), bone marrow lesions (BMLs), attrition, erosion, cysts, sclerosis, malalignment (all MRI grades 0) and without or only with mild synovitis (MRI grade 0 or 1). Bone texture parameters were calculated: mean fractal dimension (FD<sub>MEAN</sub>), FDs in the horizontal (FD<sub>H</sub>) and vertical (FD<sub>V</sub>) directions, and along the roughest part (FD<sub>Sta</sub>). Associations between the parameters categorized into groups using tertiles and osteophytes were evaluated using logistic regression adjusted for age. Results: Lower FD<sub>Sta</sub> and FD<sub>V</sub> in the distal TB regions were associated with increased odds of MRI-defined osteophytes (P &lt; 0.037 for linear trend). No statistically significant associations were found for the proximal regions. Conclusions: Lower mean roughness and lower roughness in vertical and roughest directions of the proximal TB texture are associated with MRI-defined osteophytes in finger joints without radiographic OA. These findings suggest that TB texture may be a useful marker for detecting early hand OA.</p>},
  author       = {Wolski, M. and Podsiadlo, P. and Stachowiak, G. W. and Englund, M. and Haugen, I. K.},
  issn         = {1063-4584},
  language     = {eng},
  number       = {7},
  pages        = {924--928},
  publisher    = {Elsevier},
  series       = {Osteoarthritis and Cartilage},
  title        = {Trabecular bone texture detected by plain radiography is associated with MRI-defined osteophytes in finger joints of women without radiographic osteoarthritis},
  url          = {http://dx.doi.org/10.1016/j.joca.2018.04.007},
  doi          = {10.1016/j.joca.2018.04.007},
  volume       = {26},
  year         = {2018},
}