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Transcription Factor Networks in B-Lymphocyte Lineage Commitment

Gustafsson, Johanna Tingvall LU orcid ; Hellerstedt, Kim and Sigvardsson, Mikael LU (2025) 1. p.52-64
Abstract

The process that generates the different types of highly differentiated cells in the immune system from hematopoietic stem cells involves not only the acquisition of lineage-specific features, but also the permanent repression of alternative developmental programs and the preservation of lineage identity. The well-charted developmental trajectory of early B-cell development, in combination with abundant loss and gain of function mouse models, provides detailed insights into the molecular mechanisms of B-lymphocyte commitment. This process entails the interplay of transcription factors such as IKZF1, TCF3, EBF1 and PAX5, creating gene regulatory networks that serve to activate lineage-restricted genes and suppress the expression of genes... (More)

The process that generates the different types of highly differentiated cells in the immune system from hematopoietic stem cells involves not only the acquisition of lineage-specific features, but also the permanent repression of alternative developmental programs and the preservation of lineage identity. The well-charted developmental trajectory of early B-cell development, in combination with abundant loss and gain of function mouse models, provides detailed insights into the molecular mechanisms of B-lymphocyte commitment. This process entails the interplay of transcription factors such as IKZF1, TCF3, EBF1 and PAX5, creating gene regulatory networks that serve to activate lineage-restricted genes and suppress the expression of genes associated with alternative cell fates. The functions of these transcription factors are influenced by the epigenetic landscape, as well as external signals, creating an integrated network that balances and drives cellular differentiation. The same regulatory networks are commonly targeted by mutations in B-lymphoid malignancies, thereby linking development to disease. This chapter describes the developmental trajectory of B-cell development and the key regulators of normal and malignant differentiation and lineage commitment in the bone marrow.

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author
; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Acute lymphoblastic leukemia, B-lymphocyte, Bone marrow, Development, Enhancer elements, Epigenetics, Gene regulatory networks, Lineage commitment, Transcription factors
host publication
Encyclopedia of Immunobiology
volume
1
edition
2nd
pages
52 - 64
publisher
Elsevier
external identifiers
  • scopus:105028827582
ISBN
9780123742797
9780128244654
DOI
10.1016/B978-0-12-824465-4.00174-5
language
English
LU publication?
yes
id
23cc91b4-5a22-4ab1-ac2b-ba1ed3ad8538
date added to LUP
2026-02-26 13:33:32
date last changed
2026-02-26 13:34:14
@inbook{23cc91b4-5a22-4ab1-ac2b-ba1ed3ad8538,
  abstract     = {{<p>The process that generates the different types of highly differentiated cells in the immune system from hematopoietic stem cells involves not only the acquisition of lineage-specific features, but also the permanent repression of alternative developmental programs and the preservation of lineage identity. The well-charted developmental trajectory of early B-cell development, in combination with abundant loss and gain of function mouse models, provides detailed insights into the molecular mechanisms of B-lymphocyte commitment. This process entails the interplay of transcription factors such as IKZF1, TCF3, EBF1 and PAX5, creating gene regulatory networks that serve to activate lineage-restricted genes and suppress the expression of genes associated with alternative cell fates. The functions of these transcription factors are influenced by the epigenetic landscape, as well as external signals, creating an integrated network that balances and drives cellular differentiation. The same regulatory networks are commonly targeted by mutations in B-lymphoid malignancies, thereby linking development to disease. This chapter describes the developmental trajectory of B-cell development and the key regulators of normal and malignant differentiation and lineage commitment in the bone marrow.</p>}},
  author       = {{Gustafsson, Johanna Tingvall and Hellerstedt, Kim and Sigvardsson, Mikael}},
  booktitle    = {{Encyclopedia of Immunobiology}},
  isbn         = {{9780123742797}},
  keywords     = {{Acute lymphoblastic leukemia; B-lymphocyte; Bone marrow; Development; Enhancer elements; Epigenetics; Gene regulatory networks; Lineage commitment; Transcription factors}},
  language     = {{eng}},
  pages        = {{52--64}},
  publisher    = {{Elsevier}},
  title        = {{Transcription Factor Networks in B-Lymphocyte Lineage Commitment}},
  url          = {{http://dx.doi.org/10.1016/B978-0-12-824465-4.00174-5}},
  doi          = {{10.1016/B978-0-12-824465-4.00174-5}},
  volume       = {{1}},
  year         = {{2025}},
}