The association between plasma metabolites and future risk of all-cause mortality
Yan, Yingxiao ; Smith, Einar LU ; Melander, Olle LU
and Ottosson, Filip
LU
(2022)
In Journal of Internal Medicine
292(5).
p.804-815
- Abstract
Background: Metabolite profiles provide snapshots of the overall effect of numerous exposures accumulated over life courses, which may lead to health outcomes in the future. Objective: We hypothesized that the risk of all-cause mortality is linked to alterations in metabolism earlier in life, which are reflected in plasma metabolite profiles. We aimed to identify plasma metabolites associated with future risk of all-cause mortality. Methods: Through metabolomics, 110 metabolites were measured in 3833 individuals from the Malmö Diet and Cancer—Cardiovascular Cohort (MDC-CC). A total of 1574 deaths occurred within an average follow-up time of 22.2 years. Metabolites that were significantly associated with all-cause mortality in MDC-CC... (More)
Background: Metabolite profiles provide snapshots of the overall effect of numerous exposures accumulated over life courses, which may lead to health outcomes in the future. Objective: We hypothesized that the risk of all-cause mortality is linked to alterations in metabolism earlier in life, which are reflected in plasma metabolite profiles. We aimed to identify plasma metabolites associated with future risk of all-cause mortality. Methods: Through metabolomics, 110 metabolites were measured in 3833 individuals from the Malmö Diet and Cancer—Cardiovascular Cohort (MDC-CC). A total of 1574 deaths occurred within an average follow-up time of 22.2 years. Metabolites that were significantly associated with all-cause mortality in MDC-CC were replicated in 1500 individuals from Malmö Preventive Project re-examination (MPP), among whom 715 deaths occurred within an average follow-up time of 11.3 years. Results: Twenty two metabolites were significantly associated with all-cause mortality in MDC-CC, of which 13 were replicated in MPP. Levels of trigonelline, glutamate, dimethylglycine, C18-1-carnitine, C16-1-carnitine, C14-1-carnitine, and 1-methyladenosine were associated with an increased risk, while levels of valine, tryptophan, lysine, leucine, histidine, and 2-aminoisobutyrate were associated with a decreased risk of all-cause mortality. Conclusion: We used metabolomics in two Swedish prospective cohorts and identified replicable associations between 13 metabolites and future risk of all-cause mortality. Novel associations between five metabolites—C18-1-carnitine, C16-1-carnitine, C14-1-carnitine, trigonelline, and 2-aminoisobutyrate—and all-cause mortality were discovered. These findings suggest potential new biomarkers for the prediction of mortality and provide insights for understanding the biochemical pathways that lead to mortality.
(Less)
- author
- Yan, Yingxiao
; Smith, Einar
LU
; Melander, Olle
LU
and Ottosson, Filip
LU
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- all-cause mortality, association, metabolite, metabolomics
- in
- Journal of Internal Medicine
- volume
- 292
- issue
- 5
- pages
- 804 - 815
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:35796403
- scopus:85134731954
- ISSN
- 0954-6820
- DOI
- 10.1111/joim.13540
- language
- English
- LU publication?
- yes
- id
- 23d79d43-b3b1-4244-91b9-e9c8857bb22e
- date added to LUP
- 2022-09-06 13:13:33
- date last changed
- 2024-06-13 18:59:31
@article{23d79d43-b3b1-4244-91b9-e9c8857bb22e,
abstract = {{<p>Background: Metabolite profiles provide snapshots of the overall effect of numerous exposures accumulated over life courses, which may lead to health outcomes in the future. Objective: We hypothesized that the risk of all-cause mortality is linked to alterations in metabolism earlier in life, which are reflected in plasma metabolite profiles. We aimed to identify plasma metabolites associated with future risk of all-cause mortality. Methods: Through metabolomics, 110 metabolites were measured in 3833 individuals from the Malmö Diet and Cancer—Cardiovascular Cohort (MDC-CC). A total of 1574 deaths occurred within an average follow-up time of 22.2 years. Metabolites that were significantly associated with all-cause mortality in MDC-CC were replicated in 1500 individuals from Malmö Preventive Project re-examination (MPP), among whom 715 deaths occurred within an average follow-up time of 11.3 years. Results: Twenty two metabolites were significantly associated with all-cause mortality in MDC-CC, of which 13 were replicated in MPP. Levels of trigonelline, glutamate, dimethylglycine, C18-1-carnitine, C16-1-carnitine, C14-1-carnitine, and 1-methyladenosine were associated with an increased risk, while levels of valine, tryptophan, lysine, leucine, histidine, and 2-aminoisobutyrate were associated with a decreased risk of all-cause mortality. Conclusion: We used metabolomics in two Swedish prospective cohorts and identified replicable associations between 13 metabolites and future risk of all-cause mortality. Novel associations between five metabolites—C18-1-carnitine, C16-1-carnitine, C14-1-carnitine, trigonelline, and 2-aminoisobutyrate—and all-cause mortality were discovered. These findings suggest potential new biomarkers for the prediction of mortality and provide insights for understanding the biochemical pathways that lead to mortality.</p>}},
author = {{Yan, Yingxiao and Smith, Einar and Melander, Olle and Ottosson, Filip}},
issn = {{0954-6820}},
keywords = {{all-cause mortality; association; metabolite; metabolomics}},
language = {{eng}},
number = {{5}},
pages = {{804--815}},
publisher = {{Wiley-Blackwell}},
series = {{Journal of Internal Medicine}},
title = {{The association between plasma metabolites and future risk of all-cause mortality}},
url = {{http://dx.doi.org/10.1111/joim.13540}},
doi = {{10.1111/joim.13540}},
volume = {{292}},
year = {{2022}},
}