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Gastric inflammatory markers and interleukins in patients with functional dyspepsia, with and without Helicobacter pylori infection

Andersen, LP; Holck, S; Janulaityte-Gunther, D; Kupcinskas, L; Kiudelis, G; Jonaitis, D; Janciauskas, D; Holck, P; Bennedsen, M and Permin, H, et al. (2005) In Pathogens and Disease 44(2). p.233-238
Abstract
Helicobacter pylori is the most important cause of gastritis, peptic ulcers and the development of gastric cancer. The chronic active inflammation is dominated by neutrophils, macrophages, lymphocytes and plasma cells. Several interleukins (IL-8, IL-10 and IFN-gamma) are involved in the inflammatory process in the gastric mucosa. The aim of this study was to investigate the gastric inflammation in patients with functional dyspepsia. Fifty-three consecutive patients were included and antral biopsies were obtained for histology, culture and immunohistochemistry. The sections were examined for the interleukins IL-4, IL-6, IL-8, IL-10 and IFN-gamma as well as for the cell markers CD4, CD8, CD14, U19, CD25 and CD30. Only CD4 and CD19 were... (More)
Helicobacter pylori is the most important cause of gastritis, peptic ulcers and the development of gastric cancer. The chronic active inflammation is dominated by neutrophils, macrophages, lymphocytes and plasma cells. Several interleukins (IL-8, IL-10 and IFN-gamma) are involved in the inflammatory process in the gastric mucosa. The aim of this study was to investigate the gastric inflammation in patients with functional dyspepsia. Fifty-three consecutive patients were included and antral biopsies were obtained for histology, culture and immunohistochemistry. The sections were examined for the interleukins IL-4, IL-6, IL-8, IL-10 and IFN-gamma as well as for the cell markers CD4, CD8, CD14, U19, CD25 and CD30. Only CD4 and CD19 were significantly increased in patients with increased gastric inflammation and increased density of H. pylori. However, several of the examined markers (IFN-gamma, IL-8, IL-10 and CD14) showed a non-significant trend to be increased in patients with extensive gastric inflammation and high density of H. pylori. Therefore, an arbitrary index (IM11) for all the 11 immunological markers was made as an average value for each of the four morphological groups. For the four morphologically different groups of patients the values were 0.49, 0.77, 0.86 and 1.25, respectively. Significant increases in the index from none to moderate antral inflammation as well as the density of H. pylori were found (p < 0.001). By using an index of inflammatory markers trends can be summarized and thereby significant which may be of importance when gastric inflammation is investigated in children and patients with functional dyspepsia. (c) 2004 Federation of European Microbiological Societies. (Less)
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published
subject
keywords
cell markers, inflammation, CD4, CD19, INF-gamma, IL-10, CD14, IL-8, Helicobacter pylori, interleukins
in
Pathogens and Disease
volume
44
issue
2
pages
233 - 238
publisher
Wiley-Blackwell
external identifiers
  • wos:000229259700019
  • pmid:15866221
  • scopus:24344453447
ISSN
2049-632X
DOI
10.1016/j.femsim.2004.10.022
language
English
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yes
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8946427b-280e-46ed-b14d-04107bc69858 (old id 240190)
date added to LUP
2007-08-14 08:22:35
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2017-08-06 03:30:21
@article{8946427b-280e-46ed-b14d-04107bc69858,
  abstract     = {Helicobacter pylori is the most important cause of gastritis, peptic ulcers and the development of gastric cancer. The chronic active inflammation is dominated by neutrophils, macrophages, lymphocytes and plasma cells. Several interleukins (IL-8, IL-10 and IFN-gamma) are involved in the inflammatory process in the gastric mucosa. The aim of this study was to investigate the gastric inflammation in patients with functional dyspepsia. Fifty-three consecutive patients were included and antral biopsies were obtained for histology, culture and immunohistochemistry. The sections were examined for the interleukins IL-4, IL-6, IL-8, IL-10 and IFN-gamma as well as for the cell markers CD4, CD8, CD14, U19, CD25 and CD30. Only CD4 and CD19 were significantly increased in patients with increased gastric inflammation and increased density of H. pylori. However, several of the examined markers (IFN-gamma, IL-8, IL-10 and CD14) showed a non-significant trend to be increased in patients with extensive gastric inflammation and high density of H. pylori. Therefore, an arbitrary index (IM11) for all the 11 immunological markers was made as an average value for each of the four morphological groups. For the four morphologically different groups of patients the values were 0.49, 0.77, 0.86 and 1.25, respectively. Significant increases in the index from none to moderate antral inflammation as well as the density of H. pylori were found (p &lt; 0.001). By using an index of inflammatory markers trends can be summarized and thereby significant which may be of importance when gastric inflammation is investigated in children and patients with functional dyspepsia. (c) 2004 Federation of European Microbiological Societies.},
  author       = {Andersen, LP and Holck, S and Janulaityte-Gunther, D and Kupcinskas, L and Kiudelis, G and Jonaitis, D and Janciauskas, D and Holck, P and Bennedsen, M and Permin, H and Norn, S and Wadström, Torkel},
  issn         = {2049-632X},
  keyword      = {cell markers,inflammation,CD4,CD19,INF-gamma,IL-10,CD14,IL-8,Helicobacter pylori,interleukins},
  language     = {eng},
  number       = {2},
  pages        = {233--238},
  publisher    = {Wiley-Blackwell},
  series       = {Pathogens and Disease},
  title        = {Gastric inflammatory markers and interleukins in patients with functional dyspepsia, with and without Helicobacter pylori infection},
  url          = {http://dx.doi.org/10.1016/j.femsim.2004.10.022},
  volume       = {44},
  year         = {2005},
}