Tuberculosis and HIV Co-Infection
(2012) In PLoS Pathogens 8(2).- Abstract
- Tuberculosis (TB) and HIV co-infections place an immense burden on health care systems and pose particular diagnostic and therapeutic challenges. Infection with HIV is the most powerful known risk factor predisposing for Mycobacterium tuberculosis infection and progression to active disease, which increases the risk of latent TB reactivation 20-fold. TB is also the most common cause of AIDS-related death. Thus, M. tuberculosis and HIV act in synergy, accelerating the decline of immunological functions and leading to subsequent death if untreated. The mechanisms behind the breakdown of the immune defense of the co-infected individual are not well known. The aim of this review is to highlight immunological events that may accelerate the... (More)
- Tuberculosis (TB) and HIV co-infections place an immense burden on health care systems and pose particular diagnostic and therapeutic challenges. Infection with HIV is the most powerful known risk factor predisposing for Mycobacterium tuberculosis infection and progression to active disease, which increases the risk of latent TB reactivation 20-fold. TB is also the most common cause of AIDS-related death. Thus, M. tuberculosis and HIV act in synergy, accelerating the decline of immunological functions and leading to subsequent death if untreated. The mechanisms behind the breakdown of the immune defense of the co-infected individual are not well known. The aim of this review is to highlight immunological events that may accelerate the development of one of the two diseases in the presence of the co-infecting organism. We also review possible animal models for studies of the interaction of the two pathogens, and describe gaps in knowledge and needs for future studies to develop preventive measures against the two diseases. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2403114
- author
- Pawlowski, Andrzej ; Jansson, Marianne LU ; Skold, Markus ; Rottenberg, Martin E. and Kallenius, Gunilla
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS Pathogens
- volume
- 8
- issue
- 2
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- wos:000300728100004
- scopus:84860908291
- ISSN
- 1553-7366
- DOI
- 10.1371/journal.ppat.1002464
- language
- English
- LU publication?
- yes
- id
- bcd3b862-441f-46d9-b27b-1bf5db5efc50 (old id 2403114)
- date added to LUP
- 2016-04-01 09:55:32
- date last changed
- 2024-02-20 23:37:03
@article{bcd3b862-441f-46d9-b27b-1bf5db5efc50,
abstract = {{Tuberculosis (TB) and HIV co-infections place an immense burden on health care systems and pose particular diagnostic and therapeutic challenges. Infection with HIV is the most powerful known risk factor predisposing for Mycobacterium tuberculosis infection and progression to active disease, which increases the risk of latent TB reactivation 20-fold. TB is also the most common cause of AIDS-related death. Thus, M. tuberculosis and HIV act in synergy, accelerating the decline of immunological functions and leading to subsequent death if untreated. The mechanisms behind the breakdown of the immune defense of the co-infected individual are not well known. The aim of this review is to highlight immunological events that may accelerate the development of one of the two diseases in the presence of the co-infecting organism. We also review possible animal models for studies of the interaction of the two pathogens, and describe gaps in knowledge and needs for future studies to develop preventive measures against the two diseases.}},
author = {{Pawlowski, Andrzej and Jansson, Marianne and Skold, Markus and Rottenberg, Martin E. and Kallenius, Gunilla}},
issn = {{1553-7366}},
language = {{eng}},
number = {{2}},
publisher = {{Public Library of Science (PLoS)}},
series = {{PLoS Pathogens}},
title = {{Tuberculosis and HIV Co-Infection}},
url = {{https://lup.lub.lu.se/search/files/1391020/2858395.pdf}},
doi = {{10.1371/journal.ppat.1002464}},
volume = {{8}},
year = {{2012}},
}