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Tuberculosis and HIV Co-Infection

Pawlowski, Andrzej; Jansson, Marianne LU ; Skold, Markus; Rottenberg, Martin E. and Kallenius, Gunilla (2012) In PLoS Pathogens 8(2).
Abstract
Tuberculosis (TB) and HIV co-infections place an immense burden on health care systems and pose particular diagnostic and therapeutic challenges. Infection with HIV is the most powerful known risk factor predisposing for Mycobacterium tuberculosis infection and progression to active disease, which increases the risk of latent TB reactivation 20-fold. TB is also the most common cause of AIDS-related death. Thus, M. tuberculosis and HIV act in synergy, accelerating the decline of immunological functions and leading to subsequent death if untreated. The mechanisms behind the breakdown of the immune defense of the co-infected individual are not well known. The aim of this review is to highlight immunological events that may accelerate the... (More)
Tuberculosis (TB) and HIV co-infections place an immense burden on health care systems and pose particular diagnostic and therapeutic challenges. Infection with HIV is the most powerful known risk factor predisposing for Mycobacterium tuberculosis infection and progression to active disease, which increases the risk of latent TB reactivation 20-fold. TB is also the most common cause of AIDS-related death. Thus, M. tuberculosis and HIV act in synergy, accelerating the decline of immunological functions and leading to subsequent death if untreated. The mechanisms behind the breakdown of the immune defense of the co-infected individual are not well known. The aim of this review is to highlight immunological events that may accelerate the development of one of the two diseases in the presence of the co-infecting organism. We also review possible animal models for studies of the interaction of the two pathogens, and describe gaps in knowledge and needs for future studies to develop preventive measures against the two diseases. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS Pathogens
volume
8
issue
2
publisher
Public Library of Science
external identifiers
  • wos:000300728100004
  • scopus:84860908291
ISSN
1553-7366
DOI
10.1371/journal.ppat.1002464
language
English
LU publication?
yes
id
bcd3b862-441f-46d9-b27b-1bf5db5efc50 (old id 2403114)
date added to LUP
2012-04-02 09:26:59
date last changed
2017-10-08 03:02:27
@article{bcd3b862-441f-46d9-b27b-1bf5db5efc50,
  abstract     = {Tuberculosis (TB) and HIV co-infections place an immense burden on health care systems and pose particular diagnostic and therapeutic challenges. Infection with HIV is the most powerful known risk factor predisposing for Mycobacterium tuberculosis infection and progression to active disease, which increases the risk of latent TB reactivation 20-fold. TB is also the most common cause of AIDS-related death. Thus, M. tuberculosis and HIV act in synergy, accelerating the decline of immunological functions and leading to subsequent death if untreated. The mechanisms behind the breakdown of the immune defense of the co-infected individual are not well known. The aim of this review is to highlight immunological events that may accelerate the development of one of the two diseases in the presence of the co-infecting organism. We also review possible animal models for studies of the interaction of the two pathogens, and describe gaps in knowledge and needs for future studies to develop preventive measures against the two diseases.},
  author       = {Pawlowski, Andrzej and Jansson, Marianne and Skold, Markus and Rottenberg, Martin E. and Kallenius, Gunilla},
  issn         = {1553-7366},
  language     = {eng},
  number       = {2},
  publisher    = {Public Library of Science},
  series       = {PLoS Pathogens},
  title        = {Tuberculosis and HIV Co-Infection},
  url          = {http://dx.doi.org/10.1371/journal.ppat.1002464},
  volume       = {8},
  year         = {2012},
}