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Relation between reduction of foveal thickness and visual acuity in diabetic macular edema treated with intravitreal triamcinolone

Larsson, Jörgen LU ; Zhu, MD; Sutter, F and Gillies, MC (2005) In American Journal of Ophthalmology 139(5). p.802-806
Abstract
PURPOSE: To evaluate the correlation between improvement in visual acuity and the reduction of foveal thickness after a single intravitreal injection of 4 mg of triamcinolone in diabetic macular edema. DESIGN: Prospective, interventional, nonrandomized clinical trial. METHOD: PATIENTS: In a prospective study 24 eyes with diabetic macular edema were treated with an intravitreal injection of 4 mg of triamcinolone acetonide. MAIN OUTCOME MEASURES: Best,corrected logMAR visual acuity and optical coherence tomography were performed at baseline and 3 months after the treatment. RESULTS: At baseline the average foveal thickness was 462 ± 154 μ m (95% confidence interval, 397-527 μ m) and at 3 months 257 ± 114 μ m (95%... (More)
PURPOSE: To evaluate the correlation between improvement in visual acuity and the reduction of foveal thickness after a single intravitreal injection of 4 mg of triamcinolone in diabetic macular edema. DESIGN: Prospective, interventional, nonrandomized clinical trial. METHOD: PATIENTS: In a prospective study 24 eyes with diabetic macular edema were treated with an intravitreal injection of 4 mg of triamcinolone acetonide. MAIN OUTCOME MEASURES: Best,corrected logMAR visual acuity and optical coherence tomography were performed at baseline and 3 months after the treatment. RESULTS: At baseline the average foveal thickness was 462 &PLUSMN; 154 μ m (95% confidence interval, 397-527 μ m) and at 3 months 257 &PLUSMN; 114 μ m (95% confidence interval, 209-305 μ m) (P < .0001). The best-corrected logMAR average visual acuity was 60.5 &PLUSMN; 10.5 (95% confidence interval, 56.0-65.0) ETDRS letters at base, line compared with 65.5 &PLUSMN; 11.1 (95% confidence interval, 60.8-70.1) 3 months after the injection (P = .0001). There was no correlation between the improvement in visual acuity and the reduction of foveal thickness (r = 0.054, P = .8), but there was a correlation between reduction in foveal thickness and the age of the patients (r = 0.53, P = .008). CONCLUSION: A single injection of 4 mg of intravitreal triamcinolone acetonide effectively reduces the foveal thickness in diabetic macular edema and improves visual acuity, but there does not appear to be a strong correlation between the reduction of foveal thickness and the improvement in visual acuity. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
American Journal of Ophthalmology
volume
139
issue
5
pages
802 - 806
publisher
Elsevier
external identifiers
  • pmid:15860283
  • wos:000228950500005
  • scopus:18144381156
ISSN
1879-1891
DOI
10.1016/j.ajo.2004.12.054
language
English
LU publication?
yes
id
348a70a5-4cb4-44b2-909b-2c7780ec0776 (old id 240668)
date added to LUP
2007-08-23 16:45:03
date last changed
2017-04-16 04:17:43
@article{348a70a5-4cb4-44b2-909b-2c7780ec0776,
  abstract     = {PURPOSE: To evaluate the correlation between improvement in visual acuity and the reduction of foveal thickness after a single intravitreal injection of 4 mg of triamcinolone in diabetic macular edema. DESIGN: Prospective, interventional, nonrandomized clinical trial. METHOD: PATIENTS: In a prospective study 24 eyes with diabetic macular edema were treated with an intravitreal injection of 4 mg of triamcinolone acetonide. MAIN OUTCOME MEASURES: Best,corrected logMAR visual acuity and optical coherence tomography were performed at baseline and 3 months after the treatment. RESULTS: At baseline the average foveal thickness was 462 &amp;PLUSMN; 154 μ m (95% confidence interval, 397-527 μ m) and at 3 months 257 &amp;PLUSMN; 114 μ m (95% confidence interval, 209-305 μ m) (P &lt; .0001). The best-corrected logMAR average visual acuity was 60.5 &amp;PLUSMN; 10.5 (95% confidence interval, 56.0-65.0) ETDRS letters at base, line compared with 65.5 &amp;PLUSMN; 11.1 (95% confidence interval, 60.8-70.1) 3 months after the injection (P = .0001). There was no correlation between the improvement in visual acuity and the reduction of foveal thickness (r = 0.054, P = .8), but there was a correlation between reduction in foveal thickness and the age of the patients (r = 0.53, P = .008). CONCLUSION: A single injection of 4 mg of intravitreal triamcinolone acetonide effectively reduces the foveal thickness in diabetic macular edema and improves visual acuity, but there does not appear to be a strong correlation between the reduction of foveal thickness and the improvement in visual acuity.},
  author       = {Larsson, Jörgen and Zhu, MD and Sutter, F and Gillies, MC},
  issn         = {1879-1891},
  language     = {eng},
  number       = {5},
  pages        = {802--806},
  publisher    = {Elsevier},
  series       = {American Journal of Ophthalmology},
  title        = {Relation between reduction of foveal thickness and visual acuity in diabetic macular edema treated with intravitreal triamcinolone},
  url          = {http://dx.doi.org/10.1016/j.ajo.2004.12.054},
  volume       = {139},
  year         = {2005},
}