A tetravalent meningococcal serogroups A, C, W-135, and Y tetanus toxoid conjugate vaccine is immunogenic and well-tolerated when co-administered with Twinrix (R) in subjects aged 11-17 years: An open, randomised, controlled trial
(2012) In Vaccine 30(4). p.774-783- Abstract
- The co-administration of the tetravalent meningococcal conjugate vaccine, MenACWY-TT, with a licensed hepatitis A and B vaccine, HepA/B (Twinrix (R)), was compared to their separate administration in this open, randomised, controlled study. Healthy subjects 11-17 years of age (n = 611) were randomised (3:1:1) to receive both vaccines, MenACWY-TT alone or HepA/B alone. The co-administration of both vaccines was shown to be non-inferior to their individual administration. At seven months after the first vaccination, 99.4-100% of the subjects who received both vaccines co-administered showed seroprotection against all meningococcal serogroups and at least 99.1% of them were seropositive for hepatitis A and seroprotected against hepatitis B.... (More)
- The co-administration of the tetravalent meningococcal conjugate vaccine, MenACWY-TT, with a licensed hepatitis A and B vaccine, HepA/B (Twinrix (R)), was compared to their separate administration in this open, randomised, controlled study. Healthy subjects 11-17 years of age (n = 611) were randomised (3:1:1) to receive both vaccines, MenACWY-TT alone or HepA/B alone. The co-administration of both vaccines was shown to be non-inferior to their individual administration. At seven months after the first vaccination, 99.4-100% of the subjects who received both vaccines co-administered showed seroprotection against all meningococcal serogroups and at least 99.1% of them were seropositive for hepatitis A and seroprotected against hepatitis B. This study suggests that MenACWY-TT vaccine could be co-administered with HepA/B without adversely impacting the immunogenicity, safety and reactogenicity of either of the vaccines. (C) 2011 Elsevier Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2409606
- author
- Ostergaard, Lars ; Silfverdal, Sven-Arne ; Berglund, Johan ; Flodmark, Carl-Erik LU ; West, Christina ; Bianco, Veronique ; Baine, Yaela and Miller, Jacqueline M.
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Co-administration, Tetravalent meningococcal vaccine, Conjugate vaccine, Twinrix (R), Adolescent
- in
- Vaccine
- volume
- 30
- issue
- 4
- pages
- 774 - 783
- publisher
- Elsevier
- external identifiers
-
- wos:000300263700012
- scopus:84855341472
- pmid:22107850
- ISSN
- 1873-2518
- DOI
- 10.1016/j.vaccine.2011.11.051
- language
- English
- LU publication?
- yes
- id
- 0b9eb247-156e-4873-8c33-8300e3796420 (old id 2409606)
- date added to LUP
- 2016-04-01 10:22:09
- date last changed
- 2022-03-04 18:51:46
@article{0b9eb247-156e-4873-8c33-8300e3796420, abstract = {{The co-administration of the tetravalent meningococcal conjugate vaccine, MenACWY-TT, with a licensed hepatitis A and B vaccine, HepA/B (Twinrix (R)), was compared to their separate administration in this open, randomised, controlled study. Healthy subjects 11-17 years of age (n = 611) were randomised (3:1:1) to receive both vaccines, MenACWY-TT alone or HepA/B alone. The co-administration of both vaccines was shown to be non-inferior to their individual administration. At seven months after the first vaccination, 99.4-100% of the subjects who received both vaccines co-administered showed seroprotection against all meningococcal serogroups and at least 99.1% of them were seropositive for hepatitis A and seroprotected against hepatitis B. This study suggests that MenACWY-TT vaccine could be co-administered with HepA/B without adversely impacting the immunogenicity, safety and reactogenicity of either of the vaccines. (C) 2011 Elsevier Ltd. All rights reserved.}}, author = {{Ostergaard, Lars and Silfverdal, Sven-Arne and Berglund, Johan and Flodmark, Carl-Erik and West, Christina and Bianco, Veronique and Baine, Yaela and Miller, Jacqueline M.}}, issn = {{1873-2518}}, keywords = {{Co-administration; Tetravalent meningococcal vaccine; Conjugate vaccine; Twinrix (R); Adolescent}}, language = {{eng}}, number = {{4}}, pages = {{774--783}}, publisher = {{Elsevier}}, series = {{Vaccine}}, title = {{A tetravalent meningococcal serogroups A, C, W-135, and Y tetanus toxoid conjugate vaccine is immunogenic and well-tolerated when co-administered with Twinrix (R) in subjects aged 11-17 years: An open, randomised, controlled trial}}, url = {{http://dx.doi.org/10.1016/j.vaccine.2011.11.051}}, doi = {{10.1016/j.vaccine.2011.11.051}}, volume = {{30}}, year = {{2012}}, }