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A tetravalent meningococcal serogroups A, C, W-135, and Y tetanus toxoid conjugate vaccine is immunogenic and well-tolerated when co-administered with Twinrix (R) in subjects aged 11-17 years: An open, randomised, controlled trial

Ostergaard, Lars; Silfverdal, Sven-Arne; Berglund, Johan; Flodmark, Carl-Erik LU ; West, Christina; Bianco, Veronique; Baine, Yaela and Miller, Jacqueline M. (2012) In Vaccine 30(4). p.774-783
Abstract
The co-administration of the tetravalent meningococcal conjugate vaccine, MenACWY-TT, with a licensed hepatitis A and B vaccine, HepA/B (Twinrix (R)), was compared to their separate administration in this open, randomised, controlled study. Healthy subjects 11-17 years of age (n = 611) were randomised (3:1:1) to receive both vaccines, MenACWY-TT alone or HepA/B alone. The co-administration of both vaccines was shown to be non-inferior to their individual administration. At seven months after the first vaccination, 99.4-100% of the subjects who received both vaccines co-administered showed seroprotection against all meningococcal serogroups and at least 99.1% of them were seropositive for hepatitis A and seroprotected against hepatitis B.... (More)
The co-administration of the tetravalent meningococcal conjugate vaccine, MenACWY-TT, with a licensed hepatitis A and B vaccine, HepA/B (Twinrix (R)), was compared to their separate administration in this open, randomised, controlled study. Healthy subjects 11-17 years of age (n = 611) were randomised (3:1:1) to receive both vaccines, MenACWY-TT alone or HepA/B alone. The co-administration of both vaccines was shown to be non-inferior to their individual administration. At seven months after the first vaccination, 99.4-100% of the subjects who received both vaccines co-administered showed seroprotection against all meningococcal serogroups and at least 99.1% of them were seropositive for hepatitis A and seroprotected against hepatitis B. This study suggests that MenACWY-TT vaccine could be co-administered with HepA/B without adversely impacting the immunogenicity, safety and reactogenicity of either of the vaccines. (C) 2011 Elsevier Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Co-administration, Tetravalent meningococcal vaccine, Conjugate vaccine, Twinrix (R), Adolescent
in
Vaccine
volume
30
issue
4
pages
774 - 783
publisher
Elsevier
external identifiers
  • wos:000300263700012
  • scopus:84855341472
ISSN
1873-2518
DOI
10.1016/j.vaccine.2011.11.051
language
English
LU publication?
yes
id
0b9eb247-156e-4873-8c33-8300e3796420 (old id 2409606)
date added to LUP
2012-04-02 09:30:59
date last changed
2017-04-09 03:10:56
@article{0b9eb247-156e-4873-8c33-8300e3796420,
  abstract     = {The co-administration of the tetravalent meningococcal conjugate vaccine, MenACWY-TT, with a licensed hepatitis A and B vaccine, HepA/B (Twinrix (R)), was compared to their separate administration in this open, randomised, controlled study. Healthy subjects 11-17 years of age (n = 611) were randomised (3:1:1) to receive both vaccines, MenACWY-TT alone or HepA/B alone. The co-administration of both vaccines was shown to be non-inferior to their individual administration. At seven months after the first vaccination, 99.4-100% of the subjects who received both vaccines co-administered showed seroprotection against all meningococcal serogroups and at least 99.1% of them were seropositive for hepatitis A and seroprotected against hepatitis B. This study suggests that MenACWY-TT vaccine could be co-administered with HepA/B without adversely impacting the immunogenicity, safety and reactogenicity of either of the vaccines. (C) 2011 Elsevier Ltd. All rights reserved.},
  author       = {Ostergaard, Lars and Silfverdal, Sven-Arne and Berglund, Johan and Flodmark, Carl-Erik and West, Christina and Bianco, Veronique and Baine, Yaela and Miller, Jacqueline M.},
  issn         = {1873-2518},
  keyword      = {Co-administration,Tetravalent meningococcal vaccine,Conjugate vaccine,Twinrix (R),Adolescent},
  language     = {eng},
  number       = {4},
  pages        = {774--783},
  publisher    = {Elsevier},
  series       = {Vaccine},
  title        = {A tetravalent meningococcal serogroups A, C, W-135, and Y tetanus toxoid conjugate vaccine is immunogenic and well-tolerated when co-administered with Twinrix (R) in subjects aged 11-17 years: An open, randomised, controlled trial},
  url          = {http://dx.doi.org/10.1016/j.vaccine.2011.11.051},
  volume       = {30},
  year         = {2012},
}