Catabolism of prothrombin-chylomicron complexes in vivo in the rat
(1996) In Thrombosis Research 81(2). p.203-212- Abstract
- The metabolism in vivo in the rat of 125I-prothrombin-chylomicron complexes was compared to that of free 125I-prothrombin injected in saline or together with chyle chylomicrons. The group that obtained 125I-prothrombin-chylomicron complexes exhibited a faster initial decrease of plasma 125I-prothrombin, a higher radioactivity in the liver and more trichloroacetic acid soluble 125I in plasma than in the other groups that did not differ. In the group injected with 125I-prothrombin-chylomicron complexes, 4% was in the HDL, 0.7% LDL, and 0.8% in VLDL 2 hours after injection. The data thus indicate that although most of the 125I-prothrombin is released during the metabolism of the prothrombin-chylomicron complexes, some is rapidly degraded and... (More)
- The metabolism in vivo in the rat of 125I-prothrombin-chylomicron complexes was compared to that of free 125I-prothrombin injected in saline or together with chyle chylomicrons. The group that obtained 125I-prothrombin-chylomicron complexes exhibited a faster initial decrease of plasma 125I-prothrombin, a higher radioactivity in the liver and more trichloroacetic acid soluble 125I in plasma than in the other groups that did not differ. In the group injected with 125I-prothrombin-chylomicron complexes, 4% was in the HDL, 0.7% LDL, and 0.8% in VLDL 2 hours after injection. The data thus indicate that although most of the 125I-prothrombin is released during the metabolism of the prothrombin-chylomicron complexes, some is rapidly degraded and some is transferred to plasma lipoproteins and remains circulating for a considerable time period. The observations demonstrate that binding to chylomicrons influences the catabolism of prothrombin in vivo. Since chylomicrons did not influence the clearance of simultaneously injected free 125I-prothrombin, the prothrombin binding to chylomicrons or chylomicron remnants in vivo may, however, be too slow to influence the prothrombin catabolism under normal conditions (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2428c782-c4b2-4e0e-a11f-4fbdbbf9c54e
- author
- Xu, Ning LU ; Zhou, Li LU ; Öhlin, Ann-Kristin LU and Nilsson, Åke LU
- publishing date
- 1996-01-15
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Thrombosis Research
- volume
- 81
- issue
- 2
- article number
- 8822135
- pages
- 203 - 212
- publisher
- Elsevier
- external identifiers
-
- pmid:8822135
- scopus:0029877168
- ISSN
- 1879-2472
- DOI
- 10.1016/0049-3848(95)00237-5
- language
- Swedish
- LU publication?
- no
- id
- 2428c782-c4b2-4e0e-a11f-4fbdbbf9c54e
- date added to LUP
- 2019-06-20 13:53:16
- date last changed
- 2022-01-31 22:13:17
@article{2428c782-c4b2-4e0e-a11f-4fbdbbf9c54e,
abstract = {{The metabolism in vivo in the rat of 125I-prothrombin-chylomicron complexes was compared to that of free 125I-prothrombin injected in saline or together with chyle chylomicrons. The group that obtained 125I-prothrombin-chylomicron complexes exhibited a faster initial decrease of plasma 125I-prothrombin, a higher radioactivity in the liver and more trichloroacetic acid soluble 125I in plasma than in the other groups that did not differ. In the group injected with 125I-prothrombin-chylomicron complexes, 4% was in the HDL, 0.7% LDL, and 0.8% in VLDL 2 hours after injection. The data thus indicate that although most of the 125I-prothrombin is released during the metabolism of the prothrombin-chylomicron complexes, some is rapidly degraded and some is transferred to plasma lipoproteins and remains circulating for a considerable time period. The observations demonstrate that binding to chylomicrons influences the catabolism of prothrombin in vivo. Since chylomicrons did not influence the clearance of simultaneously injected free 125I-prothrombin, the prothrombin binding to chylomicrons or chylomicron remnants in vivo may, however, be too slow to influence the prothrombin catabolism under normal conditions}},
author = {{Xu, Ning and Zhou, Li and Öhlin, Ann-Kristin and Nilsson, Åke}},
issn = {{1879-2472}},
language = {{swe}},
month = {{01}},
number = {{2}},
pages = {{203--212}},
publisher = {{Elsevier}},
series = {{Thrombosis Research}},
title = {{Catabolism of prothrombin-chylomicron complexes in vivo in the rat}},
url = {{http://dx.doi.org/10.1016/0049-3848(95)00237-5}},
doi = {{10.1016/0049-3848(95)00237-5}},
volume = {{81}},
year = {{1996}},
}