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Catabolism of prothrombin-chylomicron complexes in vivo in the rat

Xu, Ning LU ; Zhou, Li LU ; Öhlin, Ann-Kristin LU and Nilsson, Åke LU (1996) In Thrombosis Research 81(2). p.203-212
Abstract (Swedish)
The metabolism in vivo in the rat of 125I-prothrombin-chylomicron complexes was compared to that of free 125I-prothrombin injected in saline or together with chyle chylomicrons. The group that obtained 125I-prothrombin-chylomicron complexes exhibited a faster initial decrease of plasma 125I-prothrombin, a higher radioactivity in the liver and more trichloroacetic acid soluble 125I in plasma than in the other groups that did not differ. In the group injected with 125I-prothrombin-chylomicron complexes, 4% was in the HDL, 0.7% LDL, and 0.8% in VLDL 2 hours after injection. The data thus indicate that although most of the 125I-prothrombin is released during the metabolism of the prothrombin-chylomicron complexes, some is rapidly degraded and... (More)
The metabolism in vivo in the rat of 125I-prothrombin-chylomicron complexes was compared to that of free 125I-prothrombin injected in saline or together with chyle chylomicrons. The group that obtained 125I-prothrombin-chylomicron complexes exhibited a faster initial decrease of plasma 125I-prothrombin, a higher radioactivity in the liver and more trichloroacetic acid soluble 125I in plasma than in the other groups that did not differ. In the group injected with 125I-prothrombin-chylomicron complexes, 4% was in the HDL, 0.7% LDL, and 0.8% in VLDL 2 hours after injection. The data thus indicate that although most of the 125I-prothrombin is released during the metabolism of the prothrombin-chylomicron complexes, some is rapidly degraded and some is transferred to plasma lipoproteins and remains circulating for a considerable time period. The observations demonstrate that binding to chylomicrons influences the catabolism of prothrombin in vivo. Since chylomicrons did not influence the clearance of simultaneously injected free 125I-prothrombin, the prothrombin binding to chylomicrons or chylomicron remnants in vivo may, however, be too slow to influence the prothrombin catabolism under normal conditions (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Thrombosis Research
volume
81
issue
2
article number
8822135
pages
203 - 212
publisher
Elsevier Ltd
external identifiers
  • pmid:8822135
ISSN
1879-2472
DOI
10.1016/0049-3848(95)00237-5
language
Swedish
LU publication?
no
id
2428c782-c4b2-4e0e-a11f-4fbdbbf9c54e
date added to LUP
2019-06-20 13:53:16
date last changed
2020-02-12 04:01:41
@article{2428c782-c4b2-4e0e-a11f-4fbdbbf9c54e,
  abstract     = {The metabolism in vivo in the rat of 125I-prothrombin-chylomicron complexes was compared to that of free 125I-prothrombin injected in saline or together with chyle chylomicrons. The group that obtained 125I-prothrombin-chylomicron complexes exhibited a faster initial decrease of plasma 125I-prothrombin, a higher radioactivity in the liver and more trichloroacetic acid soluble 125I in plasma than in the other groups that did not differ. In the group injected with 125I-prothrombin-chylomicron complexes, 4% was in the HDL, 0.7% LDL, and 0.8% in VLDL 2 hours after injection. The data thus indicate that although most of the 125I-prothrombin is released during the metabolism of the prothrombin-chylomicron complexes, some is rapidly degraded and some is transferred to plasma lipoproteins and remains circulating for a considerable time period. The observations demonstrate that binding to chylomicrons influences the catabolism of prothrombin in vivo. Since chylomicrons did not influence the clearance of simultaneously injected free 125I-prothrombin, the prothrombin binding to chylomicrons or chylomicron remnants in vivo may, however, be too slow to influence the prothrombin catabolism under normal conditions},
  author       = {Xu, Ning and Zhou, Li and Öhlin, Ann-Kristin and Nilsson, Åke},
  issn         = {1879-2472},
  language     = {swe},
  month        = {01},
  number       = {2},
  pages        = {203--212},
  publisher    = {Elsevier Ltd},
  series       = {Thrombosis Research},
  title        = {Catabolism of prothrombin-chylomicron complexes in vivo in the rat},
  url          = {http://dx.doi.org/10.1016/0049-3848(95)00237-5},
  doi          = {10.1016/0049-3848(95)00237-5},
  volume       = {81},
  year         = {1996},
}