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Submucosal glands in the columnar-lined oesophagus: evidence of an association with metaplasia and neosquamous epithelium.

Lörinc, Ester LU and Öberg, Stefan LU (2012) In Histopathology 61(1). p.53-58
Abstract
Aim: A multipotential stem cell, possibly located in the submucosal gland ducts, has been suggested as the origin of metaplastic mucosa in the oesophagus. The topographic distribution of these glands and their excretory ducts (SMG) within the columnar lined oesophagus (CLO) is largely unknown. The aim of this study was to examine the distribution of SMG in relation to the type of overlying epithelium in patients with CLO.



Methods and results: Seven oesophageal resection specimens were examined histologically in toto. The median frequency of SMG was similar in the metaplastic segments (0.12 SMG/mm) and the normal squamous segments (0.10 SMG/mm). Within the metaplastic segments, the median frequency of SMG beneath the... (More)
Aim: A multipotential stem cell, possibly located in the submucosal gland ducts, has been suggested as the origin of metaplastic mucosa in the oesophagus. The topographic distribution of these glands and their excretory ducts (SMG) within the columnar lined oesophagus (CLO) is largely unknown. The aim of this study was to examine the distribution of SMG in relation to the type of overlying epithelium in patients with CLO.



Methods and results: Seven oesophageal resection specimens were examined histologically in toto. The median frequency of SMG was similar in the metaplastic segments (0.12 SMG/mm) and the normal squamous segments (0.10 SMG/mm). Within the metaplastic segments, the median frequency of SMG beneath the squamous islands was significantly higher than that observed under the columnar lined parts (0.22 versus 0.08 SMG/mm, P = 0.046), There was a strong accumulation of SMG at the squamo-columnar transition zones (0.53 SMG/mm), which was significantly greater than that found in the columnar and squamous parts (P = 0.001 and 0.002, respectively).



Conclusions: The relative accumulation of SMG beneath squamous islands and the squamo-columnar junctions within the metaplastic segment supports the hypothesis that both metaplastic columnar mucosa and neosquamous epithelium originate from a progenitor in the SMG. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Histopathology
volume
61
issue
1
pages
53 - 58
publisher
Wiley-Blackwell
external identifiers
  • wos:000305604900007
  • pmid:22458702
  • scopus:84862867723
ISSN
0309-0167
DOI
10.1111/j.1365-2559.2012.04180.x
language
English
LU publication?
yes
id
80accc4c-9a70-4fdb-bb2d-e12b49e02527 (old id 2431347)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22458702?dopt=Abstract
date added to LUP
2012-04-03 14:09:18
date last changed
2017-10-29 04:30:29
@article{80accc4c-9a70-4fdb-bb2d-e12b49e02527,
  abstract     = {Aim: A multipotential stem cell, possibly located in the submucosal gland ducts, has been suggested as the origin of metaplastic mucosa in the oesophagus. The topographic distribution of these glands and their excretory ducts (SMG) within the columnar lined oesophagus (CLO) is largely unknown. The aim of this study was to examine the distribution of SMG in relation to the type of overlying epithelium in patients with CLO. <br/><br>
<br/><br>
Methods and results: Seven oesophageal resection specimens were examined histologically in toto. The median frequency of SMG was similar in the metaplastic segments (0.12 SMG/mm) and the normal squamous segments (0.10 SMG/mm). Within the metaplastic segments, the median frequency of SMG beneath the squamous islands was significantly higher than that observed under the columnar lined parts (0.22 versus 0.08 SMG/mm, P = 0.046), There was a strong accumulation of SMG at the squamo-columnar transition zones (0.53 SMG/mm), which was significantly greater than that found in the columnar and squamous parts (P = 0.001 and 0.002, respectively). <br/><br>
<br/><br>
Conclusions: The relative accumulation of SMG beneath squamous islands and the squamo-columnar junctions within the metaplastic segment supports the hypothesis that both metaplastic columnar mucosa and neosquamous epithelium originate from a progenitor in the SMG.},
  author       = {Lörinc, Ester and Öberg, Stefan},
  issn         = {0309-0167},
  language     = {eng},
  number       = {1},
  pages        = {53--58},
  publisher    = {Wiley-Blackwell},
  series       = {Histopathology},
  title        = {Submucosal glands in the columnar-lined oesophagus: evidence of an association with metaplasia and neosquamous epithelium.},
  url          = {http://dx.doi.org/10.1111/j.1365-2559.2012.04180.x},
  volume       = {61},
  year         = {2012},
}