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Duration and morbidity of chronic immune thrombocytopenic purpura in children: Five-year follow-up of a Nordic cohort.

Rosthøj, Steen; Rajantie, Jukka; Treutiger, Iris; Zeller, Bernward; Tedgård, Ulf LU and Henter, Jan-Inge (2012) In Acta paediatrica (Oslo, Norway : 1992) 101(7). p.761-766
Abstract
Aim: To describe the clinical course, morbidity and platelet recovery in an unselected Nordic cohort of children with chronic Immune Thrombocytopenic Purpura (ITP).



Methods: Prospective 5-year follow-up of 96 children with ITP lasting more than 6 months, with reporting of hospital admissions, severity of bleeding episodes, and stabilization of platelet counts above 20, 50 and 150 x 10(9) /L.



Results: The estimated 5-year recovery rate was 52%; exclusion of 12 splenectomized children did not change the estimate. Events eliciting admission to hospital occurred in 39 (41%). Major hemorrhages occurred in 8 children (8%), including a non-fatal intracranial hemorrhage in one child (1%). The overall... (More)
Aim: To describe the clinical course, morbidity and platelet recovery in an unselected Nordic cohort of children with chronic Immune Thrombocytopenic Purpura (ITP).



Methods: Prospective 5-year follow-up of 96 children with ITP lasting more than 6 months, with reporting of hospital admissions, severity of bleeding episodes, and stabilization of platelet counts above 20, 50 and 150 x 10(9) /L.



Results: The estimated 5-year recovery rate was 52%; exclusion of 12 splenectomized children did not change the estimate. Events eliciting admission to hospital occurred in 39 (41%). Major hemorrhages occurred in 8 children (8%), including a non-fatal intracranial hemorrhage in one child (1%). The overall admission rate was 0.4 per year of thrombocytopenia, decreasing during follow-up as thrombocytopenia converted to milder degrees. Early recovery within 2 years of diagnosis occurred in 35%, was associated with low morbidity, and was more likely in young children with abrupt onset of symptoms.



Conclusion: In a Nordic cohort of children with chronic ITP one half had recovered 5 years after diagnosis, more than half never required hospitalization, and less than 10% experienced serious bleeding episodes, always with a platelet count <20 x 10(9) /L. Aggressive management can be restricted to the minority of children with continuing severe thrombocytopenia and frequent, clinically significant bleeding events. © 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica. (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta paediatrica (Oslo, Norway : 1992)
volume
101
issue
7
pages
761 - 766
publisher
Taylor & Francis
external identifiers
  • WOS:000304715200029
  • PMID:22429281
  • Scopus:84861830904
ISSN
1651-2227
DOI
10.1111/j.1651-2227.2012.02671.x
language
English
LU publication?
no
id
0c86b106-b57f-45d7-8eb4-be9e91e54459 (old id 2431633)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22429281?dopt=Abstract
date added to LUP
2012-04-03 12:21:56
date last changed
2017-02-17 13:27:01
@article{0c86b106-b57f-45d7-8eb4-be9e91e54459,
  abstract     = {Aim: To describe the clinical course, morbidity and platelet recovery in an unselected Nordic cohort of children with chronic Immune Thrombocytopenic Purpura (ITP). <br/><br>
<br/><br>
Methods: Prospective 5-year follow-up of 96 children with ITP lasting more than 6 months, with reporting of hospital admissions, severity of bleeding episodes, and stabilization of platelet counts above 20, 50 and 150 x 10(9) /L. <br/><br>
<br/><br>
Results: The estimated 5-year recovery rate was 52%; exclusion of 12 splenectomized children did not change the estimate. Events eliciting admission to hospital occurred in 39 (41%). Major hemorrhages occurred in 8 children (8%), including a non-fatal intracranial hemorrhage in one child (1%). The overall admission rate was 0.4 per year of thrombocytopenia, decreasing during follow-up as thrombocytopenia converted to milder degrees. Early recovery within 2 years of diagnosis occurred in 35%, was associated with low morbidity, and was more likely in young children with abrupt onset of symptoms. <br/><br>
<br/><br>
Conclusion: In a Nordic cohort of children with chronic ITP one half had recovered 5 years after diagnosis, more than half never required hospitalization, and less than 10% experienced serious bleeding episodes, always with a platelet count &lt;20 x 10(9) /L. Aggressive management can be restricted to the minority of children with continuing severe thrombocytopenia and frequent, clinically significant bleeding events. © 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.},
  author       = {Rosthøj, Steen and Rajantie, Jukka and Treutiger, Iris and Zeller, Bernward and Tedgård, Ulf and Henter, Jan-Inge},
  issn         = {1651-2227},
  language     = {eng},
  number       = {7},
  pages        = {761--766},
  publisher    = {Taylor & Francis},
  series       = {Acta paediatrica (Oslo, Norway : 1992)},
  title        = {Duration and morbidity of chronic immune thrombocytopenic purpura in children: Five-year follow-up of a Nordic cohort.},
  url          = {http://dx.doi.org/10.1111/j.1651-2227.2012.02671.x},
  volume       = {101},
  year         = {2012},
}