Characteristics of Androgen Deficiency in Late-Onset Hypogonadism: Results from the European Male Aging Study (EMAS).
(2012) In The Journal of clinical endocrinology and metabolism 97(5). p.1508-1516- Abstract
- Context:Late-onset hypogonadism (LOH) has been defined as a syndrome in middle-aged and elderly men reporting symptoms in the presence of low testosterone (T).
Objective:The objective of the study was to seek objective biochemical and end-organ evidence of androgen deficiency in men classified as having LOH according to our previously published criteria.
Design, Setting, and Participants:The design of the study included cross-sectional data from the European Male Aging Study on 2966 community-dwelling men aged 40-79 years in eight European countries.
Main Outcome Measure(s):Waist circumference, body mass index, muscle mass, estimated heel bone mineral density (eBMD), hemoglobin,... (More) - Context:Late-onset hypogonadism (LOH) has been defined as a syndrome in middle-aged and elderly men reporting symptoms in the presence of low testosterone (T).
Objective:The objective of the study was to seek objective biochemical and end-organ evidence of androgen deficiency in men classified as having LOH according to our previously published criteria.
Design, Setting, and Participants:The design of the study included cross-sectional data from the European Male Aging Study on 2966 community-dwelling men aged 40-79 years in eight European countries.
Main Outcome Measure(s):Waist circumference, body mass index, muscle mass, estimated heel bone mineral density (eBMD), hemoglobin, insulin sensitivity, physical activity, metabolic syndrome, insulin resistance index, and cardiovascular disease were measured.
Results:Sixty-three men (2.1%) were classified as having LOH: 36 moderate and 27 severe. They were older and more obese than eugonadal men and had, in proportion to the graded T deficiency, lower muscle mass, eBMD, and hemoglobin, with poorer general health. Both moderate and severe LOH was associated with lower hemoglobin, mid-upper arm circumference, eBMD, physical function (measured by the Short Form-36 questionnaire), slower gait speed and poorer general health. Only men with severe LOH showed significant associations with larger waist circumference (β= 1.93cm; 0.04-3.81), insulin resistance (β= 2.81; 1.39-4.23), and the metabolic syndrome (odds ratio 9.94; 2.73-36.22) after adjustments for confounders. Men with low testosterone only (irrespective of symptoms) showed lesser magnitudes of association with the same end points.
Conclusions:LOH is associated with multiple end-organ deficits compatible with androgen deficiency. These data support the existence of a syndrome of LOH in only a minority of aging men, especially those with T below 8 nmol/liter. (Less)
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https://lup.lub.lu.se/record/2431769
- author
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The Journal of clinical endocrinology and metabolism
- volume
- 97
- issue
- 5
- pages
- 1508 - 1516
- publisher
- Oxford University Press
- external identifiers
-
- wos:000303915900041
- pmid:22419720
- scopus:84860751541
- pmid:22419720
- ISSN
- 1945-7197
- DOI
- 10.1210/jc.2011-2513
- language
- English
- LU publication?
- yes
- id
- 5c02a673-d97c-479f-acfd-63c29e1ff802 (old id 2431769)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22419720?dopt=Abstract
- date added to LUP
- 2016-04-01 13:31:51
- date last changed
- 2022-04-14 01:36:41
@article{5c02a673-d97c-479f-acfd-63c29e1ff802,
abstract = {{Context:Late-onset hypogonadism (LOH) has been defined as a syndrome in middle-aged and elderly men reporting symptoms in the presence of low testosterone (T).<br/><br>
<br/><br>
Objective:The objective of the study was to seek objective biochemical and end-organ evidence of androgen deficiency in men classified as having LOH according to our previously published criteria.<br/><br>
<br/><br>
Design, Setting, and Participants:The design of the study included cross-sectional data from the European Male Aging Study on 2966 community-dwelling men aged 40-79 years in eight European countries.<br/><br>
<br/><br>
Main Outcome Measure(s):Waist circumference, body mass index, muscle mass, estimated heel bone mineral density (eBMD), hemoglobin, insulin sensitivity, physical activity, metabolic syndrome, insulin resistance index, and cardiovascular disease were measured.<br/><br>
<br/><br>
Results:Sixty-three men (2.1%) were classified as having LOH: 36 moderate and 27 severe. They were older and more obese than eugonadal men and had, in proportion to the graded T deficiency, lower muscle mass, eBMD, and hemoglobin, with poorer general health. Both moderate and severe LOH was associated with lower hemoglobin, mid-upper arm circumference, eBMD, physical function (measured by the Short Form-36 questionnaire), slower gait speed and poorer general health. Only men with severe LOH showed significant associations with larger waist circumference (β= 1.93cm; 0.04-3.81), insulin resistance (β= 2.81; 1.39-4.23), and the metabolic syndrome (odds ratio 9.94; 2.73-36.22) after adjustments for confounders. Men with low testosterone only (irrespective of symptoms) showed lesser magnitudes of association with the same end points.<br/><br>
<br/><br>
Conclusions:LOH is associated with multiple end-organ deficits compatible with androgen deficiency. These data support the existence of a syndrome of LOH in only a minority of aging men, especially those with T below 8 nmol/liter.}},
author = {{Tajar, Abdelouahid and Huhtaniemi, Ilpo T and O'Neill, Terence W and Finn, Joseph D and Pye, Stephen R and Lee, David M and Bartfai, György and Boonen, Steven and Casanueva, Felipe F F and Forti, Gianni and Giwercman, Aleksander and Han, Thang S and Kula, Krzysztof and Labrie, Fernand and Lean, Michael E J and Pendleton, Neil and Punab, Margus and Vanderschueren, Dirk and Wu, Frederick C W}},
issn = {{1945-7197}},
language = {{eng}},
number = {{5}},
pages = {{1508--1516}},
publisher = {{Oxford University Press}},
series = {{The Journal of clinical endocrinology and metabolism}},
title = {{Characteristics of Androgen Deficiency in Late-Onset Hypogonadism: Results from the European Male Aging Study (EMAS).}},
url = {{https://lup.lub.lu.se/search/files/3432150/2836016.pdf}},
doi = {{10.1210/jc.2011-2513}},
volume = {{97}},
year = {{2012}},
}