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Characteristics of Androgen Deficiency in Late-Onset Hypogonadism: Results from the European Male Aging Study (EMAS).

Tajar, Abdelouahid; Huhtaniemi, Ilpo T; O'Neill, Terence W; Finn, Joseph D; Pye, Stephen R; Lee, David M; Bartfai, György; Boonen, Steven; Casanueva, Felipe F F and Forti, Gianni, et al. (2012) In The Journal of clinical endocrinology and metabolism 97(5). p.1508-1516
Abstract
Context:Late-onset hypogonadism (LOH) has been defined as a syndrome in middle-aged and elderly men reporting symptoms in the presence of low testosterone (T).



Objective:The objective of the study was to seek objective biochemical and end-organ evidence of androgen deficiency in men classified as having LOH according to our previously published criteria.



Design, Setting, and Participants:The design of the study included cross-sectional data from the European Male Aging Study on 2966 community-dwelling men aged 40-79 years in eight European countries.



Main Outcome Measure(s):Waist circumference, body mass index, muscle mass, estimated heel bone mineral density (eBMD), hemoglobin,... (More)
Context:Late-onset hypogonadism (LOH) has been defined as a syndrome in middle-aged and elderly men reporting symptoms in the presence of low testosterone (T).



Objective:The objective of the study was to seek objective biochemical and end-organ evidence of androgen deficiency in men classified as having LOH according to our previously published criteria.



Design, Setting, and Participants:The design of the study included cross-sectional data from the European Male Aging Study on 2966 community-dwelling men aged 40-79 years in eight European countries.



Main Outcome Measure(s):Waist circumference, body mass index, muscle mass, estimated heel bone mineral density (eBMD), hemoglobin, insulin sensitivity, physical activity, metabolic syndrome, insulin resistance index, and cardiovascular disease were measured.



Results:Sixty-three men (2.1%) were classified as having LOH: 36 moderate and 27 severe. They were older and more obese than eugonadal men and had, in proportion to the graded T deficiency, lower muscle mass, eBMD, and hemoglobin, with poorer general health. Both moderate and severe LOH was associated with lower hemoglobin, mid-upper arm circumference, eBMD, physical function (measured by the Short Form-36 questionnaire), slower gait speed and poorer general health. Only men with severe LOH showed significant associations with larger waist circumference (β= 1.93cm; 0.04-3.81), insulin resistance (β= 2.81; 1.39-4.23), and the metabolic syndrome (odds ratio 9.94; 2.73-36.22) after adjustments for confounders. Men with low testosterone only (irrespective of symptoms) showed lesser magnitudes of association with the same end points.



Conclusions:LOH is associated with multiple end-organ deficits compatible with androgen deficiency. These data support the existence of a syndrome of LOH in only a minority of aging men, especially those with T below 8 nmol/liter. (Less)
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published
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The Journal of clinical endocrinology and metabolism
volume
97
issue
5
pages
1508 - 1516
publisher
The Endocrine Society
external identifiers
  • wos:000303915900041
  • pmid:22419720
  • scopus:84860751541
ISSN
1945-7197
DOI
10.1210/jc.2011-2513
language
English
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yes
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5c02a673-d97c-479f-acfd-63c29e1ff802 (old id 2431769)
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http://www.ncbi.nlm.nih.gov/pubmed/22419720?dopt=Abstract
date added to LUP
2012-04-03 11:12:57
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2017-11-19 03:47:04
@article{5c02a673-d97c-479f-acfd-63c29e1ff802,
  abstract     = {Context:Late-onset hypogonadism (LOH) has been defined as a syndrome in middle-aged and elderly men reporting symptoms in the presence of low testosterone (T).<br/><br>
<br/><br>
Objective:The objective of the study was to seek objective biochemical and end-organ evidence of androgen deficiency in men classified as having LOH according to our previously published criteria.<br/><br>
<br/><br>
Design, Setting, and Participants:The design of the study included cross-sectional data from the European Male Aging Study on 2966 community-dwelling men aged 40-79 years in eight European countries.<br/><br>
<br/><br>
Main Outcome Measure(s):Waist circumference, body mass index, muscle mass, estimated heel bone mineral density (eBMD), hemoglobin, insulin sensitivity, physical activity, metabolic syndrome, insulin resistance index, and cardiovascular disease were measured.<br/><br>
<br/><br>
Results:Sixty-three men (2.1%) were classified as having LOH: 36 moderate and 27 severe. They were older and more obese than eugonadal men and had, in proportion to the graded T deficiency, lower muscle mass, eBMD, and hemoglobin, with poorer general health. Both moderate and severe LOH was associated with lower hemoglobin, mid-upper arm circumference, eBMD, physical function (measured by the Short Form-36 questionnaire), slower gait speed and poorer general health. Only men with severe LOH showed significant associations with larger waist circumference (β= 1.93cm; 0.04-3.81), insulin resistance (β= 2.81; 1.39-4.23), and the metabolic syndrome (odds ratio 9.94; 2.73-36.22) after adjustments for confounders. Men with low testosterone only (irrespective of symptoms) showed lesser magnitudes of association with the same end points.<br/><br>
<br/><br>
Conclusions:LOH is associated with multiple end-organ deficits compatible with androgen deficiency. These data support the existence of a syndrome of LOH in only a minority of aging men, especially those with T below 8 nmol/liter.},
  author       = {Tajar, Abdelouahid and Huhtaniemi, Ilpo T and O'Neill, Terence W and Finn, Joseph D and Pye, Stephen R and Lee, David M and Bartfai, György and Boonen, Steven and Casanueva, Felipe F F and Forti, Gianni and Giwercman, Aleksander and Han, Thang S and Kula, Krzysztof and Labrie, Fernand and Lean, Michael E J and Pendleton, Neil and Punab, Margus and Vanderschueren, Dirk and Wu, Frederick C W},
  issn         = {1945-7197},
  language     = {eng},
  number       = {5},
  pages        = {1508--1516},
  publisher    = {The Endocrine Society},
  series       = {The Journal of clinical endocrinology and metabolism},
  title        = {Characteristics of Androgen Deficiency in Late-Onset Hypogonadism: Results from the European Male Aging Study (EMAS).},
  url          = {http://dx.doi.org/10.1210/jc.2011-2513},
  volume       = {97},
  year         = {2012},
}