Elevated urine levels of heparin-binding protein in children with urinary tract infection.
(2012) In Pediatric Nephrology 27(8). p.1301-1308- Abstract
- BACKGROUND: Urinary tract infection (UTI) is a common infection diagnosis in children, and efficient diagnosis and treatment are important to avoid serious complications. In this study we investigated whether urinary levels of neutrophil-derived heparin-binding protein (HBP) can be used as a marker of UTI in children. These results were compared to those of dipstick analysis, interleukin-6 (IL-6) analysis in urine, and bacterial culturing.
METHODS: Seventy-eight children aged 0-18 years with fever and/or symptoms indicating UTI were enrolled in a prospective consecutive study. Urine samples were cultured and analyzed with dipstick, and concentrations of HBP and IL-6 were measured.
RESULTS: Fifteen... (More) - BACKGROUND: Urinary tract infection (UTI) is a common infection diagnosis in children, and efficient diagnosis and treatment are important to avoid serious complications. In this study we investigated whether urinary levels of neutrophil-derived heparin-binding protein (HBP) can be used as a marker of UTI in children. These results were compared to those of dipstick analysis, interleukin-6 (IL-6) analysis in urine, and bacterial culturing.
METHODS: Seventy-eight children aged 0-18 years with fever and/or symptoms indicating UTI were enrolled in a prospective consecutive study. Urine samples were cultured and analyzed with dipstick, and concentrations of HBP and IL-6 were measured.
RESULTS: Fifteen patients were classified as having UTI, 30 patients had fever but were diagnosed with a non-urinary tract infection, and 33 patients had neither UTI nor fever. Using a urine HBP (U-HBP) cut-off level of 32 ng/mL, the sensitivity and specificity for detecting UTI were 93.3 and 90.3 %, respectively. Receiver operating characteristic curves demonstrated that U-HBP levels were a higher specificity indicator of UTI than urine white blood cell counts or urine IL-6 levels; they also showed a higher sensitivity than the results of the urine nitrite test. All patients with significant growth of clinically relevant bacteria had elevated U-HBP levels.
CONCLUSION: The results indicate that rapid analysis of U-HBP can provide helpful guidance in the management of children with suspected UTI. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2431910
- author
- Kjölvmark, Charlott LU ; Åkesson, Per LU and Linder, Adam LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Pediatric Nephrology
- volume
- 27
- issue
- 8
- pages
- 1301 - 1308
- publisher
- Springer
- external identifiers
-
- wos:000305682600011
- pmid:22410798
- scopus:84863980288
- pmid:22410798
- ISSN
- 1432-198X
- DOI
- 10.1007/s00467-012-2132-x
- language
- English
- LU publication?
- yes
- id
- 09a64086-0fa2-4536-a8f5-5ba9559e748f (old id 2431910)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22410798?dopt=Abstract
- date added to LUP
- 2016-04-04 09:27:20
- date last changed
- 2022-03-08 00:42:01
@article{09a64086-0fa2-4536-a8f5-5ba9559e748f,
abstract = {{BACKGROUND: Urinary tract infection (UTI) is a common infection diagnosis in children, and efficient diagnosis and treatment are important to avoid serious complications. In this study we investigated whether urinary levels of neutrophil-derived heparin-binding protein (HBP) can be used as a marker of UTI in children. These results were compared to those of dipstick analysis, interleukin-6 (IL-6) analysis in urine, and bacterial culturing. <br/><br>
<br/><br>
METHODS: Seventy-eight children aged 0-18 years with fever and/or symptoms indicating UTI were enrolled in a prospective consecutive study. Urine samples were cultured and analyzed with dipstick, and concentrations of HBP and IL-6 were measured. <br/><br>
<br/><br>
RESULTS: Fifteen patients were classified as having UTI, 30 patients had fever but were diagnosed with a non-urinary tract infection, and 33 patients had neither UTI nor fever. Using a urine HBP (U-HBP) cut-off level of 32 ng/mL, the sensitivity and specificity for detecting UTI were 93.3 and 90.3 %, respectively. Receiver operating characteristic curves demonstrated that U-HBP levels were a higher specificity indicator of UTI than urine white blood cell counts or urine IL-6 levels; they also showed a higher sensitivity than the results of the urine nitrite test. All patients with significant growth of clinically relevant bacteria had elevated U-HBP levels. <br/><br>
<br/><br>
CONCLUSION: The results indicate that rapid analysis of U-HBP can provide helpful guidance in the management of children with suspected UTI.}},
author = {{Kjölvmark, Charlott and Åkesson, Per and Linder, Adam}},
issn = {{1432-198X}},
language = {{eng}},
number = {{8}},
pages = {{1301--1308}},
publisher = {{Springer}},
series = {{Pediatric Nephrology}},
title = {{Elevated urine levels of heparin-binding protein in children with urinary tract infection.}},
url = {{http://dx.doi.org/10.1007/s00467-012-2132-x}},
doi = {{10.1007/s00467-012-2132-x}},
volume = {{27}},
year = {{2012}},
}