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Elevated urine levels of heparin-binding protein in children with urinary tract infection.

Kjölvmark, Charlott LU ; Åkesson, Per LU and Linder, Adam LU (2012) In Pediatric Nephrology 27(8). p.1301-1308
Abstract
BACKGROUND: Urinary tract infection (UTI) is a common infection diagnosis in children, and efficient diagnosis and treatment are important to avoid serious complications. In this study we investigated whether urinary levels of neutrophil-derived heparin-binding protein (HBP) can be used as a marker of UTI in children. These results were compared to those of dipstick analysis, interleukin-6 (IL-6) analysis in urine, and bacterial culturing.



METHODS: Seventy-eight children aged 0-18 years with fever and/or symptoms indicating UTI were enrolled in a prospective consecutive study. Urine samples were cultured and analyzed with dipstick, and concentrations of HBP and IL-6 were measured.



RESULTS: Fifteen... (More)
BACKGROUND: Urinary tract infection (UTI) is a common infection diagnosis in children, and efficient diagnosis and treatment are important to avoid serious complications. In this study we investigated whether urinary levels of neutrophil-derived heparin-binding protein (HBP) can be used as a marker of UTI in children. These results were compared to those of dipstick analysis, interleukin-6 (IL-6) analysis in urine, and bacterial culturing.



METHODS: Seventy-eight children aged 0-18 years with fever and/or symptoms indicating UTI were enrolled in a prospective consecutive study. Urine samples were cultured and analyzed with dipstick, and concentrations of HBP and IL-6 were measured.



RESULTS: Fifteen patients were classified as having UTI, 30 patients had fever but were diagnosed with a non-urinary tract infection, and 33 patients had neither UTI nor fever. Using a urine HBP (U-HBP) cut-off level of 32 ng/mL, the sensitivity and specificity for detecting UTI were 93.3 and 90.3 %, respectively. Receiver operating characteristic curves demonstrated that U-HBP levels were a higher specificity indicator of UTI than urine white blood cell counts or urine IL-6 levels; they also showed a higher sensitivity than the results of the urine nitrite test. All patients with significant growth of clinically relevant bacteria had elevated U-HBP levels.



CONCLUSION: The results indicate that rapid analysis of U-HBP can provide helpful guidance in the management of children with suspected UTI. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pediatric Nephrology
volume
27
issue
8
pages
1301 - 1308
publisher
Springer
external identifiers
  • WOS:000305682600011
  • PMID:22410798
  • Scopus:84863980288
ISSN
1432-198X
DOI
10.1007/s00467-012-2132-x
language
English
LU publication?
yes
id
09a64086-0fa2-4536-a8f5-5ba9559e748f (old id 2431910)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22410798?dopt=Abstract
date added to LUP
2012-04-03 10:41:30
date last changed
2017-01-01 07:49:12
@article{09a64086-0fa2-4536-a8f5-5ba9559e748f,
  abstract     = {BACKGROUND: Urinary tract infection (UTI) is a common infection diagnosis in children, and efficient diagnosis and treatment are important to avoid serious complications. In this study we investigated whether urinary levels of neutrophil-derived heparin-binding protein (HBP) can be used as a marker of UTI in children. These results were compared to those of dipstick analysis, interleukin-6 (IL-6) analysis in urine, and bacterial culturing. <br/><br>
<br/><br>
METHODS: Seventy-eight children aged 0-18 years with fever and/or symptoms indicating UTI were enrolled in a prospective consecutive study. Urine samples were cultured and analyzed with dipstick, and concentrations of HBP and IL-6 were measured. <br/><br>
<br/><br>
RESULTS: Fifteen patients were classified as having UTI, 30 patients had fever but were diagnosed with a non-urinary tract infection, and 33 patients had neither UTI nor fever. Using a urine HBP (U-HBP) cut-off level of 32 ng/mL, the sensitivity and specificity for detecting UTI were 93.3 and 90.3 %, respectively. Receiver operating characteristic curves demonstrated that U-HBP levels were a higher specificity indicator of UTI than urine white blood cell counts or urine IL-6 levels; they also showed a higher sensitivity than the results of the urine nitrite test. All patients with significant growth of clinically relevant bacteria had elevated U-HBP levels. <br/><br>
<br/><br>
CONCLUSION: The results indicate that rapid analysis of U-HBP can provide helpful guidance in the management of children with suspected UTI.},
  author       = {Kjölvmark, Charlott and Åkesson, Per and Linder, Adam},
  issn         = {1432-198X},
  language     = {eng},
  number       = {8},
  pages        = {1301--1308},
  publisher    = {Springer},
  series       = {Pediatric Nephrology},
  title        = {Elevated urine levels of heparin-binding protein in children with urinary tract infection.},
  url          = {http://dx.doi.org/10.1007/s00467-012-2132-x},
  volume       = {27},
  year         = {2012},
}