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Collagen VI Encodes Antimicrobial Activity: Novel Innate Host Defense Properties of the Extracellular Matrix.

M Abdillahi, Suado LU ; Balvanović, Selma; Baumgarten, Maria LU and Mörgelin, Matthias LU (2012) In Journal of Innate Immunity 4(4). p.371-376
Abstract
Collagen type VI is a subepithelial extracellular matrix component in airways and an adhesive substrate for oral pathogens [Bober et al.: J Innate Immun 2010;2:160-166]. Here, we report that collagen VI displays a dose-dependent antimicrobial activity against group A, C, and G streptococci by membrane disruption in physiological conditions. The data disclose previously unrecognized aspects of the extracellular matrix in innate host defense.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Innate Immunity
volume
4
issue
4
pages
371 - 376
publisher
Karger
external identifiers
  • wos:000305819800006
  • pmid:22398575
  • scopus:84863335308
ISSN
1662-811X
DOI
10.1159/000335239
language
English
LU publication?
yes
id
74c5e330-ab74-414e-9c9f-72ad97b15723 (old id 2432163)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22398575?dopt=Abstract
date added to LUP
2012-04-03 09:31:42
date last changed
2017-01-01 07:40:23
@article{74c5e330-ab74-414e-9c9f-72ad97b15723,
  abstract     = {Collagen type VI is a subepithelial extracellular matrix component in airways and an adhesive substrate for oral pathogens [Bober et al.: J Innate Immun 2010;2:160-166]. Here, we report that collagen VI displays a dose-dependent antimicrobial activity against group A, C, and G streptococci by membrane disruption in physiological conditions. The data disclose previously unrecognized aspects of the extracellular matrix in innate host defense.},
  author       = {M Abdillahi, Suado and Balvanović, Selma and Baumgarten, Maria and Mörgelin, Matthias},
  issn         = {1662-811X},
  language     = {eng},
  number       = {4},
  pages        = {371--376},
  publisher    = {Karger},
  series       = {Journal of Innate Immunity},
  title        = {Collagen VI Encodes Antimicrobial Activity: Novel Innate Host Defense Properties of the Extracellular Matrix.},
  url          = {http://dx.doi.org/10.1159/000335239},
  volume       = {4},
  year         = {2012},
}