Advanced

Smoking as a determinant for plasma levels of testosterone, androstenedione, and DHEAs in postmenopausal women

Manjer, Jonas LU ; Johansson, R and Lenner, P (2005) In European Journal of Epidemiology 20(4). p.331-337
Abstract
The aim of the present study was to investigate whether current smoking, ex-smoking, or amount of current smoking among postmenopausal women was associated with plasma levels of testosterone, and rostenedione, and DHEAs. About 65,000 women in Sweden have participated in two population-based prospective cohort studies where blood samples were collected at baseline, and information on life-style, reproductive history and anthropometrical measurements were available. The present study was based on 407 control subjects from a previous nested case-control study on the relation between steroid hormone levels and risk of breast cancer. A multivariate logistic regression analysis, adjusted for potential confounders, was used in order to obtain... (More)
The aim of the present study was to investigate whether current smoking, ex-smoking, or amount of current smoking among postmenopausal women was associated with plasma levels of testosterone, and rostenedione, and DHEAs. About 65,000 women in Sweden have participated in two population-based prospective cohort studies where blood samples were collected at baseline, and information on life-style, reproductive history and anthropometrical measurements were available. The present study was based on 407 control subjects from a previous nested case-control study on the relation between steroid hormone levels and risk of breast cancer. A multivariate logistic regression analysis, adjusted for potential confounders, was used in order to obtain odds ratios (OR) with 95 confidence intervals. There was a high risk of high testosterone levels (above the median) in current vs. never smokers, OR1.85 (1.06-3.23). Risk of high testosterone levels increased by amount of daily smoking (increments of 10 cigarettes/day), OR 1.55 (1.02-2.37). Ex-smoking was associated with high testosterone levels, OR: 1.56 (0.98-2.47). Current smoking and increasing amount of current smoking were weakly associated with high androstenedione levels. However, these associations did not reach statistical significance. No association was seen between smoking habits and DHEAs levels. We conclude that current smoking, and increasing amount of daily smoking, is associated with high testosterone levels. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
women, testosterone, smoking, androstenedione, DHEAs
in
European Journal of Epidemiology
volume
20
issue
4
pages
331 - 337
publisher
Springer
external identifiers
  • pmid:15971505
  • wos:000228877700007
  • scopus:18844421650
ISSN
1573-7284
DOI
10.1007/s10654-005-0385-4
language
English
LU publication?
yes
id
b417d893-90ce-4e38-b430-2e8814fbe64b (old id 243755)
date added to LUP
2007-10-05 08:52:44
date last changed
2017-08-06 03:33:43
@article{b417d893-90ce-4e38-b430-2e8814fbe64b,
  abstract     = {The aim of the present study was to investigate whether current smoking, ex-smoking, or amount of current smoking among postmenopausal women was associated with plasma levels of testosterone, and rostenedione, and DHEAs. About 65,000 women in Sweden have participated in two population-based prospective cohort studies where blood samples were collected at baseline, and information on life-style, reproductive history and anthropometrical measurements were available. The present study was based on 407 control subjects from a previous nested case-control study on the relation between steroid hormone levels and risk of breast cancer. A multivariate logistic regression analysis, adjusted for potential confounders, was used in order to obtain odds ratios (OR) with 95 confidence intervals. There was a high risk of high testosterone levels (above the median) in current vs. never smokers, OR1.85 (1.06-3.23). Risk of high testosterone levels increased by amount of daily smoking (increments of 10 cigarettes/day), OR 1.55 (1.02-2.37). Ex-smoking was associated with high testosterone levels, OR: 1.56 (0.98-2.47). Current smoking and increasing amount of current smoking were weakly associated with high androstenedione levels. However, these associations did not reach statistical significance. No association was seen between smoking habits and DHEAs levels. We conclude that current smoking, and increasing amount of daily smoking, is associated with high testosterone levels.},
  author       = {Manjer, Jonas and Johansson, R and Lenner, P},
  issn         = {1573-7284},
  keyword      = {women,testosterone,smoking,androstenedione,DHEAs},
  language     = {eng},
  number       = {4},
  pages        = {331--337},
  publisher    = {Springer},
  series       = {European Journal of Epidemiology},
  title        = {Smoking as a determinant for plasma levels of testosterone, androstenedione, and DHEAs in postmenopausal women},
  url          = {http://dx.doi.org/10.1007/s10654-005-0385-4},
  volume       = {20},
  year         = {2005},
}