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Development of a new patient-reported outcome measure for Dupuytren disease : A study protocol

Eckerdal, David LU ; Lyrén, Per Erik ; McEachan, Jane ; Lauritzson, Anna ; Nordenskjöld, Jesper LU and Atroshi, Isam LU (2024) In Health Informatics Journal 30(4).
Abstract

Objectives: Dupuytren disease is a common condition that causes progressive finger contractures resulting in impaired hand function and difficulties in performing daily activities. Patient reported outcome measures (PROMs) are commonly used in research and clinical practice to evaluate treatment outcomes. Both general upper extremity PROMs and Dupuytren-specific PROMs are available, typically developed using conventional methodology based on classical test theory. However, most current PROMs have been shown to have low responsiveness and the relevance of included items have been questioned. In this study we aim to develop a new Dupuytren-specific PROM using modern measurement methodology based on item response theory (IRT). Methods: The... (More)

Objectives: Dupuytren disease is a common condition that causes progressive finger contractures resulting in impaired hand function and difficulties in performing daily activities. Patient reported outcome measures (PROMs) are commonly used in research and clinical practice to evaluate treatment outcomes. Both general upper extremity PROMs and Dupuytren-specific PROMs are available, typically developed using conventional methodology based on classical test theory. However, most current PROMs have been shown to have low responsiveness and the relevance of included items have been questioned. In this study we aim to develop a new Dupuytren-specific PROM using modern measurement methodology based on item response theory (IRT). Methods: The study will be performed in three phases. In Phase 1, (completed), an expert group developed a questionnaire with a large number of potentially relevant items derived from existing PROMs and patient collaboration. In Phase 2, the questionnaire will be administered to 300 patients with Dupuytren disease, and their responses will be analyzed with IRT methodology to identify the best performing items to be included in the new PROM. In Phase 3, the new PROM will be administered to 300 additional patients for validation. Conclusion: This new Dupuytren-specific patient-reported outcome measure will help advance clinical research on Dupuytren disease.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
dupuytren, hand, item response theory, outcome measure, PROM
in
Health Informatics Journal
volume
30
issue
4
publisher
SAGE Publications
external identifiers
  • scopus:85209701733
  • pmid:39547239
ISSN
1460-4582
DOI
10.1177/14604582241301642
language
English
LU publication?
yes
id
24427017-9a63-4c1b-bb5e-d9e7af7cd02b
date added to LUP
2025-01-15 13:23:06
date last changed
2025-07-17 04:29:26
@article{24427017-9a63-4c1b-bb5e-d9e7af7cd02b,
  abstract     = {{<p>Objectives: Dupuytren disease is a common condition that causes progressive finger contractures resulting in impaired hand function and difficulties in performing daily activities. Patient reported outcome measures (PROMs) are commonly used in research and clinical practice to evaluate treatment outcomes. Both general upper extremity PROMs and Dupuytren-specific PROMs are available, typically developed using conventional methodology based on classical test theory. However, most current PROMs have been shown to have low responsiveness and the relevance of included items have been questioned. In this study we aim to develop a new Dupuytren-specific PROM using modern measurement methodology based on item response theory (IRT). Methods: The study will be performed in three phases. In Phase 1, (completed), an expert group developed a questionnaire with a large number of potentially relevant items derived from existing PROMs and patient collaboration. In Phase 2, the questionnaire will be administered to 300 patients with Dupuytren disease, and their responses will be analyzed with IRT methodology to identify the best performing items to be included in the new PROM. In Phase 3, the new PROM will be administered to 300 additional patients for validation. Conclusion: This new Dupuytren-specific patient-reported outcome measure will help advance clinical research on Dupuytren disease.</p>}},
  author       = {{Eckerdal, David and Lyrén, Per Erik and McEachan, Jane and Lauritzson, Anna and Nordenskjöld, Jesper and Atroshi, Isam}},
  issn         = {{1460-4582}},
  keywords     = {{dupuytren; hand; item response theory; outcome measure; PROM}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{4}},
  publisher    = {{SAGE Publications}},
  series       = {{Health Informatics Journal}},
  title        = {{Development of a new patient-reported outcome measure for Dupuytren disease : A study protocol}},
  url          = {{http://dx.doi.org/10.1177/14604582241301642}},
  doi          = {{10.1177/14604582241301642}},
  volume       = {{30}},
  year         = {{2024}},
}