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Ocular vasodynamic changes in light and darkness in smokers

Havelius, Ulf LU and Hansen, F (2005) In Investigative Ophthalmology & Visual Science 46(5). p.1698-1705
Abstract
PURPOSE. To determine whether smokers have a reduced capacity for increased retinal blood flow velocity in darkness. METHODS. The peak systolic flow velocities (V-S) and end diastolic flow velocities (V-D) were measured by ultrasound ( i.e., color Doppler equipment), in light and darkness in the ophthalmic and central retinal arteries in 20 cigarette smokers and 20 matched nonsmokers. The resistive index ( RI) was calculated as RI = (V-S - V-D)/V-S. RESULTS. In the ophthalmic artery in nonsmokers, the V-D was markedly increased in darkness and the RI was correspondingly reduced. After the subject was re-exposed to light, the RI was markedly increased. In smokers the V-S and V-D did not change significantly in the different conditions of... (More)
PURPOSE. To determine whether smokers have a reduced capacity for increased retinal blood flow velocity in darkness. METHODS. The peak systolic flow velocities (V-S) and end diastolic flow velocities (V-D) were measured by ultrasound ( i.e., color Doppler equipment), in light and darkness in the ophthalmic and central retinal arteries in 20 cigarette smokers and 20 matched nonsmokers. The resistive index ( RI) was calculated as RI = (V-S - V-D)/V-S. RESULTS. In the ophthalmic artery in nonsmokers, the V-D was markedly increased in darkness and the RI was correspondingly reduced. After the subject was re-exposed to light, the RI was markedly increased. In smokers the V-S and V-D did not change significantly in the different conditions of light and darkness. In the central retinal artery in nonsmokers, the V-S and V-D were markedly increased in darkness and decreased after re-exposure to light. In smokers, the corresponding changes were much smaller and not significant. CONCLUSIONS. The normal capacity for increased blood flow velocity in the central retinal artery in darkness was markedly reduced in smokers. This finding may explain the reduced dark vision after recent smoking reported in several studies and probably reflects the combined effects of an increased blood viscosity, the vasoconstrictive action of nicotine, and a reduced capacity of the blood to transport oxygen, as the hemoglobin is partly occupied by carbon monoxide. (Less)
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type
Contribution to journal
publication status
published
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in
Investigative Ophthalmology & Visual Science
volume
46
issue
5
pages
1698 - 1705
publisher
Association for Research in Vision and Ophthalmology Inc.
external identifiers
  • pmid:15851571
  • wos:000228708000025
  • scopus:20444471915
  • pmid:15851571
ISSN
1552-5783
DOI
10.1167/iovs.04-0756
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Ophthalmology (Lund) (013043000), Clinical Physiology (013242300), Ophthalmology (013242810)
id
fc41bd50-c10f-4cd3-8941-5255ca0d5489 (old id 244435)
date added to LUP
2016-04-01 16:44:08
date last changed
2021-02-17 04:18:54
@article{fc41bd50-c10f-4cd3-8941-5255ca0d5489,
  abstract     = {PURPOSE. To determine whether smokers have a reduced capacity for increased retinal blood flow velocity in darkness. METHODS. The peak systolic flow velocities (V-S) and end diastolic flow velocities (V-D) were measured by ultrasound ( i.e., color Doppler equipment), in light and darkness in the ophthalmic and central retinal arteries in 20 cigarette smokers and 20 matched nonsmokers. The resistive index ( RI) was calculated as RI = (V-S - V-D)/V-S. RESULTS. In the ophthalmic artery in nonsmokers, the V-D was markedly increased in darkness and the RI was correspondingly reduced. After the subject was re-exposed to light, the RI was markedly increased. In smokers the V-S and V-D did not change significantly in the different conditions of light and darkness. In the central retinal artery in nonsmokers, the V-S and V-D were markedly increased in darkness and decreased after re-exposure to light. In smokers, the corresponding changes were much smaller and not significant. CONCLUSIONS. The normal capacity for increased blood flow velocity in the central retinal artery in darkness was markedly reduced in smokers. This finding may explain the reduced dark vision after recent smoking reported in several studies and probably reflects the combined effects of an increased blood viscosity, the vasoconstrictive action of nicotine, and a reduced capacity of the blood to transport oxygen, as the hemoglobin is partly occupied by carbon monoxide.},
  author       = {Havelius, Ulf and Hansen, F},
  issn         = {1552-5783},
  language     = {eng},
  number       = {5},
  pages        = {1698--1705},
  publisher    = {Association for Research in Vision and Ophthalmology Inc.},
  series       = {Investigative Ophthalmology & Visual Science},
  title        = {Ocular vasodynamic changes in light and darkness in smokers},
  url          = {http://dx.doi.org/10.1167/iovs.04-0756},
  doi          = {10.1167/iovs.04-0756},
  volume       = {46},
  year         = {2005},
}