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Indentation testing of a bone defect filled with two different injectable bone substitutes

Wang, Jian-Sheng LU ; Tanner, KE ; Abdulghani, Saba LU and Lidgren, Lars LU (2005) In Key Engineering Materials 284-286. p.89-92
Abstract
Injectable bone substitutes (IBS) based on calcium phosphate (CaP) and/or calcium sulphate (CaS) are used as fillers in bone defects to stimulate bone integration and allow mechanical loading. Two types of IBS, IBS-1 is CaP+20%CaS and IBS-2 is CaS+40% hydroxyapatite, were investigated. The materials were injected into holes in the femur and tibia in rabbits. After 10 weeks the femora were subjected to indentation testing and tibiae were prepared for histology evaluation. IBS-1 lead to an higher indentation load compared to control, that is no material inserted, while IBS-2 showed no significant difference between material and control. Histology showed that with IBS-1, the bone penetrated into and integrated with the material in the defect.... (More)
Injectable bone substitutes (IBS) based on calcium phosphate (CaP) and/or calcium sulphate (CaS) are used as fillers in bone defects to stimulate bone integration and allow mechanical loading. Two types of IBS, IBS-1 is CaP+20%CaS and IBS-2 is CaS+40% hydroxyapatite, were investigated. The materials were injected into holes in the femur and tibia in rabbits. After 10 weeks the femora were subjected to indentation testing and tibiae were prepared for histology evaluation. IBS-1 lead to an higher indentation load compared to control, that is no material inserted, while IBS-2 showed no significant difference between material and control. Histology showed that with IBS-1, the bone penetrated into and integrated with the material in the defect. With IBS-2, new bone grew into the outer 0.5-1.0 mm. The materials could be used for different indications, such as to support fracture healing or in contained cavities. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
test, indentation, calcium sulphate, bone defect model, calcium phosphate, injectable bone substitute
in
Key Engineering Materials
volume
284-286
pages
89 - 92
publisher
Trans Tech Publications Ltd
external identifiers
  • wos:000228359500022
  • scopus:34248994283
ISSN
1013-9826
language
English
LU publication?
yes
id
15588d0d-d3a0-4d24-9b95-9f37a4fe0d75 (old id 244563)
date added to LUP
2016-04-01 16:52:43
date last changed
2025-04-04 14:14:02
@article{15588d0d-d3a0-4d24-9b95-9f37a4fe0d75,
  abstract     = {{Injectable bone substitutes (IBS) based on calcium phosphate (CaP) and/or calcium sulphate (CaS) are used as fillers in bone defects to stimulate bone integration and allow mechanical loading. Two types of IBS, IBS-1 is CaP+20%CaS and IBS-2 is CaS+40% hydroxyapatite, were investigated. The materials were injected into holes in the femur and tibia in rabbits. After 10 weeks the femora were subjected to indentation testing and tibiae were prepared for histology evaluation. IBS-1 lead to an higher indentation load compared to control, that is no material inserted, while IBS-2 showed no significant difference between material and control. Histology showed that with IBS-1, the bone penetrated into and integrated with the material in the defect. With IBS-2, new bone grew into the outer 0.5-1.0 mm. The materials could be used for different indications, such as to support fracture healing or in contained cavities.}},
  author       = {{Wang, Jian-Sheng and Tanner, KE and Abdulghani, Saba and Lidgren, Lars}},
  issn         = {{1013-9826}},
  keywords     = {{test; indentation; calcium sulphate; bone defect model; calcium phosphate; injectable bone substitute}},
  language     = {{eng}},
  pages        = {{89--92}},
  publisher    = {{Trans Tech Publications Ltd}},
  series       = {{Key Engineering Materials}},
  title        = {{Indentation testing of a bone defect filled with two different injectable bone substitutes}},
  volume       = {{284-286}},
  year         = {{2005}},
}