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Loss of alpha 10 beta 1 integrin expression leads to moderate dysfunction of growth plate chondrocytes

Bengtsson, T; Aszodi, A; Nicolae, C; Hunziker, EB; Lundgren-Akerlund, E and Fässler, Reinhard LU (2005) In Journal of Cell Science 118(5). p.929-936
Abstract
Integrin alpha 10 beta 1 is a collagen-binding integrin expressed on chondrocytes. In order to unravel the role of the alpha 10 integrin during development, we generated mice carrying a constitutive deletion of the alpha 10 integrin gene. The mutant mice had a normal lifespan and were fertile but developed a growth retardation of the long bones. Analysis of the skeleton revealed defects in the growth plate after birth characterized by a disturbed columnar arrangement of chondrocytes, abnormal chondrocyte shape and reduced chondrocyte proliferation. Electron microscopy of growth plates from newborn mice revealed an increased number of apoptotic chondrocytes and reduced density of the collagen fibrillar network compared to these structures... (More)
Integrin alpha 10 beta 1 is a collagen-binding integrin expressed on chondrocytes. In order to unravel the role of the alpha 10 integrin during development, we generated mice carrying a constitutive deletion of the alpha 10 integrin gene. The mutant mice had a normal lifespan and were fertile but developed a growth retardation of the long bones. Analysis of the skeleton revealed defects in the growth plate after birth characterized by a disturbed columnar arrangement of chondrocytes, abnormal chondrocyte shape and reduced chondrocyte proliferation. Electron microscopy of growth plates from newborn mice revealed an increased number of apoptotic chondrocytes and reduced density of the collagen fibrillar network compared to these structures in control mice. These results demonstrate that integrin alpha 10 beta 1 plays a specific role in growth plate morphogenesis and function. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cartilage, proliferation, growth plate, integrin, knockout
in
Journal of Cell Science
volume
118
issue
5
pages
929 - 936
publisher
The Company of Biologists Ltd
external identifiers
  • pmid:15713743
  • wos:000228378400009
  • scopus:17044396261
ISSN
0021-9533
DOI
10.1242/jcs.01678
language
English
LU publication?
yes
id
ced7a406-ab1e-456d-8ec5-5007519975b1 (old id 246486)
date added to LUP
2007-08-16 11:42:21
date last changed
2017-10-01 03:38:22
@article{ced7a406-ab1e-456d-8ec5-5007519975b1,
  abstract     = {Integrin alpha 10 beta 1 is a collagen-binding integrin expressed on chondrocytes. In order to unravel the role of the alpha 10 integrin during development, we generated mice carrying a constitutive deletion of the alpha 10 integrin gene. The mutant mice had a normal lifespan and were fertile but developed a growth retardation of the long bones. Analysis of the skeleton revealed defects in the growth plate after birth characterized by a disturbed columnar arrangement of chondrocytes, abnormal chondrocyte shape and reduced chondrocyte proliferation. Electron microscopy of growth plates from newborn mice revealed an increased number of apoptotic chondrocytes and reduced density of the collagen fibrillar network compared to these structures in control mice. These results demonstrate that integrin alpha 10 beta 1 plays a specific role in growth plate morphogenesis and function.},
  author       = {Bengtsson, T and Aszodi, A and Nicolae, C and Hunziker, EB and Lundgren-Akerlund, E and Fässler, Reinhard},
  issn         = {0021-9533},
  keyword      = {cartilage,proliferation,growth plate,integrin,knockout},
  language     = {eng},
  number       = {5},
  pages        = {929--936},
  publisher    = {The Company of Biologists Ltd},
  series       = {Journal of Cell Science},
  title        = {Loss of alpha 10 beta 1 integrin expression leads to moderate dysfunction of growth plate chondrocytes},
  url          = {http://dx.doi.org/10.1242/jcs.01678},
  volume       = {118},
  year         = {2005},
}