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Cathelicidins - Nature's attempt at combinatorial chemistry

Sørensen, Ole E LU and Borregaard, N (2005) In Combinatorial Chemistry & High Throughput Screening 8(3). p.273-280
Abstract
Cathelicidins are a family of diverse antimicrobial peptides found in granules of mammalian neutrophils. Cathelicidins are active against a broad range of microbes in different environments. Aside from their antimicrobial activity, cathelicidins possess other biological properties including cytotoxic activity towards mammalian cells. Several studies have shown that the amino acid sequence of cathelicidins can be modified to temper undesired properties, such as hemolytic and cytotoxic activity, and at the same time maintain antimicrobial activity. These properties make cathelicidins ideal templates in combinatorial chemistry for designing de novo antimicrobial peptides for therapeutic use. However, one of the major challenges will be to... (More)
Cathelicidins are a family of diverse antimicrobial peptides found in granules of mammalian neutrophils. Cathelicidins are active against a broad range of microbes in different environments. Aside from their antimicrobial activity, cathelicidins possess other biological properties including cytotoxic activity towards mammalian cells. Several studies have shown that the amino acid sequence of cathelicidins can be modified to temper undesired properties, such as hemolytic and cytotoxic activity, and at the same time maintain antimicrobial activity. These properties make cathelicidins ideal templates in combinatorial chemistry for designing de novo antimicrobial peptides for therapeutic use. However, one of the major challenges will be to screen these peptides in experimentally relevant models that reflect the environments in which the peptides should be therapeutically active. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Combinatorial Chemistry & High Throughput Screening
volume
8
issue
3
pages
273 - 280
publisher
Bentham Science Publishers
external identifiers
  • pmid:15892628
  • wos:000228149700007
  • scopus:16844384573
ISSN
1386-2073
DOI
10.2174/1386207053764602
language
English
LU publication?
yes
id
3f82db0b-7fb5-4101-9226-b186f94f1fc7 (old id 246742)
date added to LUP
2007-08-08 09:20:59
date last changed
2017-01-01 04:33:17
@article{3f82db0b-7fb5-4101-9226-b186f94f1fc7,
  abstract     = {Cathelicidins are a family of diverse antimicrobial peptides found in granules of mammalian neutrophils. Cathelicidins are active against a broad range of microbes in different environments. Aside from their antimicrobial activity, cathelicidins possess other biological properties including cytotoxic activity towards mammalian cells. Several studies have shown that the amino acid sequence of cathelicidins can be modified to temper undesired properties, such as hemolytic and cytotoxic activity, and at the same time maintain antimicrobial activity. These properties make cathelicidins ideal templates in combinatorial chemistry for designing de novo antimicrobial peptides for therapeutic use. However, one of the major challenges will be to screen these peptides in experimentally relevant models that reflect the environments in which the peptides should be therapeutically active.},
  author       = {Sørensen, Ole E and Borregaard, N},
  issn         = {1386-2073},
  language     = {eng},
  number       = {3},
  pages        = {273--280},
  publisher    = {Bentham Science Publishers},
  series       = {Combinatorial Chemistry & High Throughput Screening},
  title        = {Cathelicidins - Nature's attempt at combinatorial chemistry},
  url          = {http://dx.doi.org/10.2174/1386207053764602},
  volume       = {8},
  year         = {2005},
}