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Anatomical and physiological foundations of cerebellar information processing

Apps, R and Garwicz, Martin LU (2005) In Nature Reviews Neuroscience 6(4). p.297-311
Abstract
A coordinated movement is easy to recognize, but we know little about how it is achieved. In search of the neural basis of coordination, we present a model of spinocerebellar interactions in which the structure-functional organizing principle is a division of the cerebellum into discrete microcomplexes. Each microcomplex is the recipient of a specific motor error signal-that is, a signal that conveys information about an inappropriate movement. These signals are encoded by spinal reflex circuits and conveyed to the cerebellar cortex through climbing fibre afferents. This organization reveals salient features of cerebellar information processing, but also highlights the importance of systems level analysis for a fuller understanding of the... (More)
A coordinated movement is easy to recognize, but we know little about how it is achieved. In search of the neural basis of coordination, we present a model of spinocerebellar interactions in which the structure-functional organizing principle is a division of the cerebellum into discrete microcomplexes. Each microcomplex is the recipient of a specific motor error signal-that is, a signal that conveys information about an inappropriate movement. These signals are encoded by spinal reflex circuits and conveyed to the cerebellar cortex through climbing fibre afferents. This organization reveals salient features of cerebellar information processing, but also highlights the importance of systems level analysis for a fuller understanding of the neural mechanisms that underlie behaviour. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Reviews Neuroscience
volume
6
issue
4
pages
297 - 311
publisher
Nature Publishing Group
external identifiers
  • pmid:15803161
  • wos:000228092300013
  • scopus:16344376363
ISSN
1471-003X
DOI
10.1038/nrn1646
language
English
LU publication?
yes
id
42f6fbf7-941e-4d57-8bf1-de09778527f6 (old id 247022)
date added to LUP
2007-08-02 11:21:45
date last changed
2017-11-19 04:08:17
@article{42f6fbf7-941e-4d57-8bf1-de09778527f6,
  abstract     = {A coordinated movement is easy to recognize, but we know little about how it is achieved. In search of the neural basis of coordination, we present a model of spinocerebellar interactions in which the structure-functional organizing principle is a division of the cerebellum into discrete microcomplexes. Each microcomplex is the recipient of a specific motor error signal-that is, a signal that conveys information about an inappropriate movement. These signals are encoded by spinal reflex circuits and conveyed to the cerebellar cortex through climbing fibre afferents. This organization reveals salient features of cerebellar information processing, but also highlights the importance of systems level analysis for a fuller understanding of the neural mechanisms that underlie behaviour.},
  author       = {Apps, R and Garwicz, Martin},
  issn         = {1471-003X},
  language     = {eng},
  number       = {4},
  pages        = {297--311},
  publisher    = {Nature Publishing Group},
  series       = {Nature Reviews Neuroscience},
  title        = {Anatomical and physiological foundations of cerebellar information processing},
  url          = {http://dx.doi.org/10.1038/nrn1646},
  volume       = {6},
  year         = {2005},
}