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European multi-centre case-control study on risk factors for rare cancers of unknown aetiology

Lynge, E; Afonso, N; Kaerlev, L; Olsen, J; Sabroe, S; Ahrens, W; Eriksson, Mikael LU ; Guenel, P; Merletti, F and Stengrevics, A, et al. (2005) In European Journal of Cancer 41(4). p.601-612
Abstract
To search for occupational risk factors, we conducted a case-control study in nine European countries of cancers of the small intestine, male gall bladder, thymus, bone, male breast, melanoma of the eye, and mycosis fungoides. Recruitment was population based in Denmark, Latvia, France, Germany, Italy, and Sweden, from hospital areas in Spain and Portugal, and from one United Kingdom (UK) hospital. We recruited 1457 cases (84% interviewed). Numbers identified corresponded to those in the EUROCIM database for Denmark, but were below those observed for France, Italy and Sweden in the database. We recruited 3374 population (61% interviewed) and 1284 colon cancer controls (86% interviewed). It was possible to undertake this complicated study... (More)
To search for occupational risk factors, we conducted a case-control study in nine European countries of cancers of the small intestine, male gall bladder, thymus, bone, male breast, melanoma of the eye, and mycosis fungoides. Recruitment was population based in Denmark, Latvia, France, Germany, Italy, and Sweden, from hospital areas in Spain and Portugal, and from one United Kingdom (UK) hospital. We recruited 1457 cases (84% interviewed). Numbers identified corresponded to those in the EUROCIM database for Denmark, but were below those observed for France, Italy and Sweden in the database. We recruited 3374 population (61% interviewed) and 1284 colon cancer controls (86% interviewed). It was possible to undertake this complicated study across Europe, but we encountered three main problems. It was difficult to ensure complete case ascertainment, for population controls, we found a clear divide in the response rate from 75% in the South to only 55% in the North, and a somewhat selective recruitment was noted for the colon cancer controls. The study showed there is a clear dose-response relationship between alcohol intake and the risk of male breast cancer, and an excess risk of mycosis fungoides among glass formers, pottery and ceramic workers. Further data are expected. (Less)
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Contribution to journal
publication status
published
subject
keywords
multi-centric case-control study, methods, occupational risk factors, case-control study, rare cancer
in
European Journal of Cancer
volume
41
issue
4
pages
601 - 612
publisher
IFAC & Elsevier Ltd.
external identifiers
  • wos:000227937800026
  • pmid:15737566
  • scopus:20044388118
ISSN
1879-0852
DOI
10.1016/j.ejca.2004.12.016
language
English
LU publication?
yes
id
85214da7-057e-4125-bc82-83b84fa5f01c (old id 247123)
date added to LUP
2007-08-10 14:53:07
date last changed
2017-08-27 03:56:17
@article{85214da7-057e-4125-bc82-83b84fa5f01c,
  abstract     = {To search for occupational risk factors, we conducted a case-control study in nine European countries of cancers of the small intestine, male gall bladder, thymus, bone, male breast, melanoma of the eye, and mycosis fungoides. Recruitment was population based in Denmark, Latvia, France, Germany, Italy, and Sweden, from hospital areas in Spain and Portugal, and from one United Kingdom (UK) hospital. We recruited 1457 cases (84% interviewed). Numbers identified corresponded to those in the EUROCIM database for Denmark, but were below those observed for France, Italy and Sweden in the database. We recruited 3374 population (61% interviewed) and 1284 colon cancer controls (86% interviewed). It was possible to undertake this complicated study across Europe, but we encountered three main problems. It was difficult to ensure complete case ascertainment, for population controls, we found a clear divide in the response rate from 75% in the South to only 55% in the North, and a somewhat selective recruitment was noted for the colon cancer controls. The study showed there is a clear dose-response relationship between alcohol intake and the risk of male breast cancer, and an excess risk of mycosis fungoides among glass formers, pottery and ceramic workers. Further data are expected.},
  author       = {Lynge, E and Afonso, N and Kaerlev, L and Olsen, J and Sabroe, S and Ahrens, W and Eriksson, Mikael and Guenel, P and Merletti, F and Stengrevics, A and Suarez-Varela, M and Costa-Pererra, A and Vyberg, M},
  issn         = {1879-0852},
  keyword      = {multi-centric case-control study,methods,occupational risk factors,case-control study,rare cancer},
  language     = {eng},
  number       = {4},
  pages        = {601--612},
  publisher    = {IFAC & Elsevier Ltd.},
  series       = {European Journal of Cancer},
  title        = {European multi-centre case-control study on risk factors for rare cancers of unknown aetiology},
  url          = {http://dx.doi.org/10.1016/j.ejca.2004.12.016},
  volume       = {41},
  year         = {2005},
}