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High plasma concentrations of autoantibodies against native peptide 210 of apoB-100 are related to less coronary atherosclerosis and lower risk of myocardial infarction

Sjogren, Per ; Nordin Fredrikson, Gunilla LU ; Samnegard, Ann ; Ericsson, Carl-Goran ; Ohrvik, John ; Fisher, Rachel M. ; Nilsson, Jan LU and Hamsten, Anders (2008) In European Heart Journal 29(18). p.2218-2226
Abstract
Aims We examined whether antibodies against peptides 45 and 210 of apoB-100 are related to myocardial infarction (MI) and severity of coronary atherosclerosis. Methods and results Three hundred and eighty-seven survivors of a first MI (aged < 60 years) and 387 sex- and age-matched controls were characterized in detail. IgG and IgM autoantibodies against native and malondialdehyde (MDA)-modified peptides 45 and 210 of apoB-100 (amino acids 661-680 and 3136-3155) were quantified in plasma and quantitative coronary angiography was performed in 243 patients. Post-infarction patients had significantly lower IgG against the native peptide 210 (IgG-p210(nat)) and higher IgM against the MDA-modified peptide 210 (IgM-p210(MDA)) compared with... (More)
Aims We examined whether antibodies against peptides 45 and 210 of apoB-100 are related to myocardial infarction (MI) and severity of coronary atherosclerosis. Methods and results Three hundred and eighty-seven survivors of a first MI (aged < 60 years) and 387 sex- and age-matched controls were characterized in detail. IgG and IgM autoantibodies against native and malondialdehyde (MDA)-modified peptides 45 and 210 of apoB-100 (amino acids 661-680 and 3136-3155) were quantified in plasma and quantitative coronary angiography was performed in 243 patients. Post-infarction patients had significantly lower IgG against the native peptide 210 (IgG-p210(nat)) and higher IgM against the MDA-modified peptide 210 (IgM-p210(MDA)) compared with controls, whereas no differences were found for other antibodies. Plasma concentrations of IgG-p210(nat), but not IgM-p210(MDA), were independently and inversely related to the degree of coronary atherosclerosis in patients. In multiple logistic regression analysis (including established risk indicators), MI risk was 0.55 (95%CI: 0.37-0.81) for individuals in the IgG-p210(nat) upper quartile compared with the remaining individuals. Conclusion Circulating IgG antibodies against the native peptide 210 of apoB-100 are inversely related to the severity of coronary atherosclerosis and associated with lower risk of MI. Epitope 210 of apoB-100 emerges as a target for immunization against atherosclerosis in humans. (Less)
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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
coronary atherosclerosis, myocardial infarction, oxidized, angiography, LDL, autoantibodies, apoB-100
in
European Heart Journal
volume
29
issue
18
pages
2218 - 2226
publisher
Oxford University Press
external identifiers
  • wos:000259327000008
  • scopus:52449095211
ISSN
1522-9645
DOI
10.1093/eurheartj/ehn336
language
English
LU publication?
yes
id
24784ba5-6767-43a7-8052-6fb1177c03db (old id 1246986)
date added to LUP
2016-04-01 14:56:15
date last changed
2022-02-27 05:14:11
@article{24784ba5-6767-43a7-8052-6fb1177c03db,
  abstract     = {{Aims We examined whether antibodies against peptides 45 and 210 of apoB-100 are related to myocardial infarction (MI) and severity of coronary atherosclerosis. Methods and results Three hundred and eighty-seven survivors of a first MI (aged &lt; 60 years) and 387 sex- and age-matched controls were characterized in detail. IgG and IgM autoantibodies against native and malondialdehyde (MDA)-modified peptides 45 and 210 of apoB-100 (amino acids 661-680 and 3136-3155) were quantified in plasma and quantitative coronary angiography was performed in 243 patients. Post-infarction patients had significantly lower IgG against the native peptide 210 (IgG-p210(nat)) and higher IgM against the MDA-modified peptide 210 (IgM-p210(MDA)) compared with controls, whereas no differences were found for other antibodies. Plasma concentrations of IgG-p210(nat), but not IgM-p210(MDA), were independently and inversely related to the degree of coronary atherosclerosis in patients. In multiple logistic regression analysis (including established risk indicators), MI risk was 0.55 (95%CI: 0.37-0.81) for individuals in the IgG-p210(nat) upper quartile compared with the remaining individuals. Conclusion Circulating IgG antibodies against the native peptide 210 of apoB-100 are inversely related to the severity of coronary atherosclerosis and associated with lower risk of MI. Epitope 210 of apoB-100 emerges as a target for immunization against atherosclerosis in humans.}},
  author       = {{Sjogren, Per and Nordin Fredrikson, Gunilla and Samnegard, Ann and Ericsson, Carl-Goran and Ohrvik, John and Fisher, Rachel M. and Nilsson, Jan and Hamsten, Anders}},
  issn         = {{1522-9645}},
  keywords     = {{coronary atherosclerosis; myocardial infarction; oxidized; angiography; LDL; autoantibodies; apoB-100}},
  language     = {{eng}},
  number       = {{18}},
  pages        = {{2218--2226}},
  publisher    = {{Oxford University Press}},
  series       = {{European Heart Journal}},
  title        = {{High plasma concentrations of autoantibodies against native peptide 210 of apoB-100 are related to less coronary atherosclerosis and lower risk of myocardial infarction}},
  url          = {{http://dx.doi.org/10.1093/eurheartj/ehn336}},
  doi          = {{10.1093/eurheartj/ehn336}},
  volume       = {{29}},
  year         = {{2008}},
}