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The ribosome story: An overview of structural studies of protein synthesis on the ribosome

Liljas, Anders LU (2011) In Crystallography Reviews 17(3). p.205-223
Abstract
Protein synthesis has been studied for more than half a century, but the atomic details of this complex system, the ribosome, began to be revealed in 1999 and 2000 through crystallographic structure determinations. As with all biomolecular systems, the advent of atomic structures are milestones in the process of relating function to structure. During these 10 years there has been an avalanche in biochemical investigations related to the crystal structures as well as new structures pinpointing specific functional details. Three of the central workers in the field (Venkatraman Ramakrishnan, Thomas Steitz and Ada Yonath) were awarded the Nobel Prize for Chemistry 2009. Even though their work has led to significant leaps in understanding, much... (More)
Protein synthesis has been studied for more than half a century, but the atomic details of this complex system, the ribosome, began to be revealed in 1999 and 2000 through crystallographic structure determinations. As with all biomolecular systems, the advent of atomic structures are milestones in the process of relating function to structure. During these 10 years there has been an avalanche in biochemical investigations related to the crystal structures as well as new structures pinpointing specific functional details. Three of the central workers in the field (Venkatraman Ramakrishnan, Thomas Steitz and Ada Yonath) were awarded the Nobel Prize for Chemistry 2009. Even though their work has led to significant leaps in understanding, much remains to be clarified. This review will summarize some of the work so far and the understanding achieved. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
GTP, hydrolysis, elongation factors, ribosome, peptidyl transfer, translation
in
Crystallography Reviews
volume
17
issue
3
pages
205 - 223
publisher
Taylor & Francis
external identifiers
  • wos:000299435700004
  • scopus:79960405114
ISSN
0889-311X
DOI
10.1080/0889311X.2011.587812
language
English
LU publication?
yes
id
064778bb-adb9-4627-b152-6ee1767b6408 (old id 2494232)
date added to LUP
2012-06-04 14:16:24
date last changed
2017-01-01 04:10:47
@article{064778bb-adb9-4627-b152-6ee1767b6408,
  abstract     = {Protein synthesis has been studied for more than half a century, but the atomic details of this complex system, the ribosome, began to be revealed in 1999 and 2000 through crystallographic structure determinations. As with all biomolecular systems, the advent of atomic structures are milestones in the process of relating function to structure. During these 10 years there has been an avalanche in biochemical investigations related to the crystal structures as well as new structures pinpointing specific functional details. Three of the central workers in the field (Venkatraman Ramakrishnan, Thomas Steitz and Ada Yonath) were awarded the Nobel Prize for Chemistry 2009. Even though their work has led to significant leaps in understanding, much remains to be clarified. This review will summarize some of the work so far and the understanding achieved.},
  author       = {Liljas, Anders},
  issn         = {0889-311X},
  keyword      = {GTP,hydrolysis,elongation factors,ribosome,peptidyl transfer,translation},
  language     = {eng},
  number       = {3},
  pages        = {205--223},
  publisher    = {Taylor & Francis},
  series       = {Crystallography Reviews},
  title        = {The ribosome story: An overview of structural studies of protein synthesis on the ribosome},
  url          = {http://dx.doi.org/10.1080/0889311X.2011.587812},
  volume       = {17},
  year         = {2011},
}