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Dietary intake of heme iron and risk of gastric cancer in the European prospective investigation into cancer and nutrition study

Jakszyn, Paula 01; Agudo, Antonio 01; Lujan-Barroso, Leila 01; Bueno-de-Mesquita, H. Bas 50; Jenab, Mazda 03; Navarro, Carmen 04; Palli, Domenico 05; Boeing, Heiner 06; Manjer, Jonas LU and Numans, Mattijs E. 08, et al. (2012) In International Journal of Cancer 130(11). p.2654-2663
Abstract
Even though recent studies suggest that a high intake of heme iron is associated with several types of cancer, epidemiological studies in relation to gastric cancer (GC) are lacking. Our previous results show a positive association between red and processed meat and non cardia gastric cancer, especially in Helicobacter pylori infected subjects. The aim of the study is to investigate the association between heme iron intake and GC risk in the European prospective investigation into cancer and nutrition (EURGAST-EPIC). Dietary intake was assessed by validated center-specific questionnaires. Heme iron was calculated as a type-specific percentage of the total iron content in meat intake, derived from the literature. Antibodies of H. pylori... (More)
Even though recent studies suggest that a high intake of heme iron is associated with several types of cancer, epidemiological studies in relation to gastric cancer (GC) are lacking. Our previous results show a positive association between red and processed meat and non cardia gastric cancer, especially in Helicobacter pylori infected subjects. The aim of the study is to investigate the association between heme iron intake and GC risk in the European prospective investigation into cancer and nutrition (EURGAST-EPIC). Dietary intake was assessed by validated center-specific questionnaires. Heme iron was calculated as a type-specific percentage of the total iron content in meat intake, derived from the literature. Antibodies of H. pylori infection and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control study within the cohort. The study included 481,419 individuals and 444 incident cases of GC that occurred during an average of 8.7 years of followup. We observed a statistically significant association between heme iron intake and GC risk (HR 1.13 95% CI: 1.011.26 for a doubling of intake) adjusted by sex, age, BMI, education level, tobacco smoking and energy intake. The positive association between heme iron and the risk of GC was statistically significant in subjects with plasma vitamin C <39 mmol/l only (log2 HR 1.54 95% CI (1.012.35). We found a positive association between heme iron intake and gastric cancer risk. (Less)
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publication status
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keywords
EPIC, gastric cancer, diet, prospective study, heme iron
in
International Journal of Cancer
volume
130
issue
11
pages
2654 - 2663
publisher
John Wiley & Sons
external identifiers
  • wos:000302013200019
  • scopus:84859159973
ISSN
0020-7136
DOI
10.1002/ijc.26263
language
English
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yes
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9ec434b0-2fb8-493b-8341-64872765792e (old id 2494452)
date added to LUP
2012-05-07 14:36:44
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2017-08-20 03:01:35
@article{9ec434b0-2fb8-493b-8341-64872765792e,
  abstract     = {Even though recent studies suggest that a high intake of heme iron is associated with several types of cancer, epidemiological studies in relation to gastric cancer (GC) are lacking. Our previous results show a positive association between red and processed meat and non cardia gastric cancer, especially in Helicobacter pylori infected subjects. The aim of the study is to investigate the association between heme iron intake and GC risk in the European prospective investigation into cancer and nutrition (EURGAST-EPIC). Dietary intake was assessed by validated center-specific questionnaires. Heme iron was calculated as a type-specific percentage of the total iron content in meat intake, derived from the literature. Antibodies of H. pylori infection and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control study within the cohort. The study included 481,419 individuals and 444 incident cases of GC that occurred during an average of 8.7 years of followup. We observed a statistically significant association between heme iron intake and GC risk (HR 1.13 95% CI: 1.011.26 for a doubling of intake) adjusted by sex, age, BMI, education level, tobacco smoking and energy intake. The positive association between heme iron and the risk of GC was statistically significant in subjects with plasma vitamin C &lt;39 mmol/l only (log2 HR 1.54 95% CI (1.012.35). We found a positive association between heme iron intake and gastric cancer risk.},
  author       = {Jakszyn, Paula 01 and Agudo, Antonio 01 and Lujan-Barroso, Leila 01 and Bueno-de-Mesquita, H. Bas 50 and Jenab, Mazda 03 and Navarro, Carmen 04 and Palli, Domenico 05 and Boeing, Heiner 06 and Manjer, Jonas and Numans, Mattijs E. 08 and Igali, Laszlo 09 and Boutron-Ruault, Marie-Christine 10 and Clavel-Chapelon, Francoise 10 and Morois, Sophie 10 and Grioni, Sara 11 and Panico, CSalvatore 12 and Tumino, Rosario 13 and Sacerdote, Carlotta 14 and Ramon Quiros, J. 15 and Molina-Montes, Esther 16 and Huerta Castano, Jose Ma 4 and Barricarte, Aurelio 17 and Amiano, Pilar 18 and Khaw, Kay-Tee 19 and Wareham, Nicholas 19 and Allen, Naomi E. 20 and Key, Timothy J. 20 and Jeurnink, Suzanne M. 50 and Peeters, Petra H. M. 08 and Bamia, Christina 22 and Valanou, Elisabeth 22. 23 and Trichopoulou, Antonia 22. 23 and Kaaks, Rudolf 24 and Lukanova, Annekatrin 24 and Bergmann, Manuela M. 06 and Lindkvist, Bjorn 25 and Stenling, Roger 26 and Johansson, Ingegerd 27 and Dahm, Christina C. 28. 29 and Overvad, Kim 29 and Olsen, Anja 30 and Tjonneland, Anne 30 and Skeie, Guri 31 and Ragnhild Broderstad, Ann 31 and Lund, Eiliv 31 and Michaud, Dominique S. 32 and Mouw, Traci 32 and Riboli, Elio 33 and Gonzalez, Carlos A. 01},
  issn         = {0020-7136},
  keyword      = {EPIC,gastric cancer,diet,prospective study,heme iron},
  language     = {eng},
  number       = {11},
  pages        = {2654--2663},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Dietary intake of heme iron and risk of gastric cancer in the European prospective investigation into cancer and nutrition study},
  url          = {http://dx.doi.org/10.1002/ijc.26263},
  volume       = {130},
  year         = {2012},
}