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pH-responsive liposome-templated polyelectrolyte nanocapsules

Cuomo, Francesca; Lopez, Francesco; Ceglie, Andrea; Maiuro, Lucia; Miguel, Maria G. and Lindman, Björn LU (2012) In Soft Matter 8(16). p.4415-4420
Abstract
Hollow nanocapsules made of polyelectrolytes, extensively useful for biomedical and biotechnological applications, are produced with a simple Layer-by-Layer approach using liposomes as template. The biocompatible polymers, alginate and chitosan, are alternatively adsorbed onto liposomes allowing the achievement of small size hollow nanocapsules with an average diameter of similar to 280 nm. Hollow nanocapsules, positively as well as negatively charged, depending on the number of layers, can be produced in a reproducible way. The produced nanocapsules are demonstrated to be sensitive to pH changes of the environment because of the behaviour of the polyelectrolytes composing the multishell walls; in fact they exhibit major variations in size... (More)
Hollow nanocapsules made of polyelectrolytes, extensively useful for biomedical and biotechnological applications, are produced with a simple Layer-by-Layer approach using liposomes as template. The biocompatible polymers, alginate and chitosan, are alternatively adsorbed onto liposomes allowing the achievement of small size hollow nanocapsules with an average diameter of similar to 280 nm. Hollow nanocapsules, positively as well as negatively charged, depending on the number of layers, can be produced in a reproducible way. The produced nanocapsules are demonstrated to be sensitive to pH changes of the environment because of the behaviour of the polyelectrolytes composing the multishell walls; in fact they exhibit major variations in size depending on the bulk solution pH. Measurements of dynamic light scattering (DLS) and of zeta-potentials as well as scanning electron microscopy (SEM) observations demonstrate a correlation between the pH and the shrinking/swelling of the nanocapsules. While nanocapsules having chitosan as outer layer are stable only at acidic pH, nanocapsules having alginate as outer layer remain stable at all the pHs used in this study (pH 4.6 to 8). The pH-optimum for the shrinking event is in the acidic range. The role of both the polymers in the shrinking/swelling event is demonstrated by comparing nanocapsule populations with alginate (7 layers) or chitosan (8 layers) as the outer layer. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Soft Matter
volume
8
issue
16
pages
4415 - 4420
publisher
Royal Society of Chemistry
external identifiers
  • wos:000302030200016
  • scopus:84859308207
ISSN
1744-6848
DOI
10.1039/c2sm07388a
language
English
LU publication?
yes
id
86464290-44bf-4a1c-9451-a9d6fe877673 (old id 2494916)
date added to LUP
2012-05-10 13:34:26
date last changed
2017-11-12 03:48:27
@article{86464290-44bf-4a1c-9451-a9d6fe877673,
  abstract     = {Hollow nanocapsules made of polyelectrolytes, extensively useful for biomedical and biotechnological applications, are produced with a simple Layer-by-Layer approach using liposomes as template. The biocompatible polymers, alginate and chitosan, are alternatively adsorbed onto liposomes allowing the achievement of small size hollow nanocapsules with an average diameter of similar to 280 nm. Hollow nanocapsules, positively as well as negatively charged, depending on the number of layers, can be produced in a reproducible way. The produced nanocapsules are demonstrated to be sensitive to pH changes of the environment because of the behaviour of the polyelectrolytes composing the multishell walls; in fact they exhibit major variations in size depending on the bulk solution pH. Measurements of dynamic light scattering (DLS) and of zeta-potentials as well as scanning electron microscopy (SEM) observations demonstrate a correlation between the pH and the shrinking/swelling of the nanocapsules. While nanocapsules having chitosan as outer layer are stable only at acidic pH, nanocapsules having alginate as outer layer remain stable at all the pHs used in this study (pH 4.6 to 8). The pH-optimum for the shrinking event is in the acidic range. The role of both the polymers in the shrinking/swelling event is demonstrated by comparing nanocapsule populations with alginate (7 layers) or chitosan (8 layers) as the outer layer.},
  author       = {Cuomo, Francesca and Lopez, Francesco and Ceglie, Andrea and Maiuro, Lucia and Miguel, Maria G. and Lindman, Björn},
  issn         = {1744-6848},
  language     = {eng},
  number       = {16},
  pages        = {4415--4420},
  publisher    = {Royal Society of Chemistry},
  series       = {Soft Matter},
  title        = {pH-responsive liposome-templated polyelectrolyte nanocapsules},
  url          = {http://dx.doi.org/10.1039/c2sm07388a},
  volume       = {8},
  year         = {2012},
}