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Geographical Differences in Autoantibodies and Anti-infectious Agents Antibodies Among Healthy Adults

Shapira, Yinon; Katz, Bat-Sheva Porat; Gilburd, Boris; Barzilai, Ori; Ram, Maya; Blank, Miri; Lindeberg, Staffan LU ; Frostegard, Johan; Anaya, Juan-Manuel and Bizzaro, Nicola, et al. (2012) In Clinical Reviews in Allergy & Immunology 42(2). p.154-163
Abstract
Much is known about the geoepidemiology of defined autoimmune diseases (AD); however, there is currently limited data regarding the prevalence of autoantibodies among healthy populations of different geographical areas. The aim of this study was to evaluate a large profile of autoantibodies in healthy adults from distinct global regions as well as the prevalence of anti-infectious agents antibodies in those regions. Sera samples from 557 healthy donors were obtained at six centers located in different countries (i.e., Italy, Netherlands, Israel, Mexico, Columbia, Papua New Guinea (Kitavans)). Sera were tested for the presence of antinuclear antibodies (ANA) and autoantibodies associated with thrombophilia, vasculitis, and gastrointestinal... (More)
Much is known about the geoepidemiology of defined autoimmune diseases (AD); however, there is currently limited data regarding the prevalence of autoantibodies among healthy populations of different geographical areas. The aim of this study was to evaluate a large profile of autoantibodies in healthy adults from distinct global regions as well as the prevalence of anti-infectious agents antibodies in those regions. Sera samples from 557 healthy donors were obtained at six centers located in different countries (i.e., Italy, Netherlands, Israel, Mexico, Columbia, Papua New Guinea (Kitavans)). Sera were tested for the presence of antinuclear antibodies (ANA) and autoantibodies associated with thrombophilia, vasculitis, and gastrointestinal (GI) disease. Sera samples were also screened for antibodies against infectious agents (i.e., EBV, CMV, HBV, Helicobacter pylori, Treponema pallidum, and Toxoplasma gondii). Tests were performed using the BioPlex 2200 or ELISA kits (Bio-Rad Laboratories, USA). We found a significant gradient of ANA positivity among the groups: 45% of Columbians, 38% of Kitavans, 26% of Mexicans, 12% of Italians, 12% of Dutch, and 11% of Israelis were ANA positive. Geographical differences were also observed regarding the prevalence of specific autoantibodies, namely ANA: anti-dsDNA, chromatin, SmRNP, Ro/SSA, La/SSB, Scl70; GI associated: antigliadin; and thrombophilia-associated: anti-beta 2GP1 and prothrombin. Additionally, significant differences were observed regarding serological markers of all infectious agents screened. The observed variance between healthy ethno-geographical distinct populations in prevalence of autoantibodies may represent different genetic or environmental (e.g., prior exposure to infection) influences. Thus may illuminate possible causes of geoepidemiological differences in AD. (Less)
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keywords
Antiphospholipid antibodies, Infectious agents, Antigliadin, Antinuclear antibodies, Ethnicity, Geoepidemiology, Autoimmunity
in
Clinical Reviews in Allergy & Immunology
volume
42
issue
2
pages
154 - 163
publisher
Humana Press
external identifiers
  • wos:000301569400006
  • scopus:84862892486
ISSN
1080-0549
DOI
10.1007/s12016-010-8241-z
language
English
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yes
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e783d0d3-0fbd-4030-9f14-3c13e81808e6 (old id 2494985)
date added to LUP
2012-05-07 14:11:27
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2017-07-02 04:13:38
@article{e783d0d3-0fbd-4030-9f14-3c13e81808e6,
  abstract     = {Much is known about the geoepidemiology of defined autoimmune diseases (AD); however, there is currently limited data regarding the prevalence of autoantibodies among healthy populations of different geographical areas. The aim of this study was to evaluate a large profile of autoantibodies in healthy adults from distinct global regions as well as the prevalence of anti-infectious agents antibodies in those regions. Sera samples from 557 healthy donors were obtained at six centers located in different countries (i.e., Italy, Netherlands, Israel, Mexico, Columbia, Papua New Guinea (Kitavans)). Sera were tested for the presence of antinuclear antibodies (ANA) and autoantibodies associated with thrombophilia, vasculitis, and gastrointestinal (GI) disease. Sera samples were also screened for antibodies against infectious agents (i.e., EBV, CMV, HBV, Helicobacter pylori, Treponema pallidum, and Toxoplasma gondii). Tests were performed using the BioPlex 2200 or ELISA kits (Bio-Rad Laboratories, USA). We found a significant gradient of ANA positivity among the groups: 45% of Columbians, 38% of Kitavans, 26% of Mexicans, 12% of Italians, 12% of Dutch, and 11% of Israelis were ANA positive. Geographical differences were also observed regarding the prevalence of specific autoantibodies, namely ANA: anti-dsDNA, chromatin, SmRNP, Ro/SSA, La/SSB, Scl70; GI associated: antigliadin; and thrombophilia-associated: anti-beta 2GP1 and prothrombin. Additionally, significant differences were observed regarding serological markers of all infectious agents screened. The observed variance between healthy ethno-geographical distinct populations in prevalence of autoantibodies may represent different genetic or environmental (e.g., prior exposure to infection) influences. Thus may illuminate possible causes of geoepidemiological differences in AD.},
  author       = {Shapira, Yinon and Katz, Bat-Sheva Porat and Gilburd, Boris and Barzilai, Ori and Ram, Maya and Blank, Miri and Lindeberg, Staffan and Frostegard, Johan and Anaya, Juan-Manuel and Bizzaro, Nicola and Jara, Luis J. and Damoiseaux, Jan and Shoenfeld, Yehuda and Levin, Nancy Agmon},
  issn         = {1080-0549},
  keyword      = {Antiphospholipid antibodies,Infectious agents,Antigliadin,Antinuclear antibodies,Ethnicity,Geoepidemiology,Autoimmunity},
  language     = {eng},
  number       = {2},
  pages        = {154--163},
  publisher    = {Humana Press},
  series       = {Clinical Reviews in Allergy & Immunology},
  title        = {Geographical Differences in Autoantibodies and Anti-infectious Agents Antibodies Among Healthy Adults},
  url          = {http://dx.doi.org/10.1007/s12016-010-8241-z},
  volume       = {42},
  year         = {2012},
}