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Pathogenesis and management of pain in osteoarthritis

Dieppe, PA and Lohmander, Stefan LU (2005) In The Lancet 365(9463). p.965-973
Abstract
The term osteoarthritis describes a common, age-related, heterogeneous group of disorders characterised pathologically by focal areas of loss of articular cartilage in synovial joints, associated with varying degrees of orsteophyte formation, subchondral bone change, and synovitis. joint damage is caused by a mixture of systemic factors that predispose to the disease, and local mechanical factors that dictate its distribution and severity. Various genetic abnormalities have been described, but most sporadic osteoarthritis probably depends on minor contributions from several genetic loci. Osteoarthritic joint damage may be associated with clinical problems, but the severity of joint disease is only weakly related to that of the clinical... (More)
The term osteoarthritis describes a common, age-related, heterogeneous group of disorders characterised pathologically by focal areas of loss of articular cartilage in synovial joints, associated with varying degrees of orsteophyte formation, subchondral bone change, and synovitis. joint damage is caused by a mixture of systemic factors that predispose to the disease, and local mechanical factors that dictate its distribution and severity. Various genetic abnormalities have been described, but most sporadic osteoarthritis probably depends on minor contributions from several genetic loci. Osteoarthritic joint damage may be associated with clinical problems, but the severity of joint disease is only weakly related to that of the clinical problem. For this reason the associations and pathogenesis of pain are in as much need of investigation as joint damage. Subchondral bone and synovium may be responsible for nociceptive stimuli, and peripheral neuronal sensitisation. is an important feature, and can result in normal activities (such as walking) causing pain. Central pain sensitisation can also occur, and psychosocial factors are important determinants of pain severity. We present a stepwise approach to the management of osteoarthritis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Lancet
volume
365
issue
9463
pages
965 - 973
publisher
Elsevier Limited
external identifiers
  • wos:000227559800030
  • scopus:15844390942
ISSN
1474-547X
DOI
10.1016/S0140-6736(05)71086-2
language
English
LU publication?
yes
id
66149555-0f21-4f6b-b1f0-c74b0ee6adc5 (old id 249903)
date added to LUP
2007-08-22 08:54:01
date last changed
2017-11-12 03:29:20
@article{66149555-0f21-4f6b-b1f0-c74b0ee6adc5,
  abstract     = {The term osteoarthritis describes a common, age-related, heterogeneous group of disorders characterised pathologically by focal areas of loss of articular cartilage in synovial joints, associated with varying degrees of orsteophyte formation, subchondral bone change, and synovitis. joint damage is caused by a mixture of systemic factors that predispose to the disease, and local mechanical factors that dictate its distribution and severity. Various genetic abnormalities have been described, but most sporadic osteoarthritis probably depends on minor contributions from several genetic loci. Osteoarthritic joint damage may be associated with clinical problems, but the severity of joint disease is only weakly related to that of the clinical problem. For this reason the associations and pathogenesis of pain are in as much need of investigation as joint damage. Subchondral bone and synovium may be responsible for nociceptive stimuli, and peripheral neuronal sensitisation. is an important feature, and can result in normal activities (such as walking) causing pain. Central pain sensitisation can also occur, and psychosocial factors are important determinants of pain severity. We present a stepwise approach to the management of osteoarthritis.},
  author       = {Dieppe, PA and Lohmander, Stefan},
  issn         = {1474-547X},
  language     = {eng},
  number       = {9463},
  pages        = {965--973},
  publisher    = {Elsevier Limited},
  series       = {The Lancet},
  title        = {Pathogenesis and management of pain in osteoarthritis},
  url          = {http://dx.doi.org/10.1016/S0140-6736(05)71086-2},
  volume       = {365},
  year         = {2005},
}