Advanced

Location and nature of the residues important for ligand recognition in G-protein coupled receptors

Bywater, Robert P. LU (2005) In Journal of Molecular Recognition 18(1). p.60-72
Abstract
The overall structure of the biogenic amine subclass of the G-protein-coupled receptors, and of their ligand binding sites, is discussed with the aim of highlighting the major structural features of these receptors that are responsible for ligand recognition. A comparison is made between biogenic amine receptors, peptide receptors of the rhodopsin class, and the secretin receptors which all have peptide ligands. The question of where the peptide ligands bind, whether at extracellular sites or within the transmembrane helix bundle, is discussed. The suitability of the rhodopsin crystal structure as a template for construction of homology models is discussed and it is concluded that there are many reasons why a caution should be issued... (More)
The overall structure of the biogenic amine subclass of the G-protein-coupled receptors, and of their ligand binding sites, is discussed with the aim of highlighting the major structural features of these receptors that are responsible for ligand recognition. A comparison is made between biogenic amine receptors, peptide receptors of the rhodopsin class, and the secretin receptors which all have peptide ligands. The question of where the peptide ligands bind, whether at extracellular sites or within the transmembrane helix bundle, is discussed. The suitability of the rhodopsin crystal structure as a template for construction of homology models is discussed and it is concluded that there are many reasons why a caution should be issued against using it uncritically. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ligand binding site, ligand binding residue, receptor, GPCR, antitarget, target
in
Journal of Molecular Recognition
volume
18
issue
1
pages
60 - 72
publisher
John Wiley & Sons
external identifiers
  • wos:000227612900004
  • scopus:11244255332
ISSN
1099-1352
DOI
10.1002/jmr.685
language
English
LU publication?
yes
id
84086829-5b80-447b-98e7-1a0bf610a718 (old id 249921)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15386622&dopt=Abstract
date added to LUP
2007-08-16 12:42:58
date last changed
2017-10-22 03:48:28
@article{84086829-5b80-447b-98e7-1a0bf610a718,
  abstract     = {The overall structure of the biogenic amine subclass of the G-protein-coupled receptors, and of their ligand binding sites, is discussed with the aim of highlighting the major structural features of these receptors that are responsible for ligand recognition. A comparison is made between biogenic amine receptors, peptide receptors of the rhodopsin class, and the secretin receptors which all have peptide ligands. The question of where the peptide ligands bind, whether at extracellular sites or within the transmembrane helix bundle, is discussed. The suitability of the rhodopsin crystal structure as a template for construction of homology models is discussed and it is concluded that there are many reasons why a caution should be issued against using it uncritically.},
  author       = {Bywater, Robert P.},
  issn         = {1099-1352},
  keyword      = {ligand binding site,ligand binding residue,receptor,GPCR,antitarget,target},
  language     = {eng},
  number       = {1},
  pages        = {60--72},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Molecular Recognition},
  title        = {Location and nature of the residues important for ligand recognition in G-protein coupled receptors},
  url          = {http://dx.doi.org/10.1002/jmr.685},
  volume       = {18},
  year         = {2005},
}