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Cigarette smoking accelerates progression of alcoholic chronic pancreatitis

Maisonneuve, P; Lowenfels, A B; Mullhaupt, B; Cavallini, G; Lankisch, P G; Andersen, J R; DiMagno, E P; Andrén-Sandberg, Åke LU ; Domellof, L and Frulloni, L, et al. (2005) In Gut 54(4). p.510-514
Abstract
Background: Smoking is a recognised risk factor for pancreatic cancer and has been associated with chronic pancreatitis and also with type II diabetes. Aims: The aim of this study was to investigate the effect of tobacco on the age of diagnosis of pancreatitis and progression of disease, as measured by the appearance of calcification and diabetes. Patients: We used data from a retrospective cohort of 934 patients with chronic alcoholic pancreatitis where information on smoking was available, who were diagnosed and followed in clinical centres in five countries. Methods: We compared age at diagnosis of pancreatitis in smokers versus non-smokers, and used the Cox proportional hazards model to evaluate the effects of tobacco on the... (More)
Background: Smoking is a recognised risk factor for pancreatic cancer and has been associated with chronic pancreatitis and also with type II diabetes. Aims: The aim of this study was to investigate the effect of tobacco on the age of diagnosis of pancreatitis and progression of disease, as measured by the appearance of calcification and diabetes. Patients: We used data from a retrospective cohort of 934 patients with chronic alcoholic pancreatitis where information on smoking was available, who were diagnosed and followed in clinical centres in five countries. Methods: We compared age at diagnosis of pancreatitis in smokers versus non-smokers, and used the Cox proportional hazards model to evaluate the effects of tobacco on the development of calcification and diabetes, after adjustment for age, sex, centre, and alcohol consumption. Results: The diagnosis of pancreatitis was made, on average, 4.7 years earlier in smokers than in nonsmokers (p=0.001). Tobacco smoking increased significantly the risk of pancreatic calcifications ( hazard ratio (HR) 4.9 (95% confidence interval (CI) 2.3-10.5) for smokers v non-smokers) and to a lesser extent the risk of diabetes (HR 2.3 (95% CI 1.2-4.2)) during the course of pancreatitis. Conclusions: In this study, tobacco smoking was associated with earlier diagnosis of chronic alcoholic pancreatitis and with the appearance of calcifications and diabetes, independent of alcohol consumption. (Less)
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publication status
published
subject
in
Gut
volume
54
issue
4
pages
510 - 514
publisher
BMJ Publishing Group
external identifiers
  • pmid:15753536
  • wos:000227471000017
  • scopus:20144370028
ISSN
1468-3288
DOI
10.1136/gut.2004.039263
language
English
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yes
id
98d5d2c0-04cd-445f-aec9-b0c17f666038 (old id 249988)
date added to LUP
2007-08-07 16:15:24
date last changed
2017-10-22 04:38:52
@article{98d5d2c0-04cd-445f-aec9-b0c17f666038,
  abstract     = {Background: Smoking is a recognised risk factor for pancreatic cancer and has been associated with chronic pancreatitis and also with type II diabetes. Aims: The aim of this study was to investigate the effect of tobacco on the age of diagnosis of pancreatitis and progression of disease, as measured by the appearance of calcification and diabetes. Patients: We used data from a retrospective cohort of 934 patients with chronic alcoholic pancreatitis where information on smoking was available, who were diagnosed and followed in clinical centres in five countries. Methods: We compared age at diagnosis of pancreatitis in smokers versus non-smokers, and used the Cox proportional hazards model to evaluate the effects of tobacco on the development of calcification and diabetes, after adjustment for age, sex, centre, and alcohol consumption. Results: The diagnosis of pancreatitis was made, on average, 4.7 years earlier in smokers than in nonsmokers (p=0.001). Tobacco smoking increased significantly the risk of pancreatic calcifications ( hazard ratio (HR) 4.9 (95% confidence interval (CI) 2.3-10.5) for smokers v non-smokers) and to a lesser extent the risk of diabetes (HR 2.3 (95% CI 1.2-4.2)) during the course of pancreatitis. Conclusions: In this study, tobacco smoking was associated with earlier diagnosis of chronic alcoholic pancreatitis and with the appearance of calcifications and diabetes, independent of alcohol consumption.},
  author       = {Maisonneuve, P and Lowenfels, A B and Mullhaupt, B and Cavallini, G and Lankisch, P G and Andersen, J R and DiMagno, E P and Andrén-Sandberg, Åke and Domellof, L and Frulloni, L and Ammann, R W},
  issn         = {1468-3288},
  language     = {eng},
  number       = {4},
  pages        = {510--514},
  publisher    = {BMJ Publishing Group},
  series       = {Gut},
  title        = {Cigarette smoking accelerates progression of alcoholic chronic pancreatitis},
  url          = {http://dx.doi.org/10.1136/gut.2004.039263},
  volume       = {54},
  year         = {2005},
}