GAD2 on chromosome 10p12 is a candidate gene for human obesity.
(2003) In PLoS Biology 1(3).- Abstract
- The gene GAD2 encoding the glutamic acid decarboxylase enzyme (GAD65) is a positional candidate gene for obesity on Chromosome 10p11-12, a susceptibility locus for morbid obesity in four independent ethnic populations. GAD65 catalyzes the formation of gamma-aminobutyric acid (GABA), which interacts with neuropeptide Y in the paraventricular nucleus to contribute to stimulate food intake. A case-control study (575 morbidly obese and 646 control subjects) analyzing GAD2 variants identified both a protective haplotype, including the most frequent alleles of single nucleotide polymorphisms (SNPs) +61450 C>A and +83897 T>A (OR = 0.81, 95% CI [0.681-0.972], p = 0.0049) and an at-risk SNP (-243 A>G) for morbid obesity (OR = 1.3, 95% CI... (More)
- The gene GAD2 encoding the glutamic acid decarboxylase enzyme (GAD65) is a positional candidate gene for obesity on Chromosome 10p11-12, a susceptibility locus for morbid obesity in four independent ethnic populations. GAD65 catalyzes the formation of gamma-aminobutyric acid (GABA), which interacts with neuropeptide Y in the paraventricular nucleus to contribute to stimulate food intake. A case-control study (575 morbidly obese and 646 control subjects) analyzing GAD2 variants identified both a protective haplotype, including the most frequent alleles of single nucleotide polymorphisms (SNPs) +61450 C>A and +83897 T>A (OR = 0.81, 95% CI [0.681-0.972], p = 0.0049) and an at-risk SNP (-243 A>G) for morbid obesity (OR = 1.3, 95% CI [1.053-1.585], p = 0.014). Furthermore, familial-based analyses confirmed the association with the obesity of SNP +61450 C>A and +83897 T>A haplotype (chi(2) = 7.637, p = 0.02). In the murine insulinoma cell line betaTC3, the G at-risk allele of SNP -243 A>G in (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1127385
- author
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS Biology
- volume
- 1
- issue
- 3
- article number
- 68
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- scopus:2642512097
- ISSN
- 1545-7885
- DOI
- 10.1371/journal.pbio.0000068
- language
- English
- LU publication?
- no
- id
- 249bf502-7ca5-4a32-af30-8eab136cebd9 (old id 1127385)
- date added to LUP
- 2016-04-01 16:22:43
- date last changed
- 2022-01-28 19:17:45
@article{249bf502-7ca5-4a32-af30-8eab136cebd9, abstract = {{The gene GAD2 encoding the glutamic acid decarboxylase enzyme (GAD65) is a positional candidate gene for obesity on Chromosome 10p11-12, a susceptibility locus for morbid obesity in four independent ethnic populations. GAD65 catalyzes the formation of gamma-aminobutyric acid (GABA), which interacts with neuropeptide Y in the paraventricular nucleus to contribute to stimulate food intake. A case-control study (575 morbidly obese and 646 control subjects) analyzing GAD2 variants identified both a protective haplotype, including the most frequent alleles of single nucleotide polymorphisms (SNPs) +61450 C>A and +83897 T>A (OR = 0.81, 95% CI [0.681-0.972], p = 0.0049) and an at-risk SNP (-243 A>G) for morbid obesity (OR = 1.3, 95% CI [1.053-1.585], p = 0.014). Furthermore, familial-based analyses confirmed the association with the obesity of SNP +61450 C>A and +83897 T>A haplotype (chi(2) = 7.637, p = 0.02). In the murine insulinoma cell line betaTC3, the G at-risk allele of SNP -243 A>G in}}, author = {{Boutin, Philippe and Dina, Christian and Vasseur, Francis and Dubois, Séverine and Corset, Laetitia and Séron, Karin and Bekris, Lynn and Cabellon, Janice and Neve, Bernadette and Vasseur-Delannoy, Valérie and Chikri, Mohamed and Charles, M. Aline and Clement, Karine and Lernmark, Åke and Froguel, Philippe}}, issn = {{1545-7885}}, language = {{eng}}, number = {{3}}, publisher = {{Public Library of Science (PLoS)}}, series = {{PLoS Biology}}, title = {{GAD2 on chromosome 10p12 is a candidate gene for human obesity.}}, url = {{http://dx.doi.org/10.1371/journal.pbio.0000068}}, doi = {{10.1371/journal.pbio.0000068}}, volume = {{1}}, year = {{2003}}, }