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Prognostic factors for outcome of benign skull base lesions: The vestibular schwannoma model

Al-Shudifat, Abdul Rahman Mohummad LU (2017)
Abstract
Skull base tumors comprise different pathological entities, making establishment of management guidelines challenging. All trials to define the ideal outcome measurement which can be reflected on treatment and prognosis improvement, are not conclusive with a lot of methodological criticism.
In this thesis, I took vestibular schwannoma (homogenous pathology, different skull base approaches, may affect multiple cranial nerves) as a model for skull base tumors to study outcomes and their measures. We used different categories of outcomes: neurological, functional and quality of life using retrospective and prospective data collection.
I could elicit a new work capacity score, novel morbidity score, independent life score and facial... (More)
Skull base tumors comprise different pathological entities, making establishment of management guidelines challenging. All trials to define the ideal outcome measurement which can be reflected on treatment and prognosis improvement, are not conclusive with a lot of methodological criticism.
In this thesis, I took vestibular schwannoma (homogenous pathology, different skull base approaches, may affect multiple cranial nerves) as a model for skull base tumors to study outcomes and their measures. We used different categories of outcomes: neurological, functional and quality of life using retrospective and prospective data collection.
I could elicit a new work capacity score, novel morbidity score, independent life score and facial analogue scale. Some of them reproduced in more than one article. With testing of these outcome measures against a battery of per operative factors aiming to find out prognostic factors that may steer management line in vestibular schwannoma in particular and skull base tumors in general.
To conclude, new methods not discussed or used before for this pathology were introduced. Indeed, further work is needed, using these new measures to validate them and making them reproducible. (Less)
Please use this url to cite or link to this publication:
author
supervisor
opponent
  • professor Lund-Johansen, Morten, Haukeland University Hospital, Bergen
organization
publishing date
type
Thesis
publication status
published
subject
keywords
Skull base tumors, Vestibular schwannoma, Prognostic factors
pages
68 pages
publisher
Lund University, Faculty of Medicine
defense location
Segerfalksalen, BMC A10, Sölvegatan 17, Lund.
defense date
2017-10-13 13:00
ISBN
978-91-7619-531-4
language
English
LU publication?
yes
id
24a3de0b-1dcd-44c8-a836-91f564249b51
date added to LUP
2017-09-21 13:37:32
date last changed
2017-11-10 10:51:38
@phdthesis{24a3de0b-1dcd-44c8-a836-91f564249b51,
  abstract     = {Skull base tumors comprise different pathological entities, making establishment of management guidelines challenging. All trials to define the ideal outcome measurement which can be reflected on treatment and prognosis improvement, are not conclusive with a lot of methodological criticism.<br/>In this thesis, I took vestibular schwannoma (homogenous pathology, different skull base approaches, may affect multiple cranial nerves) as a model for skull base tumors to study outcomes and their measures. We used different categories of outcomes: neurological, functional and quality of life using retrospective and prospective data collection.<br/>I could elicit a new work capacity score, novel morbidity score, independent life score and facial analogue scale. Some of them reproduced in more than one article. With testing of these outcome measures against a battery of per operative factors aiming to find out prognostic factors that may steer management line in vestibular schwannoma in particular and skull base tumors in general.<br/>To conclude, new methods not discussed or used before for this pathology were introduced. Indeed, further work is needed, using these new measures to validate them and making them reproducible.},
  author       = {Al-Shudifat, Abdul Rahman Mohummad},
  isbn         = {978-91-7619-531-4},
  keyword      = {Skull base tumors,Vestibular schwannoma,Prognostic factors},
  language     = {eng},
  pages        = {68},
  publisher    = {Lund University, Faculty of Medicine},
  school       = {Lund University},
  title        = {Prognostic factors for outcome of benign skull base lesions: The vestibular schwannoma model},
  year         = {2017},
}