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Patch testing with hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC) - a multicentre study of the Swedish Contact Dermatitis Research Group

Engfeldt, Malin LU ; Hagvall, Lina; Isaksson, Marléne LU ; Matura, Mihály; Mowitz, Martin LU ; Ryberg, Kristina; Stenberg, Berndt; Svedman, Cecilia LU and Bruze, Magnus LU (2017) In Contact Dermatitis 76(1). p.34-39
Abstract

Background: In 2014, the fragrance hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC) was excluded from the Swedish baseline series. Objectives: To study (i) whether fragrance mix (FM) II with 5% HICC detects more positive reactions than FM II with 2.5% HICC, and (ii) the reproducibility of patch testing with HICC. Methods: Two thousand one hundred and eighteen dermatitis patients at five Swedish dermatology departments were consecutively tested with FM II 14% pet., FM II 16.5% pet., and duplicate preparations of HICC 5% pet. Results: Of the patients, 3.2% reacted to FM II 14%, and 1.5% reacted to HICC. Separate testing with HICC detected 0.3% reactions without concomitant reactivity to FM II. FM II with 5% HICC did not give rise to... (More)

Background: In 2014, the fragrance hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC) was excluded from the Swedish baseline series. Objectives: To study (i) whether fragrance mix (FM) II with 5% HICC detects more positive reactions than FM II with 2.5% HICC, and (ii) the reproducibility of patch testing with HICC. Methods: Two thousand one hundred and eighteen dermatitis patients at five Swedish dermatology departments were consecutively tested with FM II 14% pet., FM II 16.5% pet., and duplicate preparations of HICC 5% pet. Results: Of the patients, 3.2% reacted to FM II 14%, and 1.5% reacted to HICC. Separate testing with HICC detected 0.3% reactions without concomitant reactivity to FM II. FM II with 5% HICC did not give rise to more irritant reactions or signs of active sensitization than FM II with 2.5% HICC. Patch testing with duplicate applications of HICC increased the overall prevalence of HICC contact allergy to 1.9%. Conclusion: FM II with 5% HICC does not detect more positive reactions than FM II with 2.5% HICC. Separate testing with HICC does not detect a sufficient proportion of patients who react only to HICC, without concomitant reactions to FM II, to warrant its inclusion in a baseline series.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Allergic contact dermatitis, Contact allergy, Delayed hypersensitivity, Dose/area, Fragrance, Fragrance mix II, High-performance liquid chromatography, Hydroxyisohexyl 3-cyclohexene carboxaldehyde
in
Contact Dermatitis
volume
76
issue
1
pages
34 - 39
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • scopus:84995380272
  • wos:000390785500005
ISSN
0105-1873
DOI
10.1111/cod.12699
language
English
LU publication?
yes
id
24bcfea8-8847-474c-bfaf-5c20bbfef83b
date added to LUP
2016-12-05 10:34:04
date last changed
2018-10-07 04:49:51
@article{24bcfea8-8847-474c-bfaf-5c20bbfef83b,
  abstract     = {<p>Background: In 2014, the fragrance hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC) was excluded from the Swedish baseline series. Objectives: To study (i) whether fragrance mix (FM) II with 5% HICC detects more positive reactions than FM II with 2.5% HICC, and (ii) the reproducibility of patch testing with HICC. Methods: Two thousand one hundred and eighteen dermatitis patients at five Swedish dermatology departments were consecutively tested with FM II 14% pet., FM II 16.5% pet., and duplicate preparations of HICC 5% pet. Results: Of the patients, 3.2% reacted to FM II 14%, and 1.5% reacted to HICC. Separate testing with HICC detected 0.3% reactions without concomitant reactivity to FM II. FM II with 5% HICC did not give rise to more irritant reactions or signs of active sensitization than FM II with 2.5% HICC. Patch testing with duplicate applications of HICC increased the overall prevalence of HICC contact allergy to 1.9%. Conclusion: FM II with 5% HICC does not detect more positive reactions than FM II with 2.5% HICC. Separate testing with HICC does not detect a sufficient proportion of patients who react only to HICC, without concomitant reactions to FM II, to warrant its inclusion in a baseline series.</p>},
  author       = {Engfeldt, Malin and Hagvall, Lina and Isaksson, Marléne and Matura, Mihály and Mowitz, Martin and Ryberg, Kristina and Stenberg, Berndt and Svedman, Cecilia and Bruze, Magnus},
  issn         = {0105-1873},
  keyword      = {Allergic contact dermatitis,Contact allergy,Delayed hypersensitivity,Dose/area,Fragrance,Fragrance mix II,High-performance liquid chromatography,Hydroxyisohexyl 3-cyclohexene carboxaldehyde},
  language     = {eng},
  number       = {1},
  pages        = {34--39},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Patch testing with hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC) - a multicentre study of the Swedish Contact Dermatitis Research Group},
  url          = {http://dx.doi.org/10.1111/cod.12699},
  volume       = {76},
  year         = {2017},
}