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Comparative cytological and histological assessment of 828 primary soft tissue and bone lesions, and proposal for a system for reporting soft tissue cytopathology

Köster, Jan LU ; Ghanei, Iman LU and Domanski, Henryk A. LU (2021) In Cytopathology 32(1). p.7-19
Abstract

Introduction: The aim of the study was to evaluate the diagnostic utility of fine needle aspiration (FNA) cytology and core needle biopsies (CNBs) in a series of primary soft tissue and bone lesions and to test a possible system for reporting results of FNA cytology of soft tissue lesion. Methods: This retrospective study encompassed 828 primary soft tissue and bone lesions, analysed with FNA, CNB and/or surgical specimen in order to perform sensitivity/specificity as well as accuracy analyses. The series was then used to test a system for reporting soft tissue cytopathology with six categories and the risk of malignancy in each category was calculated. Results: With a malignant diagnosis defined as positive test result, FNA and CNB... (More)

Introduction: The aim of the study was to evaluate the diagnostic utility of fine needle aspiration (FNA) cytology and core needle biopsies (CNBs) in a series of primary soft tissue and bone lesions and to test a possible system for reporting results of FNA cytology of soft tissue lesion. Methods: This retrospective study encompassed 828 primary soft tissue and bone lesions, analysed with FNA, CNB and/or surgical specimen in order to perform sensitivity/specificity as well as accuracy analyses. The series was then used to test a system for reporting soft tissue cytopathology with six categories and the risk of malignancy in each category was calculated. Results: With a malignant diagnosis defined as positive test result, FNA and CNB analysis showed sensitivity of 87% and 94%, respectively, and specificity of 89% and 95%, respectively. FNA and CNB analyses identified the correct histopathological entity of the examined lesion in 55% and 66%, respectively. The risk of malignancy within the tested categories was non-diagnostic 42%, non-neoplastic 0%, atypia of unknown significance 46%, neoplasm benign 3%, neoplasm of unknown malignant potential 27%, suspicious for malignancy 72% and malignant 97%. Conclusion: FNA cytology is a suitable tool to determine the malignant potential of a sampled soft tissue/bone lesion but is inferior to CNB in defining the correct entity. A standardised reporting system might improve the clinical management of patients with soft tissue tumours examined primarily by FNA cytology.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
biopsy, bone neoplasms, classification, core needle, fine needle, sarcoma, soft tissue neoplasms
in
Cytopathology
volume
32
issue
1
pages
13 pages
publisher
Wiley-Blackwell
external identifiers
  • pmid:32926591
  • scopus:85092644777
ISSN
0956-5507
DOI
10.1111/cyt.12914
language
English
LU publication?
yes
id
24c0c2c2-0354-4a19-bf77-9e8f31f96976
date added to LUP
2020-11-11 13:23:07
date last changed
2024-04-17 18:32:35
@article{24c0c2c2-0354-4a19-bf77-9e8f31f96976,
  abstract     = {{<p>Introduction: The aim of the study was to evaluate the diagnostic utility of fine needle aspiration (FNA) cytology and core needle biopsies (CNBs) in a series of primary soft tissue and bone lesions and to test a possible system for reporting results of FNA cytology of soft tissue lesion. Methods: This retrospective study encompassed 828 primary soft tissue and bone lesions, analysed with FNA, CNB and/or surgical specimen in order to perform sensitivity/specificity as well as accuracy analyses. The series was then used to test a system for reporting soft tissue cytopathology with six categories and the risk of malignancy in each category was calculated. Results: With a malignant diagnosis defined as positive test result, FNA and CNB analysis showed sensitivity of 87% and 94%, respectively, and specificity of 89% and 95%, respectively. FNA and CNB analyses identified the correct histopathological entity of the examined lesion in 55% and 66%, respectively. The risk of malignancy within the tested categories was non-diagnostic 42%, non-neoplastic 0%, atypia of unknown significance 46%, neoplasm benign 3%, neoplasm of unknown malignant potential 27%, suspicious for malignancy 72% and malignant 97%. Conclusion: FNA cytology is a suitable tool to determine the malignant potential of a sampled soft tissue/bone lesion but is inferior to CNB in defining the correct entity. A standardised reporting system might improve the clinical management of patients with soft tissue tumours examined primarily by FNA cytology.</p>}},
  author       = {{Köster, Jan and Ghanei, Iman and Domanski, Henryk A.}},
  issn         = {{0956-5507}},
  keywords     = {{biopsy; bone neoplasms; classification; core needle; fine needle; sarcoma; soft tissue neoplasms}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{7--19}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Cytopathology}},
  title        = {{Comparative cytological and histological assessment of 828 primary soft tissue and bone lesions, and proposal for a system for reporting soft tissue cytopathology}},
  url          = {{http://dx.doi.org/10.1111/cyt.12914}},
  doi          = {{10.1111/cyt.12914}},
  volume       = {{32}},
  year         = {{2021}},
}