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SENSITIVITY ANALYSIS OF THE ICRP BIOKINETIC MODEL PREDICTING THE ACTIVITY OF GD IN LUNGS AND 24-HOUR EXCRETION SAMPLES

Ramljak, Belikse LU ; Malusek, Alexandr ; Eriksson Stenström, Kristina LU and Rääf, Christopher LU orcid (2023) In MEDICAL PHYSICS IN THE BALTIC STATES p.55-59
Abstract
148Gd may contribute to around 50% of the dose from inhalation in case of an accident at the European Spallation Source. Methods for its detection have been developed. They rely on biokinetic models predicting activities of the gamma emitters 146Gd (T1/2= 48.3 d) and 153Gd (T1/2= 240.4 d) as tracers in the lungs, urine, and faeces. The optimal choice of model parameters and associated uncertainties, which propagate to the estimates of the minimum detectable activity of 148Gd (T1/2= 84±4 y), have yet to be systematically investigated. This work presents a step in this direction. The authors have implemented the ICRP biokinetic model for Gd and performed a sensitivity analysis of the model to identify the most influential parameters. They... (More)
148Gd may contribute to around 50% of the dose from inhalation in case of an accident at the European Spallation Source. Methods for its detection have been developed. They rely on biokinetic models predicting activities of the gamma emitters 146Gd (T1/2= 48.3 d) and 153Gd (T1/2= 240.4 d) as tracers in the lungs, urine, and faeces. The optimal choice of model parameters and associated uncertainties, which propagate to the estimates of the minimum detectable activity of 148Gd (T1/2= 84±4 y), have yet to be systematically investigated. This work presents a step in this direction. The authors have implemented the ICRP biokinetic model for Gd and performed a sensitivity analysis of the model to identify the most influential parameters. They will use this knowledge in subsequent uncertainty analysis and determination of the optimal measurement time window. (Less)
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author
; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
ESS, radioactive aerosols, internal dosimetry
host publication
Kaunas University of Technology
series title
MEDICAL PHYSICS IN THE BALTIC STATES
pages
55 - 59
publisher
Kaunas University of Technology
ISSN
1822-5721
language
English
LU publication?
yes
id
24d51eb7-bd44-4883-911a-17d809b9834f
date added to LUP
2023-12-07 16:24:01
date last changed
2024-09-16 08:06:59
@inproceedings{24d51eb7-bd44-4883-911a-17d809b9834f,
  abstract     = {{148Gd may contribute to around 50% of the dose from inhalation in case of an accident at the European Spallation Source. Methods for its detection have been developed. They rely on biokinetic models predicting activities of the gamma emitters 146Gd (T1/2= 48.3 d) and 153Gd (T1/2= 240.4 d) as tracers in the lungs, urine, and faeces. The optimal choice of model parameters and associated uncertainties, which propagate to the estimates of the minimum detectable activity of 148Gd (T1/2= 84±4 y), have yet to be systematically investigated. This work presents a step in this direction. The authors have implemented the ICRP biokinetic model for Gd and performed a sensitivity analysis of the model to identify the most influential parameters. They will use this knowledge in subsequent uncertainty analysis and determination of the optimal measurement time window.}},
  author       = {{Ramljak, Belikse and Malusek, Alexandr and Eriksson Stenström, Kristina and Rääf, Christopher}},
  booktitle    = {{Kaunas University of Technology}},
  issn         = {{1822-5721}},
  keywords     = {{ESS; radioactive aerosols; internal dosimetry}},
  language     = {{eng}},
  month        = {{11}},
  pages        = {{55--59}},
  publisher    = {{Kaunas University of Technology}},
  series       = {{MEDICAL PHYSICS IN THE BALTIC STATES}},
  title        = {{SENSITIVITY ANALYSIS OF THE ICRP BIOKINETIC MODEL PREDICTING THE ACTIVITY OF GD IN LUNGS AND 24-HOUR EXCRETION SAMPLES}},
  url          = {{https://lup.lub.lu.se/search/files/195041251/Manuscript_MPBS_2023_RAMLJAK_MALUSEK.pdf}},
  year         = {{2023}},
}