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MicroRNAs at the crossroad of cancer therapeutics: insights from WNT signaling & flavonoids

Gupta, Akanksha ; Mehrotra, Arpit ; Sood, Abhilasha ; Sharma, Bunty ; Yadav, Vikas LU orcid ; Kaur, Ginpreet ; Sak, Katrin ; Satapathy, Shakti Ranjan LU and Tuli, Hardeep Singh (2025) In Frontiers in Molecular Biosciences 12. p.01-14
Abstract
MicroRNAs (miRNAs) are pivotal post-transcriptional regulators that orchestrate gene expression programs governing cancer initiation, progression, metastasis, and therapeutic resistance. Among their many targets, the WNT signaling pathway, a key driver of malignancy, is tightly controlled by miRNAs, forming intricate feedback loops that shape tumor behavior. Concurrently, flavonoids, naturally occurring plant-derived polyphenols, are emerging as promising anticancer agents that can modulate both WNT signaling and miRNA expression. This review highlights miRNAs as the central regulators of oncogenic signaling, focusing on their dualistic role in cancer biology and their modulation by flavonoids. We explore the mechanistic frameworks... (More)
MicroRNAs (miRNAs) are pivotal post-transcriptional regulators that orchestrate gene expression programs governing cancer initiation, progression, metastasis, and therapeutic resistance. Among their many targets, the WNT signaling pathway, a key driver of malignancy, is tightly controlled by miRNAs, forming intricate feedback loops that shape tumor behavior. Concurrently, flavonoids, naturally occurring plant-derived polyphenols, are emerging as promising anticancer agents that can modulate both WNT signaling and miRNA expression. This review highlights miRNAs as the central regulators of oncogenic signaling, focusing on their dualistic role in cancer biology and their modulation by flavonoids. We explore the mechanistic frameworks underpinning miRNA-WNT interactions and the therapeutic potential of flavonoid-mediated miRNA reprogramming for precision miRNA targeting. Unraveling this regulatory axis offers a promising avenue for developing multi-targeted therapies and personalized cancer treatment strategies. (Less)
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Frontiers in Molecular Biosciences
volume
12
article number
1616221
pages
01 - 14
publisher
Frontiers Media S. A.
external identifiers
  • pmid:40874062
  • scopus:105014497094
ISSN
2296-889X
DOI
10.3389/fmolb.2025.1616221
language
English
LU publication?
yes
id
24fd7963-9342-41bb-9726-6f5e6b3a8af2
date added to LUP
2025-10-16 22:28:12
date last changed
2025-10-18 03:42:01
@article{24fd7963-9342-41bb-9726-6f5e6b3a8af2,
  abstract     = {{MicroRNAs (miRNAs) are pivotal post-transcriptional regulators that orchestrate gene expression programs governing cancer initiation, progression, metastasis, and therapeutic resistance. Among their many targets, the WNT signaling pathway, a key driver of malignancy, is tightly controlled by miRNAs, forming intricate feedback loops that shape tumor behavior. Concurrently, flavonoids, naturally occurring plant-derived polyphenols, are emerging as promising anticancer agents that can modulate both WNT signaling and miRNA expression. This review highlights miRNAs as the central regulators of oncogenic signaling, focusing on their dualistic role in cancer biology and their modulation by flavonoids. We explore the mechanistic frameworks underpinning miRNA-WNT interactions and the therapeutic potential of flavonoid-mediated miRNA reprogramming for precision miRNA targeting. Unraveling this regulatory axis offers a promising avenue for developing multi-targeted therapies and personalized cancer treatment strategies.}},
  author       = {{Gupta, Akanksha and Mehrotra, Arpit and Sood, Abhilasha and Sharma, Bunty and Yadav, Vikas and Kaur, Ginpreet and Sak, Katrin and Satapathy, Shakti Ranjan and Tuli, Hardeep Singh}},
  issn         = {{2296-889X}},
  language     = {{eng}},
  month        = {{08}},
  pages        = {{01--14}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Molecular Biosciences}},
  title        = {{MicroRNAs at the crossroad of cancer therapeutics: insights from WNT signaling & flavonoids}},
  url          = {{http://dx.doi.org/10.3389/fmolb.2025.1616221}},
  doi          = {{10.3389/fmolb.2025.1616221}},
  volume       = {{12}},
  year         = {{2025}},
}