OARSI/OMERACT Criteria of Being Considered a Candidate for Total Joint Replacement in Knee/Hip Osteoarthritis as an Endpoint in Clinical Trials Evaluating Potential Disease Modifying Osteoarthritic Drugs
Dougados, Maxime ; Hawker, Gillian ; Lohmander, Stefan LU
; Davis, Aileen M.
; Dieppe, Paul
; Maillefert, Jean-Francis
and Gossec, Laure
(2009)
9th International Consensus Conference on Outcome Measures in Rheumatology Clinical Trails (OMERACT 9)
36(9).
p.2097-2099
- Abstract
- Objective. A disease-modifying osteoarthritic drug (DMOAD) should interfere with the cartilage breakdown observed and improve symptoms or prevent deterioration of the patient's clinical condition. We propose a composite index including structural and symptomatic variables of osteoarthritis (OA) as criteria for being considered a candidate for total joint replacement as an endpoint in clinical trials evaluating potential DMOAD. Methods. An OARSI/OMERACT task force conducted this study in 3 steps: (1) The 3 main domains - pain, function, structure - were revisited; (2) For each of the domains a "non-acceptable state" and a "relevant" progression for their structure were defined; and (3) a set of criteria was proposed combining the... (More)
- Objective. A disease-modifying osteoarthritic drug (DMOAD) should interfere with the cartilage breakdown observed and improve symptoms or prevent deterioration of the patient's clinical condition. We propose a composite index including structural and symptomatic variables of osteoarthritis (OA) as criteria for being considered a candidate for total joint replacement as an endpoint in clinical trials evaluating potential DMOAD. Methods. An OARSI/OMERACT task force conducted this study in 3 steps: (1) The 3 main domains - pain, function, structure - were revisited; (2) For each of the domains a "non-acceptable state" and a "relevant" progression for their structure were defined; and (3) a set of criteria was proposed combining the information from these 3 domains. Results. A questionnaire was elaborated for the domains "pain" and "function." Systematic research of the literature and evaluation of different databases concluded that the domain "structure" should be evaluated by radiological joint space width in millimeters. An unacceptable radiographic progression was defined as a change in the joint space width over the measurement error. An international, cross-sectional study is proposing a definition of a "nonacceptable symptom state." Conclusion. The objective of the ongoing OARSI/OMERACT initiative is to propose criteria for being considered a candidate for total joint replacement to be used as an endpoint in clinical trials evaluating potential DMOAD. The preliminary steps of this initiative have been completed. (J Rheumatol 2009;36:2097-9; doi:10.3899/jrheum.090365) (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1492301
- author
- Dougados, Maxime
; Hawker, Gillian
; Lohmander, Stefan
LU
; Davis, Aileen M.
; Dieppe, Paul
; Maillefert, Jean-Francis
and Gossec, Laure
- organization
- publishing date
- 2009
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- ANTI-OSTEOARTHRITIC DRUGS, OSTEOARTHRITIS, TOTAL JOINT REPLACEMENT
- host publication
- Journal of Rheumatology
- volume
- 36
- issue
- 9
- pages
- 2097 - 2099
- publisher
- Journal of Rheumatology Publishing Company Limited
- conference name
- 9th International Consensus Conference on Outcome Measures in Rheumatology Clinical Trails (OMERACT 9)
- conference location
- Kananaskis, Canada
- conference dates
- 2008-05-27 - 2008-05-31
- external identifiers
-
- wos:000269677600045
- scopus:70349259391
- ISSN
- 1499-2752
- 0315-162X
- DOI
- 10.3899/jrheum.090365
- language
- English
- LU publication?
- yes
- id
- 2508f624-e548-4758-b7c4-a30ba85bd746 (old id 1492301)
- date added to LUP
- 2016-04-01 11:54:15
- date last changed
- 2024-04-08 17:38:26
@inproceedings{2508f624-e548-4758-b7c4-a30ba85bd746,
abstract = {{Objective. A disease-modifying osteoarthritic drug (DMOAD) should interfere with the cartilage breakdown observed and improve symptoms or prevent deterioration of the patient's clinical condition. We propose a composite index including structural and symptomatic variables of osteoarthritis (OA) as criteria for being considered a candidate for total joint replacement as an endpoint in clinical trials evaluating potential DMOAD. Methods. An OARSI/OMERACT task force conducted this study in 3 steps: (1) The 3 main domains - pain, function, structure - were revisited; (2) For each of the domains a "non-acceptable state" and a "relevant" progression for their structure were defined; and (3) a set of criteria was proposed combining the information from these 3 domains. Results. A questionnaire was elaborated for the domains "pain" and "function." Systematic research of the literature and evaluation of different databases concluded that the domain "structure" should be evaluated by radiological joint space width in millimeters. An unacceptable radiographic progression was defined as a change in the joint space width over the measurement error. An international, cross-sectional study is proposing a definition of a "nonacceptable symptom state." Conclusion. The objective of the ongoing OARSI/OMERACT initiative is to propose criteria for being considered a candidate for total joint replacement to be used as an endpoint in clinical trials evaluating potential DMOAD. The preliminary steps of this initiative have been completed. (J Rheumatol 2009;36:2097-9; doi:10.3899/jrheum.090365)}},
author = {{Dougados, Maxime and Hawker, Gillian and Lohmander, Stefan and Davis, Aileen M. and Dieppe, Paul and Maillefert, Jean-Francis and Gossec, Laure}},
booktitle = {{Journal of Rheumatology}},
issn = {{1499-2752}},
keywords = {{ANTI-OSTEOARTHRITIC DRUGS; OSTEOARTHRITIS; TOTAL JOINT REPLACEMENT}},
language = {{eng}},
number = {{9}},
pages = {{2097--2099}},
publisher = {{Journal of Rheumatology Publishing Company Limited}},
title = {{OARSI/OMERACT Criteria of Being Considered a Candidate for Total Joint Replacement in Knee/Hip Osteoarthritis as an Endpoint in Clinical Trials Evaluating Potential Disease Modifying Osteoarthritic Drugs}},
url = {{http://dx.doi.org/10.3899/jrheum.090365}},
doi = {{10.3899/jrheum.090365}},
volume = {{36}},
year = {{2009}},
}