Cell transplantation in Parkinson's disease: how can we make it work?
Winkler, C ; Kirik, Deniz LU and Björklund, Anders LU
(2005)
In Trends in Neurosciences
28(2).
p.86-92
- Abstract
- Previous open-label clinical trials have provided proof of principle that intrastriatal transplants of fetal dopaminergic neurons can induce substantial and long-lasting functional benefits in patients with Parkinson's disease. However, in two recent NIH-sponsored double-blind trials, functional improvements were only marginal and the primary endpoints were not met. Severe off-phase dyskinesias were observed in a significant proportion of the transplanted patients, raising doubts about the viability of the cell-transplantation approach. Here, we discuss the problems raised by the NIH-sponsored trials and point to several shortcomings that might explain the overall poor outcome, and we identify several crucial issues that remain to be... (More)
- Previous open-label clinical trials have provided proof of principle that intrastriatal transplants of fetal dopaminergic neurons can induce substantial and long-lasting functional benefits in patients with Parkinson's disease. However, in two recent NIH-sponsored double-blind trials, functional improvements were only marginal and the primary endpoints were not met. Severe off-phase dyskinesias were observed in a significant proportion of the transplanted patients, raising doubts about the viability of the cell-transplantation approach. Here, we discuss the problems raised by the NIH-sponsored trials and point to several shortcomings that might explain the overall poor outcome, and we identify several crucial issues that remain to be resolved to develop cell replacement into an effective and safe therapy. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/251028
- author
- Winkler, C
; Kirik, Deniz
LU
and Björklund, Anders
LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Trends in Neurosciences
- volume
- 28
- issue
- 2
- pages
- 86 - 92
- publisher
- Elsevier
- external identifiers
-
- wos:000227225600008
- scopus:13144259693
- ISSN
- 1878-108X
- DOI
- 10.1016/j.tins.2004.12.006
- language
- English
- LU publication?
- yes
- id
- a7bdc15d-b15f-4273-9a7d-22a0b2f34de2 (old id 251028)
- date added to LUP
- 2016-04-01 17:03:20
- date last changed
- 2022-02-20 18:15:49
@misc{a7bdc15d-b15f-4273-9a7d-22a0b2f34de2,
abstract = {{Previous open-label clinical trials have provided proof of principle that intrastriatal transplants of fetal dopaminergic neurons can induce substantial and long-lasting functional benefits in patients with Parkinson's disease. However, in two recent NIH-sponsored double-blind trials, functional improvements were only marginal and the primary endpoints were not met. Severe off-phase dyskinesias were observed in a significant proportion of the transplanted patients, raising doubts about the viability of the cell-transplantation approach. Here, we discuss the problems raised by the NIH-sponsored trials and point to several shortcomings that might explain the overall poor outcome, and we identify several crucial issues that remain to be resolved to develop cell replacement into an effective and safe therapy.}},
author = {{Winkler, C and Kirik, Deniz and Björklund, Anders}},
issn = {{1878-108X}},
language = {{eng}},
number = {{2}},
pages = {{86--92}},
publisher = {{Elsevier}},
series = {{Trends in Neurosciences}},
title = {{Cell transplantation in Parkinson's disease: how can we make it work?}},
url = {{http://dx.doi.org/10.1016/j.tins.2004.12.006}},
doi = {{10.1016/j.tins.2004.12.006}},
volume = {{28}},
year = {{2005}},
}