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Morphometric Differences between the Medial and Lateral Meniscus in Healthy Men - A Three-Dimensional Analysis Using Magnetic Resonance Imaging

Bloecker, K.; Wirth, W.; Hudelmaier, M.; Burgkart, R.; Frobell, Richard LU and Eckstein, F. (2012) In Cells Tissues Organs 195(4). p.353-364
Abstract
The objective of this work was to characterize tibial plateau coverage and morphometric differences of the medial (MM) and lateral meniscus (LM) in a male reference cohort using three-dimensional imaging. Coronal multiplanar reconstructions of a sagittal double-echo steady state with water excitation magnetic resonance sequence (slice thickness: 1.5 mm, and in-plane resolution: 0.37 x 0.70 mm) were analyzed in 47 male participants without symptoms, signs or risk factors of knee osteoarthritis of the reference cohort of the Osteoarthritis Initiative. The medial and lateral tibial (LT) plateau cartilage area and the tibial, femoral and external surfaces of the MM and LM were manually segmented throughout the entire knee. This process was... (More)
The objective of this work was to characterize tibial plateau coverage and morphometric differences of the medial (MM) and lateral meniscus (LM) in a male reference cohort using three-dimensional imaging. Coronal multiplanar reconstructions of a sagittal double-echo steady state with water excitation magnetic resonance sequence (slice thickness: 1.5 mm, and in-plane resolution: 0.37 x 0.70 mm) were analyzed in 47 male participants without symptoms, signs or risk factors of knee osteoarthritis of the reference cohort of the Osteoarthritis Initiative. The medial and lateral tibial (LT) plateau cartilage area and the tibial, femoral and external surfaces of the MM and LM were manually segmented throughout the entire knee. This process was assisted by parallel inspection of a coronal intermediately weighted turbo spin echo sequence. Measures of tibial coverage, meniscus size, and meniscus position were computed three-dimensionally for the total menisci, the body, and the anterior and the posterior horn. The LM was found to cover a significantly greater (p < 0.001) proportion of the LT plateau (59 +/- 6.8%) than the MM of the medial plateau (50 +/- 5.5%). Whereas the volume of both menisci was similar (2.444 vs. 2.438 ml; p = 0.92), the LM displayed larger tibial and femoral surface areas (p < 0.05) and a smaller maximal (7.2 +/- 1.0 vs. 7.7 +/- 1.1 mm; p < 0.01) and mean thickness (2.7 +/- 0.3 vs. 2.8 +/- 0.3 mm; p < 0.001) than the medial one. Also, the LM displayed less (physiological) extrusion than the medial one. These data may guide strategies for meniscal tissue engineering and transplantation aiming to restore normal joint conditions. Copyright 2011 (C) S. Karger AG, Basel (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Knee joint, Magnetic resonance imaging, Meniscus, Morphometry
in
Cells Tissues Organs
volume
195
issue
4
pages
353 - 364
publisher
Karger
external identifiers
  • wos:000301766000007
  • scopus:84859008845
ISSN
1422-6405
DOI
10.1159/000327012
language
English
LU publication?
yes
id
aec92dac-85b5-422c-a210-980150e94a0a (old id 2515316)
date added to LUP
2012-05-07 12:31:54
date last changed
2017-05-07 03:45:42
@article{aec92dac-85b5-422c-a210-980150e94a0a,
  abstract     = {The objective of this work was to characterize tibial plateau coverage and morphometric differences of the medial (MM) and lateral meniscus (LM) in a male reference cohort using three-dimensional imaging. Coronal multiplanar reconstructions of a sagittal double-echo steady state with water excitation magnetic resonance sequence (slice thickness: 1.5 mm, and in-plane resolution: 0.37 x 0.70 mm) were analyzed in 47 male participants without symptoms, signs or risk factors of knee osteoarthritis of the reference cohort of the Osteoarthritis Initiative. The medial and lateral tibial (LT) plateau cartilage area and the tibial, femoral and external surfaces of the MM and LM were manually segmented throughout the entire knee. This process was assisted by parallel inspection of a coronal intermediately weighted turbo spin echo sequence. Measures of tibial coverage, meniscus size, and meniscus position were computed three-dimensionally for the total menisci, the body, and the anterior and the posterior horn. The LM was found to cover a significantly greater (p &lt; 0.001) proportion of the LT plateau (59 +/- 6.8%) than the MM of the medial plateau (50 +/- 5.5%). Whereas the volume of both menisci was similar (2.444 vs. 2.438 ml; p = 0.92), the LM displayed larger tibial and femoral surface areas (p &lt; 0.05) and a smaller maximal (7.2 +/- 1.0 vs. 7.7 +/- 1.1 mm; p &lt; 0.01) and mean thickness (2.7 +/- 0.3 vs. 2.8 +/- 0.3 mm; p &lt; 0.001) than the medial one. Also, the LM displayed less (physiological) extrusion than the medial one. These data may guide strategies for meniscal tissue engineering and transplantation aiming to restore normal joint conditions. Copyright 2011 (C) S. Karger AG, Basel},
  author       = {Bloecker, K. and Wirth, W. and Hudelmaier, M. and Burgkart, R. and Frobell, Richard and Eckstein, F.},
  issn         = {1422-6405},
  keyword      = {Knee joint,Magnetic resonance imaging,Meniscus,Morphometry},
  language     = {eng},
  number       = {4},
  pages        = {353--364},
  publisher    = {Karger},
  series       = {Cells Tissues Organs},
  title        = {Morphometric Differences between the Medial and Lateral Meniscus in Healthy Men - A Three-Dimensional Analysis Using Magnetic Resonance Imaging},
  url          = {http://dx.doi.org/10.1159/000327012},
  volume       = {195},
  year         = {2012},
}