Advanced

Quantitative Cherenkov emission spectroscopy for tissue oxygenation assessment

Axelsson, Johan LU ; Glaser, Adam K.; Gladstone, David J. and Pogue, Brian W. (2012) In Optics Express 20(5). p.5133-5142
Abstract
Measurements of Cherenkov emission in tissue during radiation therapy are shown to enable estimation of hemoglobin oxygen saturation non-invasively, through spectral fitting of the spontaneous emissions from the treated tissue. Tissue oxygenation plays a critical role in the efficacy of radiation therapy to kill tumor tissue. Yet in-vivo measurement of this has remained elusive in routine use because of the complexity of oxygen measurement techniques. There is a spectrally broad emission of Cherenkov light that is induced during the time of irradiation, and as this travels through tissue from the point of the radiation deposition, the tissue absorption and scatter impart spectral changes. These changes can be quantified by diffuse spectral... (More)
Measurements of Cherenkov emission in tissue during radiation therapy are shown to enable estimation of hemoglobin oxygen saturation non-invasively, through spectral fitting of the spontaneous emissions from the treated tissue. Tissue oxygenation plays a critical role in the efficacy of radiation therapy to kill tumor tissue. Yet in-vivo measurement of this has remained elusive in routine use because of the complexity of oxygen measurement techniques. There is a spectrally broad emission of Cherenkov light that is induced during the time of irradiation, and as this travels through tissue from the point of the radiation deposition, the tissue absorption and scatter impart spectral changes. These changes can be quantified by diffuse spectral fitting of the signal. Thus Cherenkov emission spectroscopy is demonstrated for the first time quantitatively in vitro and qualitatively in vivo, and has potential for real-time online tracking of tissue oxygen during radiation therapy when fully characterized and developed. (C) 2012 Optical Society of America (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Optics Express
volume
20
issue
5
pages
5133 - 5142
publisher
OSA
external identifiers
  • wos:000301053200033
  • scopus:84857525455
ISSN
1094-4087
DOI
10.1364/OE.20.005133
language
English
LU publication?
yes
id
a81f7d99-fbbb-4dd3-92ae-9c47e4fb271f (old id 2517334)
date added to LUP
2012-05-09 09:49:31
date last changed
2017-08-27 04:31:42
@article{a81f7d99-fbbb-4dd3-92ae-9c47e4fb271f,
  abstract     = {Measurements of Cherenkov emission in tissue during radiation therapy are shown to enable estimation of hemoglobin oxygen saturation non-invasively, through spectral fitting of the spontaneous emissions from the treated tissue. Tissue oxygenation plays a critical role in the efficacy of radiation therapy to kill tumor tissue. Yet in-vivo measurement of this has remained elusive in routine use because of the complexity of oxygen measurement techniques. There is a spectrally broad emission of Cherenkov light that is induced during the time of irradiation, and as this travels through tissue from the point of the radiation deposition, the tissue absorption and scatter impart spectral changes. These changes can be quantified by diffuse spectral fitting of the signal. Thus Cherenkov emission spectroscopy is demonstrated for the first time quantitatively in vitro and qualitatively in vivo, and has potential for real-time online tracking of tissue oxygen during radiation therapy when fully characterized and developed. (C) 2012 Optical Society of America},
  author       = {Axelsson, Johan and Glaser, Adam K. and Gladstone, David J. and Pogue, Brian W.},
  issn         = {1094-4087},
  language     = {eng},
  number       = {5},
  pages        = {5133--5142},
  publisher    = {OSA},
  series       = {Optics Express},
  title        = {Quantitative Cherenkov emission spectroscopy for tissue oxygenation assessment},
  url          = {http://dx.doi.org/10.1364/OE.20.005133},
  volume       = {20},
  year         = {2012},
}