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Infection intensity and infectivity of the tick-borne pathogen Borrelia afzelii.

Råberg, Lars LU (2012) In Journal of Evolutionary Biology 25(7). p.1448-1453
Abstract
The 'trade-off' hypothesis for virulence evolution assumes that between-host transmission rate is a positive and saturating function of pathogen exploitation and virulence, but there are as yet few tests of this assumption, in particular for vector-borne pathogens. Here, I show that the infectivity (probability of transmission) of the tick-borne bacterium Borrelia afzelii from two of its natural rodent hosts (bank vole and yellow-necked mouse) to its main tick vector increases asymptotically with increasing exploitation (measured as bacterial load in skin biopsies). Hence, this result provides support for one of the basic assumptions of the 'trade-off hypothesis'. Moreover, there was no difference in infectivity between bank voles and... (More)
The 'trade-off' hypothesis for virulence evolution assumes that between-host transmission rate is a positive and saturating function of pathogen exploitation and virulence, but there are as yet few tests of this assumption, in particular for vector-borne pathogens. Here, I show that the infectivity (probability of transmission) of the tick-borne bacterium Borrelia afzelii from two of its natural rodent hosts (bank vole and yellow-necked mouse) to its main tick vector increases asymptotically with increasing exploitation (measured as bacterial load in skin biopsies). Hence, this result provides support for one of the basic assumptions of the 'trade-off hypothesis'. Moreover, there was no difference in infectivity between bank voles and yellow-necked mice despite bacterial loads being on average an order of magnitude higher in bank voles, most likely because ticks took larger blood meals from mice. This shows that interspecific variation in host resistance does not necessarily translate into a difference in infectivity. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Borrelia, host–parasite interactions, Lyme borreliosis, virulence, zoonotic disease
in
Journal of Evolutionary Biology
volume
25
issue
7
pages
1448 - 1453
publisher
John Wiley & Sons
external identifiers
  • wos:000305130800020
  • pmid:22536945
  • scopus:84862261016
ISSN
1420-9101
DOI
10.1111/j.1420-9101.2012.02515.x
project
Borrelia in rodents
language
English
LU publication?
yes
id
b6c255a6-236e-40f3-a8e5-1d2c9d158a58 (old id 2518977)
date added to LUP
2012-05-08 11:30:23
date last changed
2017-05-28 03:19:49
@article{b6c255a6-236e-40f3-a8e5-1d2c9d158a58,
  abstract     = {The 'trade-off' hypothesis for virulence evolution assumes that between-host transmission rate is a positive and saturating function of pathogen exploitation and virulence, but there are as yet few tests of this assumption, in particular for vector-borne pathogens. Here, I show that the infectivity (probability of transmission) of the tick-borne bacterium Borrelia afzelii from two of its natural rodent hosts (bank vole and yellow-necked mouse) to its main tick vector increases asymptotically with increasing exploitation (measured as bacterial load in skin biopsies). Hence, this result provides support for one of the basic assumptions of the 'trade-off hypothesis'. Moreover, there was no difference in infectivity between bank voles and yellow-necked mice despite bacterial loads being on average an order of magnitude higher in bank voles, most likely because ticks took larger blood meals from mice. This shows that interspecific variation in host resistance does not necessarily translate into a difference in infectivity.},
  author       = {Råberg, Lars},
  issn         = {1420-9101},
  keyword      = {Borrelia,host–parasite interactions,Lyme borreliosis,virulence,zoonotic disease},
  language     = {eng},
  number       = {7},
  pages        = {1448--1453},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Evolutionary Biology},
  title        = {Infection intensity and infectivity of the tick-borne pathogen Borrelia afzelii.},
  url          = {http://dx.doi.org/10.1111/j.1420-9101.2012.02515.x},
  volume       = {25},
  year         = {2012},
}