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Metabolic risk factors and skin cancer in the Metabolic Syndrome and Cancer Project (Me-Can).

Nagel, G; Bjørge, T; Stocks, T; Manjer, Jonas LU ; Hallmans, G; Edlinger, M; Häggström, C; Engeland, A; Johansen, Dorthe LU and Kleiner, A, et al. (2012) In British Journal of Dermatology 167(1). p.59-67
Abstract
Background: Little is known about the associations of metabolic aberrations with malignant melanoma (MM) and nonmelanoma skin cancer (NMSC).



Objectives: To assess the associations between metabolic factors (both individually and combined) and the risk of skin cancer in the large prospective Metabolic Syndrome and Cancer Project (Me-Can).



Methods: During a mean follow-up of 12 years of the Me-Can cohort, 1728 (41% women) incident MM, 230 (23% women) fatal MM and 1145 (33% women) NMSC were identified. Most NMSC cases (76%) were squamous cell carcinoma (SCC) (873, 33% women). Hazard ratios (HRs) were estimated by Cox proportional hazards regression for quintiles and standardized z-scores (with a mean of... (More)
Background: Little is known about the associations of metabolic aberrations with malignant melanoma (MM) and nonmelanoma skin cancer (NMSC).



Objectives: To assess the associations between metabolic factors (both individually and combined) and the risk of skin cancer in the large prospective Metabolic Syndrome and Cancer Project (Me-Can).



Methods: During a mean follow-up of 12 years of the Me-Can cohort, 1728 (41% women) incident MM, 230 (23% women) fatal MM and 1145 (33% women) NMSC were identified. Most NMSC cases (76%) were squamous cell carcinoma (SCC) (873, 33% women). Hazard ratios (HRs) were estimated by Cox proportional hazards regression for quintiles and standardized z-scores (with a mean of 0 and SD of 1) of body mass index (BMI), blood pressure, glucose, cholesterol, triglycerides and for a combined metabolic syndrome score. Risk estimates were corrected for random error in the measurements.



Results: Blood pressure per unit increase of z-score was associated with an increased risk of incident MM cases in men and women [HR 1·17, 95% confidence interval (CI) 1·04-1·31 and HR 1·18, 95% CI 1·03-1·36, respectively] and fatal MM cases among women (HR 2·39, 95% CI 1·58-3·64). In men, all quintiles for BMI above the reference were associated with a higher risk of incident MM. In women, SCC NMSC risk increased across quintiles for glucose levels (P-trend 0·02) and there was a trend with triglyceride concentration (P-trend 0·09).



Conclusion: These findings suggest that mechanisms linked to blood pressure may be involved in the pathogenesis of MM. SCC NMSC in women could be related to glucose and lipid metabolism. (Less)
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Contribution to journal
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British Journal of Dermatology
volume
167
issue
1
pages
59 - 67
publisher
Wiley-Blackwell
external identifiers
  • wos:000305791500012
  • pmid:22530854
  • scopus:84863318076
ISSN
1365-2133
DOI
10.1111/j.1365-2133.2012.10974.x
language
English
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yes
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d25f1a1e-aae4-4e78-ae7f-931eadcc6d73 (old id 2519097)
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http://www.ncbi.nlm.nih.gov/pubmed/22530854?dopt=Abstract
date added to LUP
2012-05-06 20:07:42
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2017-01-22 04:15:28
@article{d25f1a1e-aae4-4e78-ae7f-931eadcc6d73,
  abstract     = {Background: Little is known about the associations of metabolic aberrations with malignant melanoma (MM) and nonmelanoma skin cancer (NMSC). <br/><br>
<br/><br>
Objectives: To assess the associations between metabolic factors (both individually and combined) and the risk of skin cancer in the large prospective Metabolic Syndrome and Cancer Project (Me-Can). <br/><br>
<br/><br>
Methods: During a mean follow-up of 12 years of the Me-Can cohort, 1728 (41% women) incident MM, 230 (23% women) fatal MM and 1145 (33% women) NMSC were identified. Most NMSC cases (76%) were squamous cell carcinoma (SCC) (873, 33% women). Hazard ratios (HRs) were estimated by Cox proportional hazards regression for quintiles and standardized z-scores (with a mean of 0 and SD of 1) of body mass index (BMI), blood pressure, glucose, cholesterol, triglycerides and for a combined metabolic syndrome score. Risk estimates were corrected for random error in the measurements. <br/><br>
<br/><br>
Results: Blood pressure per unit increase of z-score was associated with an increased risk of incident MM cases in men and women [HR 1·17, 95% confidence interval (CI) 1·04-1·31 and HR 1·18, 95% CI 1·03-1·36, respectively] and fatal MM cases among women (HR 2·39, 95% CI 1·58-3·64). In men, all quintiles for BMI above the reference were associated with a higher risk of incident MM. In women, SCC NMSC risk increased across quintiles for glucose levels (P-trend 0·02) and there was a trend with triglyceride concentration (P-trend 0·09). <br/><br>
<br/><br>
Conclusion: These findings suggest that mechanisms linked to blood pressure may be involved in the pathogenesis of MM. SCC NMSC in women could be related to glucose and lipid metabolism.},
  author       = {Nagel, G and Bjørge, T and Stocks, T and Manjer, Jonas and Hallmans, G and Edlinger, M and Häggström, C and Engeland, A and Johansen, Dorthe and Kleiner, A and Selmer, R and Ulmer, H and Tretli, S and Jonsson, H and Concin, H and Stattin, P and Lukanova, A},
  issn         = {1365-2133},
  language     = {eng},
  number       = {1},
  pages        = {59--67},
  publisher    = {Wiley-Blackwell},
  series       = {British Journal of Dermatology},
  title        = {Metabolic risk factors and skin cancer in the Metabolic Syndrome and Cancer Project (Me-Can).},
  url          = {http://dx.doi.org/10.1111/j.1365-2133.2012.10974.x},
  volume       = {167},
  year         = {2012},
}