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Factors associated with changes in quality of life in patients undergoing allogeneic haematopoietic stem cell transplantation.

Kisch, A; Lenhoff, Stig LU ; Zdravkovic, S and Bolmsjö, I (2012) In European Journal of Cancer Care
Abstract
It is well known that patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT) experience changes in quality of life. We investigated factors associated with quality of life changes in adult HSCT patients. The Functional Assessment of Cancer Therapy - Bone Marrow Transplantation (FACT-BMT) scale, supplemented with the Functional Assessment of Chronic Illness Therapy - Spiritual Well-being (FACIT-Sp) subscale, was administered on three occasions, immediately before transplantation, 100 days and 12 months after transplantation. Analyses of nine selected factors were made where changes in quality of life were found. Seventy-five patients were included and 40 of these completed the study. Emotional well-being was found to... (More)
It is well known that patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT) experience changes in quality of life. We investigated factors associated with quality of life changes in adult HSCT patients. The Functional Assessment of Cancer Therapy - Bone Marrow Transplantation (FACT-BMT) scale, supplemented with the Functional Assessment of Chronic Illness Therapy - Spiritual Well-being (FACIT-Sp) subscale, was administered on three occasions, immediately before transplantation, 100 days and 12 months after transplantation. Analyses of nine selected factors were made where changes in quality of life were found. Seventy-five patients were included and 40 of these completed the study. Emotional well-being was found to improve between the baseline and 100 days, while all other dimensions deteriorated, including overall quality of life. Physical and social/family well-being deteriorated between the baseline and the 12-month follow-up, while emotional well-being improved. The main factors associated with deteriorating quality of life over time were found to be significant infections, female gender and transplantation with stem cells from a sibling donor. In our further studies we aim to focus on the relationships between patients and sibling donors in order to improve the care. Careful attention must be paid to continuous adequate information during the transplantation procedure. (Less)
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type
Contribution to journal
publication status
published
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in
European Journal of Cancer Care
publisher
John Wiley & Sons
external identifiers
  • wos:000314038700006
  • pmid:22519415
  • scopus:84867904924
ISSN
1365-2354
DOI
10.1111/j.1365-2354.2012.01354.x
language
English
LU publication?
yes
id
e7383169-c5b8-4681-a37a-3b315e3b71c7 (old id 2519261)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22519415?dopt=Abstract
date added to LUP
2012-05-06 19:42:44
date last changed
2017-01-01 07:35:42
@article{e7383169-c5b8-4681-a37a-3b315e3b71c7,
  abstract     = {It is well known that patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT) experience changes in quality of life. We investigated factors associated with quality of life changes in adult HSCT patients. The Functional Assessment of Cancer Therapy - Bone Marrow Transplantation (FACT-BMT) scale, supplemented with the Functional Assessment of Chronic Illness Therapy - Spiritual Well-being (FACIT-Sp) subscale, was administered on three occasions, immediately before transplantation, 100 days and 12 months after transplantation. Analyses of nine selected factors were made where changes in quality of life were found. Seventy-five patients were included and 40 of these completed the study. Emotional well-being was found to improve between the baseline and 100 days, while all other dimensions deteriorated, including overall quality of life. Physical and social/family well-being deteriorated between the baseline and the 12-month follow-up, while emotional well-being improved. The main factors associated with deteriorating quality of life over time were found to be significant infections, female gender and transplantation with stem cells from a sibling donor. In our further studies we aim to focus on the relationships between patients and sibling donors in order to improve the care. Careful attention must be paid to continuous adequate information during the transplantation procedure.},
  author       = {Kisch, A and Lenhoff, Stig and Zdravkovic, S and Bolmsjö, I},
  issn         = {1365-2354},
  language     = {eng},
  month        = {04},
  publisher    = {John Wiley & Sons},
  series       = {European Journal of Cancer Care},
  title        = {Factors associated with changes in quality of life in patients undergoing allogeneic haematopoietic stem cell transplantation.},
  url          = {http://dx.doi.org/10.1111/j.1365-2354.2012.01354.x},
  year         = {2012},
}