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Contribution of catalase to hydrogen peroxide resistance in Enterococcus faecalis.

Baureder, Michael LU ; Reimann, Ronny and Hederstedt, Lars LU (2012) In FEMS Microbiology Letters 331(2). p.160-164
Abstract
Enterococcus faecalis exhibits high resistance to oxidative stress. Several enzymes are responsible for this trait. The role of alkyl hydroperoxide reductase (Ahp), thiol peroxidase (Tpx), and NADH peroxidase (Npr) in oxidative stress defense was recently characterized. Enterococcus faecalis, in contrast to many other streptococci, contains a catalase (KatA), but this enzyme can only be formed when the bacterium is supplied with heme. We have used this heme dependency of catalase activity and mutants deficient in KatA and Npr to investigate the role of the catalase in resistance against exogenous and endogenous hydrogen peroxide stress. The results demonstrate that in the presence of environmental heme catalase contributes to the... (More)
Enterococcus faecalis exhibits high resistance to oxidative stress. Several enzymes are responsible for this trait. The role of alkyl hydroperoxide reductase (Ahp), thiol peroxidase (Tpx), and NADH peroxidase (Npr) in oxidative stress defense was recently characterized. Enterococcus faecalis, in contrast to many other streptococci, contains a catalase (KatA), but this enzyme can only be formed when the bacterium is supplied with heme. We have used this heme dependency of catalase activity and mutants deficient in KatA and Npr to investigate the role of the catalase in resistance against exogenous and endogenous hydrogen peroxide stress. The results demonstrate that in the presence of environmental heme catalase contributes to the protection against toxic effects of hydrogen peroxide. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
oxidative stress, heme, NADH peroxidase, streptococci
in
FEMS Microbiology Letters
volume
331
issue
2
pages
160 - 164
publisher
Elsevier
external identifiers
  • wos:000304187800010
  • pmid:22486165
  • scopus:84861232907
ISSN
1574-6968
DOI
10.1111/j.1574-6968.2012.02567.x
language
English
LU publication?
yes
id
478e9de3-fa18-40df-85fd-def12a729bac (old id 2519694)
date added to LUP
2012-05-08 11:38:48
date last changed
2017-11-19 03:58:18
@article{478e9de3-fa18-40df-85fd-def12a729bac,
  abstract     = {Enterococcus faecalis exhibits high resistance to oxidative stress. Several enzymes are responsible for this trait. The role of alkyl hydroperoxide reductase (Ahp), thiol peroxidase (Tpx), and NADH peroxidase (Npr) in oxidative stress defense was recently characterized. Enterococcus faecalis, in contrast to many other streptococci, contains a catalase (KatA), but this enzyme can only be formed when the bacterium is supplied with heme. We have used this heme dependency of catalase activity and mutants deficient in KatA and Npr to investigate the role of the catalase in resistance against exogenous and endogenous hydrogen peroxide stress. The results demonstrate that in the presence of environmental heme catalase contributes to the protection against toxic effects of hydrogen peroxide.},
  author       = {Baureder, Michael and Reimann, Ronny and Hederstedt, Lars},
  issn         = {1574-6968},
  keyword      = {oxidative stress,heme,NADH peroxidase,streptococci},
  language     = {eng},
  number       = {2},
  pages        = {160--164},
  publisher    = {Elsevier},
  series       = {FEMS Microbiology Letters},
  title        = {Contribution of catalase to hydrogen peroxide resistance in <em>Enterococcus faecalis</em>.},
  url          = {http://dx.doi.org/10.1111/j.1574-6968.2012.02567.x},
  volume       = {331},
  year         = {2012},
}