Contribution of catalase to hydrogen peroxide resistance in Enterococcus faecalis.
(2012) In FEMS Microbiology Letters 331(2). p.160-164- Abstract
- Enterococcus faecalis exhibits high resistance to oxidative stress. Several enzymes are responsible for this trait. The role of alkyl hydroperoxide reductase (Ahp), thiol peroxidase (Tpx), and NADH peroxidase (Npr) in oxidative stress defense was recently characterized. Enterococcus faecalis, in contrast to many other streptococci, contains a catalase (KatA), but this enzyme can only be formed when the bacterium is supplied with heme. We have used this heme dependency of catalase activity and mutants deficient in KatA and Npr to investigate the role of the catalase in resistance against exogenous and endogenous hydrogen peroxide stress. The results demonstrate that in the presence of environmental heme catalase contributes to the... (More)
- Enterococcus faecalis exhibits high resistance to oxidative stress. Several enzymes are responsible for this trait. The role of alkyl hydroperoxide reductase (Ahp), thiol peroxidase (Tpx), and NADH peroxidase (Npr) in oxidative stress defense was recently characterized. Enterococcus faecalis, in contrast to many other streptococci, contains a catalase (KatA), but this enzyme can only be formed when the bacterium is supplied with heme. We have used this heme dependency of catalase activity and mutants deficient in KatA and Npr to investigate the role of the catalase in resistance against exogenous and endogenous hydrogen peroxide stress. The results demonstrate that in the presence of environmental heme catalase contributes to the protection against toxic effects of hydrogen peroxide. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2519694
- author
- Baureder, Michael LU ; Reimann, Ronny and Hederstedt, Lars LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- oxidative stress, heme, NADH peroxidase, streptococci
- in
- FEMS Microbiology Letters
- volume
- 331
- issue
- 2
- pages
- 160 - 164
- publisher
- Oxford University Press
- external identifiers
-
- wos:000304187800010
- pmid:22486165
- scopus:84861232907
- pmid:22486165
- ISSN
- 1574-6968
- DOI
- 10.1111/j.1574-6968.2012.02567.x
- language
- English
- LU publication?
- yes
- id
- 478e9de3-fa18-40df-85fd-def12a729bac (old id 2519694)
- date added to LUP
- 2016-04-01 14:38:34
- date last changed
- 2022-03-29 22:08:35
@article{478e9de3-fa18-40df-85fd-def12a729bac,
abstract = {{Enterococcus faecalis exhibits high resistance to oxidative stress. Several enzymes are responsible for this trait. The role of alkyl hydroperoxide reductase (Ahp), thiol peroxidase (Tpx), and NADH peroxidase (Npr) in oxidative stress defense was recently characterized. Enterococcus faecalis, in contrast to many other streptococci, contains a catalase (KatA), but this enzyme can only be formed when the bacterium is supplied with heme. We have used this heme dependency of catalase activity and mutants deficient in KatA and Npr to investigate the role of the catalase in resistance against exogenous and endogenous hydrogen peroxide stress. The results demonstrate that in the presence of environmental heme catalase contributes to the protection against toxic effects of hydrogen peroxide.}},
author = {{Baureder, Michael and Reimann, Ronny and Hederstedt, Lars}},
issn = {{1574-6968}},
keywords = {{oxidative stress; heme; NADH peroxidase; streptococci}},
language = {{eng}},
number = {{2}},
pages = {{160--164}},
publisher = {{Oxford University Press}},
series = {{FEMS Microbiology Letters}},
title = {{Contribution of catalase to hydrogen peroxide resistance in <em>Enterococcus faecalis</em>.}},
url = {{http://dx.doi.org/10.1111/j.1574-6968.2012.02567.x}},
doi = {{10.1111/j.1574-6968.2012.02567.x}},
volume = {{331}},
year = {{2012}},
}