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Prenatal ultrasound detection of cleft lip, or cleft palate, or both, in southern Sweden, 2006-2010.

Berggren, Helena; Hansson, Emma LU ; Uvemark, Annika; Svensson, Henry LU ; Sladkevicius, Povilas LU and Becker, Magnus LU (2012) In Journal of Plastic Surgery and Hand Surgery 46(2). p.69-74
Abstract
It has been possible to detect cleft lip (CL), with or without cleft palate (CLP), using ultrasound (US) since the beginning of the 1980s. The aim of this study was to assess the accuracy of prenatal diagnosis of cleft lip with or without cleft palate, and isolated cleft palate (ICP), in our catchment area. Screening protocols in the different US clinics in southern Sweden were also compared, as regards evaluation of the fetal face and prenatal diagnosis of CLP. Forty-four (31%) of the patients were diagnosed by prenatal US and 97/144 (67%) were diagnosed at birth. The detection rate was 44/102 (43%) if the ICP are excluded. The specificity was 100%. Among the prenatally diagnosed clefts, 25/44 (57%) were diagnosed before the gestational... (More)
It has been possible to detect cleft lip (CL), with or without cleft palate (CLP), using ultrasound (US) since the beginning of the 1980s. The aim of this study was to assess the accuracy of prenatal diagnosis of cleft lip with or without cleft palate, and isolated cleft palate (ICP), in our catchment area. Screening protocols in the different US clinics in southern Sweden were also compared, as regards evaluation of the fetal face and prenatal diagnosis of CLP. Forty-four (31%) of the patients were diagnosed by prenatal US and 97/144 (67%) were diagnosed at birth. The detection rate was 44/102 (43%) if the ICP are excluded. The specificity was 100%. Among the prenatally diagnosed clefts, 25/44 (57%) were diagnosed before the gestational age of 20 weeks. In 19/44 (43%) of the cases the US diagnosis of cleft was accurate in the light of the postnatal outcome. All US departments in our catchment area follow the Swedish guidelines and offer one routine US examination during the second trimester between 18 and 20 weeks of pregnancy. In addition, many of the clinics offer an additional US examination during the third trimester. Our detection rate is similar to previous findings. The detection rates and the accuracy of the prenatal diagnosis can be improved. To achieve this, an increased focus on detecting clefts, standardising scanning plans, and rescans in case of incomplete facial views, are essential. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Plastic Surgery and Hand Surgery
volume
46
issue
2
pages
69 - 74
publisher
Taylor & Francis
external identifiers
  • wos:000302369100003
  • pmid:22471252
  • scopus:84859311980
ISSN
2000-656X
DOI
10.3109/2000656X.2012.668773
language
English
LU publication?
yes
id
667aa04e-128d-44ba-9162-99f9dcb49f2b (old id 2519892)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22471252?dopt=Abstract
date added to LUP
2012-05-04 13:36:33
date last changed
2017-01-01 03:44:35
@article{667aa04e-128d-44ba-9162-99f9dcb49f2b,
  abstract     = {It has been possible to detect cleft lip (CL), with or without cleft palate (CLP), using ultrasound (US) since the beginning of the 1980s. The aim of this study was to assess the accuracy of prenatal diagnosis of cleft lip with or without cleft palate, and isolated cleft palate (ICP), in our catchment area. Screening protocols in the different US clinics in southern Sweden were also compared, as regards evaluation of the fetal face and prenatal diagnosis of CLP. Forty-four (31%) of the patients were diagnosed by prenatal US and 97/144 (67%) were diagnosed at birth. The detection rate was 44/102 (43%) if the ICP are excluded. The specificity was 100%. Among the prenatally diagnosed clefts, 25/44 (57%) were diagnosed before the gestational age of 20 weeks. In 19/44 (43%) of the cases the US diagnosis of cleft was accurate in the light of the postnatal outcome. All US departments in our catchment area follow the Swedish guidelines and offer one routine US examination during the second trimester between 18 and 20 weeks of pregnancy. In addition, many of the clinics offer an additional US examination during the third trimester. Our detection rate is similar to previous findings. The detection rates and the accuracy of the prenatal diagnosis can be improved. To achieve this, an increased focus on detecting clefts, standardising scanning plans, and rescans in case of incomplete facial views, are essential.},
  author       = {Berggren, Helena and Hansson, Emma and Uvemark, Annika and Svensson, Henry and Sladkevicius, Povilas and Becker, Magnus},
  issn         = {2000-656X},
  language     = {eng},
  number       = {2},
  pages        = {69--74},
  publisher    = {Taylor & Francis},
  series       = {Journal of Plastic Surgery and Hand Surgery},
  title        = {Prenatal ultrasound detection of cleft lip, or cleft palate, or both, in southern Sweden, 2006-2010.},
  url          = {http://dx.doi.org/10.3109/2000656X.2012.668773},
  volume       = {46},
  year         = {2012},
}