Advanced

Human immunodeficiency virus (HIV)-2-specific T lymphocyte proliferative responses in HIV-2-infected and in HIV-2-exposed but uninfected individuals in Guinea-Bissau

Andersson, S; Larsen, O; Da Silva, Z; Linder, H; Norrgren, Hans LU ; Dias, F; Thorstensson, R; Aaby, P and Biberfeld, G (2005) In Clinical and Experimental Immunology 139(3). p.483-489
Abstract
Human immunodeficiency virus (HIV)-2-specific T lymphocyte proliferative responses were determined in cultures of peripheral blood mononuclear cells from HIV-2-exposed uninfected individuals, HIV-2-infected individuals and HIV-negative controls in Guinea-Bissau. Increased HIV-2-specific T lymphocyte proliferative responses were detected in both groups compared to HIV-negative controls (healthy HIV-uninfected individuals without known exposure to an HIV-infected person); five out of 29 of the HIV-2-exposed uninfected and half (16 of 32) of the HIV-2-infected individuals had stimulation indexes >2, compared to one out of 49 of the HIV-negative controls (P = 0.003 and P < 0.0001, respectively). The exposed uninfected individuals had... (More)
Human immunodeficiency virus (HIV)-2-specific T lymphocyte proliferative responses were determined in cultures of peripheral blood mononuclear cells from HIV-2-exposed uninfected individuals, HIV-2-infected individuals and HIV-negative controls in Guinea-Bissau. Increased HIV-2-specific T lymphocyte proliferative responses were detected in both groups compared to HIV-negative controls (healthy HIV-uninfected individuals without known exposure to an HIV-infected person); five out of 29 of the HIV-2-exposed uninfected and half (16 of 32) of the HIV-2-infected individuals had stimulation indexes >2, compared to one out of 49 of the HIV-negative controls (P = 0.003 and P < 0.0001, respectively). The exposed uninfected individuals had reactivity to a HIV-2 V3-peptide corresponding to amino acids 311-326 of the envelope glycoprotein, while the HIV-2-infected people reacted mainly to HIV-2 whole viral lysate. Thus, this study demonstrates a high degree of HIV-2-specific T helper cell activity, as measured by lymphocyte proliferation, in HIV-2-exposed uninfected individuals as well as in HIV-2-infected subjects. These immune responses could be important for resistance to the infection and for the control of established infection and, thus, play a role in the lower transmission and progression of HIV-2 compared to HIV-1. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
lymphocyte proliferation, immunity, HIV-2, Africa, exposed-uninfected
in
Clinical and Experimental Immunology
volume
139
issue
3
pages
483 - 489
publisher
British Society for Immunology
external identifiers
  • pmid:15730394
  • wos:000227226900013
  • scopus:14744301692
ISSN
0009-9104
DOI
10.1111/j.1365-2249.2005.02723.x
language
English
LU publication?
yes
id
6fc3252a-77e3-42b5-a008-8aab97721899 (old id 252023)
date added to LUP
2007-08-14 11:21:52
date last changed
2017-01-01 04:56:16
@article{6fc3252a-77e3-42b5-a008-8aab97721899,
  abstract     = {Human immunodeficiency virus (HIV)-2-specific T lymphocyte proliferative responses were determined in cultures of peripheral blood mononuclear cells from HIV-2-exposed uninfected individuals, HIV-2-infected individuals and HIV-negative controls in Guinea-Bissau. Increased HIV-2-specific T lymphocyte proliferative responses were detected in both groups compared to HIV-negative controls (healthy HIV-uninfected individuals without known exposure to an HIV-infected person); five out of 29 of the HIV-2-exposed uninfected and half (16 of 32) of the HIV-2-infected individuals had stimulation indexes &gt;2, compared to one out of 49 of the HIV-negative controls (P = 0.003 and P &lt; 0.0001, respectively). The exposed uninfected individuals had reactivity to a HIV-2 V3-peptide corresponding to amino acids 311-326 of the envelope glycoprotein, while the HIV-2-infected people reacted mainly to HIV-2 whole viral lysate. Thus, this study demonstrates a high degree of HIV-2-specific T helper cell activity, as measured by lymphocyte proliferation, in HIV-2-exposed uninfected individuals as well as in HIV-2-infected subjects. These immune responses could be important for resistance to the infection and for the control of established infection and, thus, play a role in the lower transmission and progression of HIV-2 compared to HIV-1.},
  author       = {Andersson, S and Larsen, O and Da Silva, Z and Linder, H and Norrgren, Hans and Dias, F and Thorstensson, R and Aaby, P and Biberfeld, G},
  issn         = {0009-9104},
  keyword      = {lymphocyte proliferation,immunity,HIV-2,Africa,exposed-uninfected},
  language     = {eng},
  number       = {3},
  pages        = {483--489},
  publisher    = {British Society for Immunology},
  series       = {Clinical and Experimental Immunology},
  title        = {Human immunodeficiency virus (HIV)-2-specific T lymphocyte proliferative responses in HIV-2-infected and in HIV-2-exposed but uninfected individuals in Guinea-Bissau},
  url          = {http://dx.doi.org/10.1111/j.1365-2249.2005.02723.x},
  volume       = {139},
  year         = {2005},
}