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The genome of the sea urchin Strongylocentrotus purpuratus

Sodergren, Erica ; Weinstock, George M ; Davidson, Eric H ; Cameron, R Andrew ; Gibbs, Richard A ; Angerer, Robert C ; Angerer, Lynne M ; Arnone, Maria Ina ; Burgess, David R and Burke, Robert D , et al. (2006) In Science (New York, N.Y.) 314(5801). p.941-952
Abstract

We report the sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing strategy combined whole-genome shotgun and bacterial artificial chromosome (BAC) sequences. This use of BAC clones, aided by a pooling strategy, overcame difficulties associated with high heterozygosity of the genome. The genome encodes about 23,300 genes, including many previously thought to be vertebrate innovations or known only outside the deuterostomes. This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes.

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author collaboration
publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Calcification, Physiologic, Cell Adhesion Molecules/genetics, Complement Activation/genetics, Computational Biology, Embryonic Development/genetics, Evolution, Molecular, Gene Expression Regulation, Developmental, Genes, Genome, Immunity, Innate/genetics, Immunologic Factors/genetics, Male, Nervous System Physiological Phenomena, Proteins/genetics, Sequence Analysis, DNA, Signal Transduction, Strongylocentrotus purpuratus/embryology, Transcription Factors/genetics
in
Science (New York, N.Y.)
volume
314
issue
5801
pages
941 - 952
publisher
American Association for the Advancement of Science
external identifiers
  • scopus:33750995860
  • pmid:17095691
ISSN
1095-9203
DOI
10.1126/science.1133609
language
English
LU publication?
no
id
252776b0-42db-4717-ab3f-50eb0fe20e0b
date added to LUP
2019-11-10 16:55:14
date last changed
2020-09-23 07:59:10
@article{252776b0-42db-4717-ab3f-50eb0fe20e0b,
  abstract     = {<p>We report the sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing strategy combined whole-genome shotgun and bacterial artificial chromosome (BAC) sequences. This use of BAC clones, aided by a pooling strategy, overcame difficulties associated with high heterozygosity of the genome. The genome encodes about 23,300 genes, including many previously thought to be vertebrate innovations or known only outside the deuterostomes. This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes.</p>},
  author       = {Sodergren, Erica and Weinstock, George M and Davidson, Eric H and Cameron, R Andrew and Gibbs, Richard A and Angerer, Robert C and Angerer, Lynne M and Arnone, Maria Ina and Burgess, David R and Burke, Robert D and Coffman, James A and Dean, Michael and Elphick, Maurice R and Ettensohn, Charles A and Foltz, Kathy R and Hamdoun, Amro and Hynes, Richard O and Klein, William H and Marzluff, William and McClay, David R and Morris, Robert L and Mushegian, Arcady and Rast, Jonathan P and Smith, L Courtney and Thorndyke, Michael C and Vacquier, Victor D and Wessel, Gary M and Wray, Greg and Zhang, Lan and Elsik, Christine G and Ermolaeva, Olga and Hlavina, Wratko and Hofmann, Gretchen and Kitts, Paul and Landrum, Melissa J and Mackey, Aaron J and Maglott, Donna and Panopoulou, Georgia and Poustka, Albert J and Pruitt, Kim and Sapojnikov, Victor and Song, Xingzhi and Souvorov, Alexandre and Solovyev, Victor and Wei, Zheng and Whittaker, Charles A and Worley, Kim and Durbin, K James and Jackson, Andrew R and Elhaik, Eran and Wright, Rita},
  issn         = {1095-9203},
  language     = {eng},
  month        = {11},
  number       = {5801},
  pages        = {941--952},
  publisher    = {American Association for the Advancement of Science},
  series       = {Science (New York, N.Y.)},
  title        = {The genome of the sea urchin Strongylocentrotus purpuratus},
  url          = {http://dx.doi.org/10.1126/science.1133609},
  doi          = {10.1126/science.1133609},
  volume       = {314},
  year         = {2006},
}