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Induction of mammary fibroadenomas in rats by adenovirus type 9

Ankerst, J. LU orcid ; Jonsson, N. LU ; Kjellén, L. ; Norrby, E. and Sjögren, H. O. LU (1974) In International Journal of Cancer 13(3). p.286-290
Abstract

After inoculation of adenovirus type 9 into newborn Wistar/Furth rats, seven out of seven females developed one or several mammary fibroadenomas within 14–25 weeks after virus inoculation. No tumours were observed in male rats inoculated with the same virus or in untreated controls. Neonatal inoculations of adenovirus type 5, produced on the same HeLa cells, gave negative results in both sexes. The results indicate that benign mammary tumours can be induced in rats by a virus and that mammary fibroadenomas are induced by adenovirus type 9, previously known to be capable of transforming cells in vitro but not of inducing tumours in vivo.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Cancer
volume
13
issue
3
pages
5 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:4822103
  • scopus:0015994279
ISSN
0020-7136
DOI
10.1002/ijc.2910130303
language
English
LU publication?
yes
id
252dca26-88fc-4c49-81f0-546256d0380d
date added to LUP
2021-11-29 15:55:05
date last changed
2024-04-20 18:37:23
@article{252dca26-88fc-4c49-81f0-546256d0380d,
  abstract     = {{<p>After inoculation of adenovirus type 9 into newborn Wistar/Furth rats, seven out of seven females developed one or several mammary fibroadenomas within 14–25 weeks after virus inoculation. No tumours were observed in male rats inoculated with the same virus or in untreated controls. Neonatal inoculations of adenovirus type 5, produced on the same HeLa cells, gave negative results in both sexes. The results indicate that benign mammary tumours can be induced in rats by a virus and that mammary fibroadenomas are induced by adenovirus type 9, previously known to be capable of transforming cells in vitro but not of inducing tumours in vivo.</p>}},
  author       = {{Ankerst, J. and Jonsson, N. and Kjellén, L. and Norrby, E. and Sjögren, H. O.}},
  issn         = {{0020-7136}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{3}},
  pages        = {{286--290}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{International Journal of Cancer}},
  title        = {{Induction of mammary fibroadenomas in rats by adenovirus type 9}},
  url          = {{http://dx.doi.org/10.1002/ijc.2910130303}},
  doi          = {{10.1002/ijc.2910130303}},
  volume       = {{13}},
  year         = {{1974}},
}