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Recent investigations on calorimetric biosensors

Danielsson, B. LU ; Hedberg, U. ; Rank, M. and Xie, B. LU (1992) In Sensors and Actuators B: Chemical 6(1-3). p.138-142
Abstract

New applications of a flow-calorimetric biosensor system, the enzyme thermistor (ET) are described. The ET measures the reaction heat in a small column containing immobilized biocatalyst as a temperature change of the effluent from the column. Since most biological reactions are exothermic, the ET has a very broad applicability and numerous assays of clinical as well as biotechnological interest have been studied. The procedure is well suited for monitoring and control of biotechnological processes due to its high operational stability. New results from this area are presented as well as developments on an automated thermometric immunoassay (TELISA). Miniaturized ET devices are suitable for portable monitoring of, for instance, blood... (More)

New applications of a flow-calorimetric biosensor system, the enzyme thermistor (ET) are described. The ET measures the reaction heat in a small column containing immobilized biocatalyst as a temperature change of the effluent from the column. Since most biological reactions are exothermic, the ET has a very broad applicability and numerous assays of clinical as well as biotechnological interest have been studied. The procedure is well suited for monitoring and control of biotechnological processes due to its high operational stability. New results from this area are presented as well as developments on an automated thermometric immunoassay (TELISA). Miniaturized ET devices are suitable for portable monitoring of, for instance, blood glucose. Other recent work includes determinations in organic solvents, direct characterization of immobilized biocatalysts and monitoring of bioactivities in solution.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Sensors and Actuators B: Chemical
volume
6
issue
1-3
pages
5 pages
publisher
Elsevier
external identifiers
  • scopus:0026455368
ISSN
0925-4005
DOI
10.1016/0925-4005(92)80045-Y
language
English
LU publication?
yes
id
253db08e-5d0e-44ea-a2df-2f39d2b863ee
date added to LUP
2021-10-27 16:15:29
date last changed
2021-11-01 12:47:58
@article{253db08e-5d0e-44ea-a2df-2f39d2b863ee,
  abstract     = {{<p>New applications of a flow-calorimetric biosensor system, the enzyme thermistor (ET) are described. The ET measures the reaction heat in a small column containing immobilized biocatalyst as a temperature change of the effluent from the column. Since most biological reactions are exothermic, the ET has a very broad applicability and numerous assays of clinical as well as biotechnological interest have been studied. The procedure is well suited for monitoring and control of biotechnological processes due to its high operational stability. New results from this area are presented as well as developments on an automated thermometric immunoassay (TELISA). Miniaturized ET devices are suitable for portable monitoring of, for instance, blood glucose. Other recent work includes determinations in organic solvents, direct characterization of immobilized biocatalysts and monitoring of bioactivities in solution.</p>}},
  author       = {{Danielsson, B. and Hedberg, U. and Rank, M. and Xie, B.}},
  issn         = {{0925-4005}},
  language     = {{eng}},
  number       = {{1-3}},
  pages        = {{138--142}},
  publisher    = {{Elsevier}},
  series       = {{Sensors and Actuators B: Chemical}},
  title        = {{Recent investigations on calorimetric biosensors}},
  url          = {{http://dx.doi.org/10.1016/0925-4005(92)80045-Y}},
  doi          = {{10.1016/0925-4005(92)80045-Y}},
  volume       = {{6}},
  year         = {{1992}},
}