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Less local pain on intravenous infusion of a new propofol emulsion

Liljeroth, Elisabeth LU and Åkeson, Jonas LU (2005) In Acta Anaesthesiologica Scandinavica 49(2). p.248-251
Abstract
Background: Local pain at the site of intravenous (iv) injection of propofol remains a considerable problem in clinical anaesthesiology, and particularly so in infants. The aim of the present study was to compare the influence of two different emulsions of propofol on local pain following iv administration. Methods: Eighty adult patients (ASA I-II) scheduled for ear-nose-throat or plastic surgery were randomly allocated into two study groups: A and B. A 1.0-mm teflon cannula (BD, Helsingborg, Sweden) was inserted into a dorsal vein on each hand. Each patient was given two 3.0-ml iv bolus injections of two different propofol emulsions of 10 mg ml(-1) over 2 s, one in each cannula, at 5-min intervals. The first study drug administered was... (More)
Background: Local pain at the site of intravenous (iv) injection of propofol remains a considerable problem in clinical anaesthesiology, and particularly so in infants. The aim of the present study was to compare the influence of two different emulsions of propofol on local pain following iv administration. Methods: Eighty adult patients (ASA I-II) scheduled for ear-nose-throat or plastic surgery were randomly allocated into two study groups: A and B. A 1.0-mm teflon cannula (BD, Helsingborg, Sweden) was inserted into a dorsal vein on each hand. Each patient was given two 3.0-ml iv bolus injections of two different propofol emulsions of 10 mg ml(-1) over 2 s, one in each cannula, at 5-min intervals. The first study drug administered was Diprivan((R)) (AstraZeneca, Sodertalie, Sweden) in group A (n = 34) and Propofol-Lipuro (Braun, Melsungen, Germany) in group B (n = 39). Each patient was then asked by a blinded investigator to score maximal pain intensity on a visual analogue scale (VAS). Results: The maximal intensity of propofol-induced local pain was significantly (P < 0.0001) lower after Propofol-Lipuro than after Diprivan((R))- median 1 (25th percentile: 0; 75th percentile: 2) range 0-6 vs. 3 (0; 5) 0-9 VAS units. Conclusion: The considerably lower intensity of local pain found to be associated with iv administration of the new drug formula Propofol-Lipuro indicates that emulsions of propofol based on medium- and long-chain triglycerides have a clinical advantage over traditional ones for induction of anaesthesia. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
intravenous, injection, emulsion, anesthesia, formula, pain, propofol, visual analogue scale
in
Acta Anaesthesiologica Scandinavica
volume
49
issue
2
pages
248 - 251
publisher
Wiley-Blackwell
external identifiers
  • pmid:15715629
  • wos:000227062200020
  • scopus:14644425272
ISSN
0001-5172
DOI
10.1111/j.1399-6576.2004.00573.x
language
English
LU publication?
yes
id
407f5125-0995-4eec-bcaa-c9fcdf17ad78 (old id 254012)
date added to LUP
2007-08-16 14:19:39
date last changed
2017-04-09 03:36:59
@article{407f5125-0995-4eec-bcaa-c9fcdf17ad78,
  abstract     = {Background: Local pain at the site of intravenous (iv) injection of propofol remains a considerable problem in clinical anaesthesiology, and particularly so in infants. The aim of the present study was to compare the influence of two different emulsions of propofol on local pain following iv administration. Methods: Eighty adult patients (ASA I-II) scheduled for ear-nose-throat or plastic surgery were randomly allocated into two study groups: A and B. A 1.0-mm teflon cannula (BD, Helsingborg, Sweden) was inserted into a dorsal vein on each hand. Each patient was given two 3.0-ml iv bolus injections of two different propofol emulsions of 10 mg ml(-1) over 2 s, one in each cannula, at 5-min intervals. The first study drug administered was Diprivan((R)) (AstraZeneca, Sodertalie, Sweden) in group A (n = 34) and Propofol-Lipuro (Braun, Melsungen, Germany) in group B (n = 39). Each patient was then asked by a blinded investigator to score maximal pain intensity on a visual analogue scale (VAS). Results: The maximal intensity of propofol-induced local pain was significantly (P &lt; 0.0001) lower after Propofol-Lipuro than after Diprivan((R))- median 1 (25th percentile: 0; 75th percentile: 2) range 0-6 vs. 3 (0; 5) 0-9 VAS units. Conclusion: The considerably lower intensity of local pain found to be associated with iv administration of the new drug formula Propofol-Lipuro indicates that emulsions of propofol based on medium- and long-chain triglycerides have a clinical advantage over traditional ones for induction of anaesthesia.},
  author       = {Liljeroth, Elisabeth and Åkeson, Jonas},
  issn         = {0001-5172},
  keyword      = {intravenous,injection,emulsion,anesthesia,formula,pain,propofol,visual analogue scale},
  language     = {eng},
  number       = {2},
  pages        = {248--251},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Anaesthesiologica Scandinavica},
  title        = {Less local pain on intravenous infusion of a new propofol emulsion},
  url          = {http://dx.doi.org/10.1111/j.1399-6576.2004.00573.x},
  volume       = {49},
  year         = {2005},
}