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Molecular control of follicular helper T cell development and differentiation

Wu, Haijing ; Deng, Yaxiong LU ; Zhao, Ming ; Zhang, Jianzhong ; Zheng, Min ; Chen, Genghui ; Li, Linfeng ; He, Zhibiao and Lu, Qianjin (2018) In Frontiers in Immunology 9(OCT).
Abstract

Follicular helper T cells (Tfh) are specialized helper T cells that are predominantly located in germinal centers and provide help to B cells. The development and differentiation of Tfh cells has been shown to be regulated by transcription factors, such as B-cell lymphoma 6 protein (Bcl-6), signal transducer and activator of transcription 3 (STAT3) and B lymphocyte-induced maturation protein-1 (Blimp-1). In addition, cytokines, including IL-21, have been found to be important for Tfh cell development. Moreover, several epigenetic modifications have also been reported to be involved in the determination of Tfh cell fate. The regulatory network is complicated, and the number of novel molecules demonstrated to control the fate of Tfh cells... (More)

Follicular helper T cells (Tfh) are specialized helper T cells that are predominantly located in germinal centers and provide help to B cells. The development and differentiation of Tfh cells has been shown to be regulated by transcription factors, such as B-cell lymphoma 6 protein (Bcl-6), signal transducer and activator of transcription 3 (STAT3) and B lymphocyte-induced maturation protein-1 (Blimp-1). In addition, cytokines, including IL-21, have been found to be important for Tfh cell development. Moreover, several epigenetic modifications have also been reported to be involved in the determination of Tfh cell fate. The regulatory network is complicated, and the number of novel molecules demonstrated to control the fate of Tfh cells is increasing. Therefore, this review aims to summarize the current knowledge regarding the molecular regulation of Tfh cell development and differentiation at the protein level and at the epigenetic level to elucidate Tfh cell biology and provide potential targets for clinical interventions in the future.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bcl-6, Blimp-1, Epigenetics, Tfh, Transcription factors
in
Frontiers in Immunology
volume
9
issue
OCT
article number
02470
publisher
Frontiers Media S. A.
external identifiers
  • scopus:85055819219
  • pmid:30410493
ISSN
1664-3224
DOI
10.3389/fimmu.2018.02470
language
English
LU publication?
yes
id
25409f3f-712e-4533-b2ac-95035dd1b0f7
date added to LUP
2018-11-15 11:12:48
date last changed
2021-10-06 05:46:47
@article{25409f3f-712e-4533-b2ac-95035dd1b0f7,
  abstract     = {<p>Follicular helper T cells (Tfh) are specialized helper T cells that are predominantly located in germinal centers and provide help to B cells. The development and differentiation of Tfh cells has been shown to be regulated by transcription factors, such as B-cell lymphoma 6 protein (Bcl-6), signal transducer and activator of transcription 3 (STAT3) and B lymphocyte-induced maturation protein-1 (Blimp-1). In addition, cytokines, including IL-21, have been found to be important for Tfh cell development. Moreover, several epigenetic modifications have also been reported to be involved in the determination of Tfh cell fate. The regulatory network is complicated, and the number of novel molecules demonstrated to control the fate of Tfh cells is increasing. Therefore, this review aims to summarize the current knowledge regarding the molecular regulation of Tfh cell development and differentiation at the protein level and at the epigenetic level to elucidate Tfh cell biology and provide potential targets for clinical interventions in the future.</p>},
  author       = {Wu, Haijing and Deng, Yaxiong and Zhao, Ming and Zhang, Jianzhong and Zheng, Min and Chen, Genghui and Li, Linfeng and He, Zhibiao and Lu, Qianjin},
  issn         = {1664-3224},
  language     = {eng},
  month        = {10},
  number       = {OCT},
  publisher    = {Frontiers Media S. A.},
  series       = {Frontiers in Immunology},
  title        = {Molecular control of follicular helper T cell development and differentiation},
  url          = {http://dx.doi.org/10.3389/fimmu.2018.02470},
  doi          = {10.3389/fimmu.2018.02470},
  volume       = {9},
  year         = {2018},
}